Enhanced Alginate Microparticles Fabricated by a Microfluidic System for Local Mesalamine Delivery to Inflammatory Bowel DiseaseClick to copy article linkArticle link copied!
- Shima OstovarShima OstovarBiotechnology Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran 14147613131, IranMore by Shima Ostovar
- Mohammad Amin ZakerMohammad Amin ZakerMicroproteomics Research Laboratory, School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran 1439957131, IranMore by Mohammad Amin Zaker
- Mohammad AkramiMohammad AkramiSchool of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, IranMore by Mohammad Akrami
- Amirhossein HeidariAmirhossein HeidariResearch Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran 1411718541, IranFaculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran 1941933111, IranMore by Amirhossein Heidari
- Yekta GhaneYekta GhaneResearch Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran 1411718541, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, IranMore by Yekta Ghane
- Nazila HeidariNazila HeidariResearch Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran 1411718541, IranSchool of Medicine, Iran University of Medical Sciences, Tehran 1449614535, IranMore by Nazila Heidari
- Homayoun Pishraft-SabetHomayoun Pishraft-SabetResearch Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran 1411718541, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, IranMore by Homayoun Pishraft-Sabet
- Parastou GorovanchiParastou GorovanchiDepartment of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz 5165665931, IranMore by Parastou Gorovanchi
- Zeinab Salehi*Zeinab Salehi*Email: zsalehy@ut.ac.irBiotechnology Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran 14147613131, IranMore by Zeinab Salehi
- Vahid Bazargan*Vahid Bazargan*Email: vbazargan@ut.ac.irMicroproteomics Research Laboratory, School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran 1439957131, IranMore by Vahid Bazargan
- Seyed Mohsen Ahmadi Tafti*Seyed Mohsen Ahmadi Tafti*Email: smahmadit@sina.tums.ac.irColorectal Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran 1419733141, IranMore by Seyed Mohsen Ahmadi Tafti
- Marco MarengoMarco MarengoDepartment of Civil Engineering and Architecture, University of Pavia, Pavia 27100, ItalyMore by Marco Marengo
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Abstract
Mesalamine (Mes) is a first-line anti-inflammatory agent extensively used to treat inflammatory bowel disease (IBD). Mes can be locally delivered using alginate-based microparticles as a pH-sensitive drug delivery system. In this study, we enhanced Alg microparticles by synthesizing an Alg-Kappa-carrageenan block copolymer using a biocompatible method with citric acid. The Alg-CA-κCar microparticles were fabricated on microfluidic chips and coated with chitosan (CS) to improve the encapsulation of Mes. FE-SEM images confirmed spherical microparticles with a narrow size distribution. TGA analysis showed better thermal stability for Alg-CA-κCar/CS microparticles compared with Alg microparticles. Alg-CA-κCar/CS microparticles achieved 73.8% drug encapsulation and demonstrated a pH-sensitive release profile with protection at pH 2 and increased release at pH 7.4. In vivo studies showed reduced pro-inflammatory factors such as TNF-α, MPO, and IL-6 levels in treated rats. Overall, Alg-CA-κCar/CS microparticles provide a more controlled carrier for Mes, demonstrating potential in effectively treating and managing the IBD.
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Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.
