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In the Realms, magically resistant bacteria are only going to come into being in a living organism that tarries (or is caught) inside a magically-strong area (e.g. within a mythal), or feels the effects of a powerful (7th level or higher) spell.
So they will...
#realmslore
Rx What about magically resistant bacteria?
0.000001% magic resistance might require 5 cure diseases instead of one, for example....
Dec 19, 2025 · 5:17 AM UTC
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...exist, but be rare. A cure disease will always initially work on them 100% (that is, removing all effects/making the disease latent so it seems to have “ended,” but then will come back, far more mildly, later (how long, up to the DM; how severe, depends on...
#realmslore
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...all sorts of factors, including overall health of the afflicted…but as a DM, I would never rule on anything needing more than three cure diseases: the third casting should end a disease for good.
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