Myofascial Pain and Treatment
Osteopathic manipulative treatment combined with exercise improves pain and disability in individuals with non-specific chronic neck pain: A pragmatic randomized controlled trial

https://doi.org/10.1016/j.jbmt.2019.11.002Get rights and content

Highlights

  • The combination of osteopathic manipulative treatment and exercise is effective for patients with chronic neck pain.
  • The results support this treatment combination for pain reduction and improved function.
  • Exercise and OMT has also been shown to be helpful in the management of neck pain.

Abstract

Purpose

To determine effectiveness of osteopathic manipulative treatment combined with stretching and strengthening exercises in the cervical region on pain and disability in individuals with non-specific chronic neck pain.

Methods

90 adults with non-specific chronic neck pain were randomized to either exercises group (EG, n = 45) or osteopathic manipulative treatment associated with exercises group (OMT/EG, n = 45). The primary outcomes were obtained by the use of Numeric Pain-Rating Scale (NPRS), Pressure Pain Threshold (PPT) and Neck Disability Index (NDI). Secondary outcomes included range of motion (ROM) for cervical spine rotation, Fear-Avoidance Beliefs Questionnaire Work/Physical Activity (FABQ-W/PA) and Pain-self efficacy at two different moments: baseline and 4 weeks after the first treatment. Techniques and dosages of OMT were selected pragmatically by a registered osteopath. Generalized Estimating Equations model (GEE), complemented by the Least Significant Difference (LSD) and the intention-to-treat analysis, was used to assess the clinical outcomes.

Results

Analysis with GEE indicated that OMT/EG reduced pain and disability more than the EG alone after 4 weeks of treatment with statistically significant difference (p < 0,05), as well as cervical active rotation was significantly improved (p = 0.03). There were no between-group differences observed in Pressure Pain Threshold (PPT) measure, Fear-Avoidance Beliefs Questionnaire and Pain-self efficacy.

Conclusion

The association between OMT and exercises reduces pain and improves functional disability more than only exercise for individuals with non-specific chronic neck pain.

Introduction

Neck pain is a common condition with a reported prevalence ranging from 22% to 70% among the general population, and it is more common in women than in men (Blanpied et al., 2017). Neck pain, as well as low back pain, is the leading cause of disability measured in years lived with disability (L. Carroll, 2000; Hogg-Johnson et al., 2008; Palmer et al., 2001; Vos et al., 2016). Studies show that up to 54% of people will suffer from cervical pain at some point in their lives, and almost all of them will still have symptoms during the first five years after the first episode of pain (L. J. Carroll et al., 2009; Côté et al., 2004; Wright et al., 1999). Consequently, neck pain results in major health costs, mainly due to absenteeism from work (Blanpied et al., 2017; Bronfort et al., 2001).
Since the cause of pain is unknown in most cases, neck pain is labeled as non-specific chronic neck pain (NCNP) (Hidalgo et al., 2017). However, several factors may contribute to NCNP, such as mechanical and biological aspects (age, gender, history of trauma and musculoskeletal diseases), and other factors related to psychosocial characteristics (physical activity, beliefs, expectations and job satisfaction). These factors are known as having an influence on the transition from acute to chronic pain (Bronfort et al., 2001; Curatolo et al., 2011; Hidalgo et al., 2017).
There are several NCNP management options, including manual therapy, conventional physiotherapy, drug treatment, exercise, pain education, among others (Borghouts et al., 1999; Cleland et al., 2005; Gross et al., 2015; Lau et al., 2011). Manual therapy is a widely used approach, and there has been a significant increase in the number of clinical trials investigating this practice in recent years (Cross et al., 2011; Miller et al., 2010; Vincent et al., 2013). Although there is moderate evidence to support the use of manipulative treatments for cervical pain, the literature shows it is more effective than no intervention or placebo treatment (González-Iglesias et al., 2009; Gross et al., 2010; Schwerla et al., 2008).
A combination of several treatment modalities is referred as multimodal care. Combined manual therapy and exercises have also led to the improvement of patient outcomes when compared to manual therapy or exercises alone (Walker et al., 2008).
Osteopathic manipulative treatment (OMT) is a noninvasive approach that incorporates manual diagnostic and treatment techniques in accordance to pre-established principles, such as interrelation between structure and function, intrinsic self-regulation and homeostasis, and concept of body unity (Kuchera, 2007).
Current evidence indicates that OMT is more effective than placebo treatment or no treatment for pain and function (Franke et al., 2015; Hamilton et al., 2007; Mandara et al., 2010). A recent systematic review (Franke et al., 2015) demonstrated clinically relevant effects of OMT for reducing pain in patients with NCNP. However, these studies have not investigated the effectiveness and impact of OMT combined with exercises on NCNP patients.
Therefore, the objective of this clinical trial was to assess the effectiveness of osteopathic manipulative treatment combined with stretching and strengthening exercises on the cervical region for conservative treatment of individuals with NCNP.

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Section snippets

Study design

This study was a pragmatic single-blinded randomized controlled trial conducted from June 2017 to December 2018. Pragmatic studies are designed to evaluate the effectiveness of interventions in real-life practice conditions and to test interventions in the full spectrum of everyday clinical settings in order to maximize clinical applicability (Harper et al., 2019; Patsopoulos, 2011; Treweek and Zwarenstein, 2009).
The study protocol was approved by the local human research ethics committee and

Results

In total, 90 individuals were assessed for eligibility criteria, from June 2017 to December 2018, and then randomly assigned to the exercise (n = 45) and OMT/EG (n = 45) groups (Fig. 1). The subjects of the both groups showed similar baseline characteristics. There were no statistically significant differences between-groups at baseline characteristics (gender, age, weight, height and body mass index, NPRS, NDI, FABQ, HADS) (p > 0.05; Table 1). No adverse events were reported during study.
There

Discussion

The main purpose of the present study was to assess the combination of OMT and strengthening and stretching exercises in subjects with non-specific chronic neck pain and disability. The results demonstrated that combining both treatments led to reduction of pain and improvements of function disability. Multiple factors may have contributed to the improvement in the functioning and pain levels in individuals with chronic neck pain after osteopathic manipulative treatment in combination with

Conclusion

The results of this randomized controlled trial demonstrated that combining Osteopathic Manipulative Treatment with exercise is better than exercise alone for pain, disability and rotational mobility of the neck. The findings also provide some evidence that individuals with no specific chronic neck pain can be treated with osteopathic manipulative treatment along with exercises.

Clinical relevance

Osteopathic manipulative treatment combined with exercise applied 4 times led to clinically relevant positive changes in pain intensity and functional disability in individuals with chronic non-specific neck pain. In a short-term, it is a safe and an additional option of treatment.

Financial disclosure

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) – Finance Code 001. The funding agency was not involved in the study design, in the collection, analysis and interpretation of the data or in drafting manuscript.

Declaration of competing interest

None.

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