Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as to allow video information to be shared for both marketing, analytics and editorial purposes.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.

Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Preclinical research: Make mouse studies work

More investment to characterize animal models can boost the ability of preclinical work to predict drug effects in humans, says Steve Perrin.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

¥ 4,980

Prices may be subject to local taxes which are calculated during checkout

References

  1. Scott, S. et al. Amyotroph. Lateral Scler. 9, 4–15 (2008).

    Article  CAS  Google Scholar 

  2. Begley, C. G. & Ellis, L. M. Nature 483, 531–533 (2012).

    Article  ADS  CAS  Google Scholar 

  3. Ling, S.-C., Polymenidou, M. & Cleveland, D. W. Neuron 79, 416–438 (2013).

    Article  CAS  Google Scholar 

  4. Wegorzewska, I., Bell, S., Cairns, N. J., Miller, T. M. & Baloh, R. H. Proc. Natl Acad. Sci. USA 106, 18809–18814 (2009).

    Article  ADS  CAS  Google Scholar 

  5. Hatzipetros, T. et al. Brain Res. http://dx.doi.org/10.1016/j.brainres.2013.10.013 (2013).

  6. Ludolph, A. C. et al. Amyotroph. Lateral Scler. 11, 38–45 (2010).

    Article  Google Scholar 

  7. Stallings, N. R., Puttaparthi, K., Luther, C. M., Burns, D. K. & Elliott, J. L. Neurobiol. Dis. 40, 404–414 (2010).

    Article  CAS  Google Scholar 

  8. Fornai, F. et al. Proc. Natl Acad. Sci. USA 105, 2052–2057 (2008).

    Article  ADS  CAS  Google Scholar 

  9. UKMND-LiCALS Study Group Lancet Neurol. 12, 339–345 (2013).

  10. Verstraete, E. et al. J. Neurol. Neurosurg. Psychiatr. 83, 557–564 (2012).

    Article  Google Scholar 

  11. Aggarwal, S. P. et al. Lancet Neurol. 9, 481–488 (2010).

    Article  CAS  Google Scholar 

  12. Gill, A., Kidd, J., Vieira, F., Thompson, K. & Perrin, S. PLoS ONE 4, e6489 (2009).

    Article  ADS  Google Scholar 

  13. Pizzasegola, C. et al. Amyotroph. Lateral Scler. 10, 221–228 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Steve Perrin.

Supplementary information

Related links

Related links

Related links in Nature Research

Model organisms: There's more to life than rats and flies 2012-Oct-31

Drug development: Raise standards for preclinical cancer research 2012-Mar-28

Why animal research needs to improve 2011-Sep-28

Animal studies paint misleading picture 2010-Mar-30

Related external links

ALS Therapy Development Institute

Rights and permissions

Reprints and permissions

About this article

Cite this article

Perrin, S. Preclinical research: Make mouse studies work. Nature 507, 423–425 (2014). https://doi.org/10.1038/507423a

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/507423a

This article is cited by

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research