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Coronavirus

Patent
US-10130701-B2
Inventor

BICKERTON ERICA (GB)

KEEP SARAH (GB)

BRITTON PAUL (GB)

Assignee
THE PIRBRIGHT INST (GB)
Country
United States
Dates
  • Priority:
    2014/07/23
  • Grant:
    2018/11/20
Description
This web page summarizes information in PubChem about patent US-10130701-B2. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed, please visit the PubChem patents help page.

1 Abstract

The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject.

2 Full Text

USPTO
Google

3 Important Dates

3.1 Priority Date

2014/07/23

3.2 Filing Date

2015/07/23

3.3 Publication Date

2018/11/20

3.4 Grant Date

2018/11/20

4 Inventor

BICKERTON ERICA (GB)

KEEP SARAH (GB)

BRITTON PAUL (GB)

5 Assignee

THE PIRBRIGHT INST (GB)

6 Country

United States

7 Linked Chemicals

7.1 PubChem Compounds

7.2 PubChem Substances

3 items

8 Linked Proteins

681 items
PubChem Protein
A2PYH4
Protein Name
Probable ATP-dependent DNA helicase HFM1 (human)
PubChem Protein
NP_002810
Protein Name
polypyrimidine tract-binding protein 1 isoform a (human)
PubChem Protein
P21128
Protein Name
Uridylate-specific endoribonuclease (human)
PubChem Protein
P26599
Protein Name
Polypyrimidine tract-binding protein 1 (human)
PubChem Protein
Q15517
Protein Name
Corneodesmosin (human)
Page of 137

9 Linked Genes

22 items
PubChem Gene
1041
Gene Name
CDSN - corneodesmosin (human)
PubChem Gene
8909
Gene Name
ENDOU - endonuclease, poly(U) specific (human)
PubChem Gene
25939
Gene Name
SAMHD1 - SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (human)
PubChem Gene
84284
Gene Name
NTPCR - nucleoside-triphosphatase, cancer-related (human)
PubChem Gene
19011
Gene Name
Endou - endonuclease, polyU-specific (house mouse)
Page of 5

10 Linked Taxonomies

8 items
Taxonomy ID
10245
Taxonomy
Vaccinia virus
Taxonomy ID
10261
Taxonomy
Fowlpox virus
Taxonomy ID
11137
Taxonomy
Human coronavirus 229E
Taxonomy ID
28295
Taxonomy
Porcine epidemic diarrhea virus
Taxonomy ID
277944
Taxonomy
Human coronavirus NL63
Page of 2

11 Patent Family

12 Classification

12.1 IPC

A61K39/00

C12N7/00 (inventive)

A61K39/215 (inventive, first)

C12N9/12 (inventive)

12.2 CPC

A61P31/14 (inventive)

C07K14/005 (inventive, first)

C12N2770/20071

A61K2039/70

C12N2770/20021

C12Y207/07048 (inventive)

C12N7/00 (inventive)

C12N2770/20022

A61K2039/5254

A61K39/215 (inventive, first)

C12N9/127 (inventive)

C12N2770/20062

C12N2770/20051

C12N2770/20034

A61K2039/54

13 Citations

  • WO-2004092360-A2 (APP)
  • WO-2005049814-A2 (APP)
  • WO-2007078203-A1 (APP)
  • US-7452542-B2 (SEA)
  • WO-2011004146-A1 (APP)
  • Altschul et al., Basic local alignment search tool. J. Mol. Biol. 215: 403-10 (1990). (APP,APP)
  • Ammayapppan et al., Identification of sequence changes responsible for the attenuation of avian infectious bronchitis virus strain Arkansas DPI, Arch. Virol., 154(3):495-9 (2009). (APP,APP)
  • Anonymous: "EM_STD:KF377577", Oct. 30, 2013. (APP)
  • Armesto et al., A recombinant avian infectious bronchitis virus expressing a heterologous spike gene belonging to the 4/91 serotype, PLoS One, 6(8):e24352 (2011). (APP,APP)
  • Armesto et al., The replicase gene of avian coronavirus infectious bronchitis virus is a determinant of pathogenicity, PLoS One, 4(10):e7384 (2009). (APP,APP)
  • Armesto et al., Transient dominant selection for the modification and generation of recombinant infectious bronchitis coronaviruses, Methods Mol. Biol., 454:255-73 (2008). (APP,APP)
  • Ausubel et al., Short Protocols in Molecular Biology, 4th edition, Chapter 18 (1999). (APP,APP)
  • Britton et al., Generation of a recombinant avian coronavirus infectious bronchitis virus using transient dominant selection, J. Virol. Methods, 123(2):203-11 (2005). (APP,APP)
  • Britton et al., Modification of the avian coronavirus infectious bronchitis virus for vaccine development, Bioeng. Bugs., 3(2):114-9 (2012). (APP,APP)
  • Casais et al., Recombinant avian infectious bronchitis virus expressing a heterologous spike gene demonstrates that the spike protein is a determinant of cell tropism, J. Virol., 77(16):9084-9 (2003). (APP,APP)
  • Casais et al., Reverse genetics system for the avian coronavirus infectious bronchitis virus, J. Virol., 75(24):12359-69 (2001). (APP,APP)
  • Cavanagh et al., Manipulation of the infectious bronchitis coronavirus genome for vaccine development and analysis of the accessory proteins, Vaccine, 25(30):5558-62 (2007). (APP,APP)
  • Devereux et al., A comprehensive set of sequence analysis programms for the VAX. Nucl. Acids Res.12: 387-95 (1984). (APP,APP)
  • International Preliminary Report on Patentability, International Application No. PCT/GB2015/052124, dated Jan. 24, 2017. (APP,APP)
  • International Search Report and Written Opinion, International Application No. PCT/GB2015/052124, dated Oct. 9, 2015. (APP,APP)
  • Larkin et al., Clustal W and Clustal X version 2.0, Bioinformatics, 23(21):2947-8 (2007). (APP,APP)
  • Menachery et al., Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2′-o-methyltransferase activity, J. Virol., 88(8):4251-64 (2014). (APP,APP)
  • Sperry Journal of Virology, 2005, vol. 79, No. 6, pp. 3391-3400. (SEA,SEA)
  • Tatusova et al., BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences, FEMS Microbiol. Lett., 174(2):247-50 (1999). (APP,APP)
  • Wang et al., Attenuation of porcine reproductive and respiratory syndrome virus strain MN184 using chimeric construction with vaccine sequence, Virology, 371(2):418-29 (2008). (APP,APP)
  • Wei et al., Development and characterization of a recombinant infectious bronchitis virus expressing the ectodomain region of S1 gene of H120 strain, Appl. Microbiol. Biotechnol., 98(4):1727-35 (2014). (APP,APP)

14 Cited By

15 Similar Patents

16 Information Sources

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