Usually not. She will usually have just one human child, though it may have unusually good eyesight or the ability to smell, akin to a wolf. If there were going to be multiple wolves of both genders in her litter, this may result in her having human twins.
#realmslore
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Ye Olde Basilisk
@olde_basilisk
Replying to @RenMasaoAnkoku and @TheEdVerse
Follow-up follow-up question: if the mother Druid is impregnated by a wolf and then she shifts into human form to deliver, does she have a whole litter of humans?