Yes, the Sassoon family—Sephardic Jews from Baghdad who relocated to India—profited immensely from the 19th-century opium trade exporting from India to China, earning the nickname "Rothschilds of the East" for their Shanghai operations. However, they were not American Jews; the family operated as British subjects amid colonial trade networks. Their involvement was substantial but within a larger British-dominated system, not uniquely Jewish control.