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🎤 Snežana Đorđević recently shared insights on “A Multimodal Analytical Platform for Characterization of Crosslinked Polypeptide-based Nanoconjugates,” at #EPF2025! This talk highlighted the use of the mixed-bed TSKgel GMPWxl column for size screening of drug delivery systems—helping identify the most suitable single-pore SEC column for separating polypeptide-based nanoconjugates. Moreover, we demonstrated the need for a sensitive MALS detector, like our LenS3 MALS, coupled with SEC, for accurate molecular weight and size determination of these nanoconjugates. Overall, adequate physico-chemical characterization of drug delivery systems is crucial. Size and molecular weight are key parameters that influence their resistance to elimination by the hepatic, reticuloendothelial, or renal systems, and therefore modulate blood circulation times. #ChromatographyExperts #EuropeanPolymerCongress2025 #SEC #MALS

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Advance your discovery with Enamine’s Molecular Glue Libraries! Protein degradation and induced proximity are among the most rapidly evolving fields in modern drug discovery, set to bring several promising drugs to the market. After the surge of curiosity around PROTAC molecules, the smaller and easier-to-optimize Molecular Glues have emerged as the most promising drug modalities. Enamine supports your efforts to drug the undruggable — with the largest commercially available molecular glue libraries. We offer 4,900 compounds in the IMiD Library, 4,560 in the CRBN Molecular Glues Library, and 5,440 in the DCAF Library — all pre-plated and conveniently supplied as DMSO solutions, ready for screening. Discover more details: https://lnkd.in/gvsQWseA #DrugDiscovery #MolecularGlues #ProteinDegradation #Enamine

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Advancing extracellular vesicle-based precision medicine for cancer: in this review article, Hema Saranya Ilamathi, Gina Rinaldo and Oscar Wiklander at Karolinska Institutet examined cancer microenvironment-associated antigens that had been evaluated in both preclinical and clinical trials. In recent years, cancer precision medicine sparked significant research interest, particularly in emerging therapeutic strategies involving extracellular vesicles (EVs). As naturally occurring nanoparticles, EVs play a crucial role in intercellular communication and have shown considerable potential as targeted drug delivery vehicles due to their molecular transport capacity and inherent targeting capabilities 🔗 https://lnkd.in/eCfQ29Mx Targeted oncotherapy seeks to precisely eliminate cancer cells while minimizing off-target effects common in conventional treatments. However, the highly dynamic nature of cancer cells has limited the long-term efficacy of therapies based solely on tumor-associated antigens. Recognizing the critical role of the tumor microenvironment in cancer progression, the authors emphasized it as an additional therapeutic target. They further discussed how EVs could be engineered to recognize and target both cancer cell antigens and microenvironmental factors, offering a multi-pronged approach to cancer therapy. #extracellularvesicles #exosomes #cancer #tumourmicroenvironment #Vesiculab

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From routine PCR to high-fidelity NGS library prep, the right DNA polymerase can make all the difference. That’s why Watchmaker has built a comprehensive portfolio – so no matter your workflow, there’s a polymerase engineered to meet your needs. ✔ Robust PCR/qPCR solutions with high inhibitor tolerance and speed ✔ Isothermal amplification enzymes with custom QC to ensure reproducible field use ✔ High-fidelity library amplification solutions for NGS, including FFPE and cfDNA samples ✔ Specialized enzymes for applications like RCA, WGA, blunting, and nick translation Whether you’re building diagnostics, advancing research, or scaling sequencing studies, Watchmaker DNA polymerases provide performance and reliability. 👉 Explore the full portfolio (link in comments) #DNApolymerase #PCR #NGS #MolecularDiagnostics

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