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Corrigendum to “Rapamycin and Starvation Mitigate Indomethacin-Induced Intestinal Damage through Preservation of Lysosomal Vacuolar ATPase Integrity” [The Journal of Pharmacology and Experimental Therapeutics 390 (2024) 108–115]
Shunichi Yokoe, Department of Pharmacology, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.
Address correspondence to: Dr Michio Asahi, Department of Pharmacology, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.
In the above article, control images of normal small intestine were inadvertently duplicated in Figs. 4 and 5. The errors do not change the results or the conclusions presented in the article. The corrected Fig. 4 also includes a new version of Fig. 4B that is based on the new control image shown in Fig. 4A. A corrected Fig. 5 is also provided below.
The authors apologize for these errors and any inconvenience to the reader.
Fig. 4Indomethacin (IM) induces ulcers and inflammation in the mouse small intestine. (A) Histologic evaluation of small intestinal lesions caused by IM as visualized using Evans blue staining. The red circle highlights an ulcerated area. Scale bar, 5 mm. (B) Quantification of the ulcer ratio (ulcer area–to–total area) as depicted in (A). Values are presented as the mean ± SD (n = 4) (∗P < 0.05). (C) Histologic examination of small intestinal lesions due to IM using H&E staining. Scale bar, 5 mm. (D) Relative mRNA expression levels of interleukin 6 (IL-6) were determined in mouse hearts following IM treatment. Values are expressed as mean ± S.D. (n = 3) (∗P < 0.05). GADPH, glyceraldehyde-3-phosphate dehydrogenase.
Fig. 5Fasting or rapamycin (Rapa) mitigates indomethacin (IM)-induced small intestinal ulceration in mice. (A) Histologic examination of small intestinal lesions caused by IM administration, with or without Rapa, using Evans blue staining. Scale bar, 5 mm. (B) Histologic examination of small intestinal lesions caused by IM administration, with or without fasting, using Evans blue staining. Scale bar, 5 mm. (C) Quantification of the ulcer ratio (ulcer area–to–total area) as depicted in (A). Values are expressed as the mean ± S.D. (n = 4) (∗P < 0.05). (D) Quantification of the ulcer ratio (ulcer area–to–total area) as depicted in (B). Values are expressed as the mean ± S.D. (n = 4) (∗P < 0.05). (E) Histologic examination of small intestinal lesions caused by IM administration, with or without Rapa, using H&E staining. Scale bar, 100 mm. (F) Histologic examination of small intestinal lesions caused by IM administration, with or without fasting, using H&E staining. Scale bar, 100 mm. (G) Homogenates of the small intestine from IM-treated mice, with or without fasting or Rapa, were subjected to coimmunoprecipitation using the anti-V0d antibody. This was followed by western blotting with the anti-V1 A antibody. (H) Homogenates of the small intestine from IM-treated mice, with or without fasting or Rapa, were subjected to coimmunoprecipitation using the anti-V1A antibody, followed by western blot analysis with the anti-V0d antibody. IP, immunoprecipitation; Rapa, rapamycin.
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