Federal Agents Shoot 2 During Traffic Stop in Portland, Ore.

Federal agents shot two people in Portland on Thursday during a traffic stop, a day after the fatal shooting of a woman in Minneapolis stoked outrage over the Trump administration’s immigration crackdown.

A Homeland Security Department spokeswoman said in a statement that U.S. Border Patrol agents were conducting a “targeted vehicle stop,” and that an agent fired a shot after the driver tried to run them over.

The spokeswoman, Tricia McLaughlin, described the agents’ target as an undocumented immigrant and member of Tren de Aragua, a gang with roots in a Venezuelan prison that has been a frequent target of President Trump. She provided no immediate evidence that the person who was targeted was affiliated with the gang.

Bob Day, Portland’s police chief, said at an evening news conference that he had no information on the identity of the two people who were shot, a man and a woman. He said that the federal officials involved in the shooting were no longer on the scene when local officers arrived.

The police were alerted to the shooting when the injured man called 911, Chief Day said.

The chief’s comments appeared to underscore the limited cooperation between federal and local officials. Chief Day said local officials knew little about the shooting and that the investigation would be led by the F.B.I. “We do not know if this is an immigration-related event,” he said. “We do not know which federal agencies were involved.”

Gov. Tina Kotek of Oregon called for a full and transparent federal investigation. “Trust is essential to maintain community safety and uphold the law,” she said. “Federal agents at the direction of the Department of Homeland Security are shattering trust. They are destroying day by day what we hold dear.”

The shooting occurred around 2:15 p.m. Pacific near Adventist Health Portland, a hospital and collection of health clinics in the Hazelwood neighborhood, about eight miles from the city center, officials said.

The driver of the vehicle that federal officials fired into drove off after the shooting, local officials said, and the victims were found by the police more than two miles away, with gunshot wounds. Emergency medical technicians who rushed the victims to hospitals described both as Spanish speakers in conversations captured by emergency radio broadcasts. The woman had a gunshot wound to the chest, an E.M.T. told a dispatcher. The man was described as having two gunshot wounds.

Elana Pirtle-Guiney, Portland’s City Council president, said during a council meeting Thursday afternoon that she believed the two people who had been shot were still alive, though local officials later said they did not know their condition.

Teddy Jay, 20, a resident of the Bria apartment complex in Hazelwood, said he believed the two people who were shot lived in the complex but that he did not know their names. He said he saw them arrive by truck earlier in the afternoon.

“Basically, I was sitting in the house. I heard complete chaos. A whole lot of police sirens,” he said.

Mr. Jay said there was a bloody footprint on the sidewalk outside his building. He said he later saw an official providing medical aid and loading the two people into an ambulance.

Residents said the neighborhood has a high crime rate. A former resident at the complex, Debbie Rembert, 60, said the area “was so horrible — the shootings and the robberies and the drugs.”

Portland was the site of months of clashes between demonstrators and law enforcement after the murder of George Floyd by Minneapolis police officers in 2020. Last summer, protests at the city’s ICE facility at times turned violent, and led Mr. Trump to attempt to use the National Guard to quell demonstrations. A federal judge blocked that effort.

At the news conference Thursday, several officials sharply criticized the presence of federal officials in the city and demanded that they leave.

Kayse Jama, the majority leader of the Oregon State Senate, said that the shooting occurred near his home and that he was “outraged.” Addressing federal immigration officials directly, he said: “We do not need you. You are not welcome. You need to get the hell out of our community.”

On Thursday evening, hundreds gathered at an Immigration and Customs Enforcement building in Portland to protest the crackdown, chanting slogans including “no justice, no peace.”

Just before 9 p.m. local time, the police arrived and began moving protesters out of the area. The Portland Police Bureau said that its officers arrested six people there on charges of disorderly conduct.

Despite their criticism of the Trump administration’s immigration crackdown, local leaders urged calm, particularly in the wake of the already charged national environment following the fatal shooting of a woman by an Immigration and Customs Enforcement officer in Minneapolis on Wednesday.

Mayor Keith Wilson said the incident was another sign that federal immigration efforts were out of control. He called on the Trump administration to end enforcement operations in Portland.

“The administration is trying to divide us, to pit communities against one another, to make us fear one another,” he said. “Portland, this is a moment to hold each other close.”

Pooja Salhotra, Amanda Waldroupe and Aaron West contributed reporting. Susan C. Beachy contributed research.