Neither is being left-handed, but we manage to accept that "not the most normal" does not mean "bad".
I understand that something this unusual does seem difficult to accept, but it's important to remember that these people are making unusual biological choices
because they are faced with unusual biological circumstances.
I'm really not trying to pick on you here. It's perfectly ok to be uncomfortable with what they are going through. It's probably not something you have any experience with. Unusual stuff can be difficult for all of us.
Just try to remember that it's
more difficult
for the people who have to deal with unusual circumstances. If you never get over feeling weird about it, that's ok. Just don't burden them with that problem, too.