Transcriptomic Profiling of Endothelial Progenitor Cells in Post-COVID-19 Patients: Insights at 3 and 6-Months Post-Infection
SUSTAINED ENDOTHELIAL DAMAGE POST-C19
Very interesting follow-up Spanish study with the BAD news for today!
Highlights:
•Transcriptomic profiling reveals long-term endothelial dysfunction in post-COVID-19.
•Enrichment analyses highlight disrupted pathways of endothelial homeostasis.
•Minimal changes between 3 and 6 months suggest sustained endothelial damage.
•Post-COVID patients with PE display unique profiles with reduced thrombosis markers.
"Overall, our findings identify differential expression patterns associated with disrupted
endothelial cell functions in ECFCs derived from post-COVID-19 patients."
"Our findings corroborate and expand upon existing evidence of endothelial dysfunction in COVID-19 patients, demonstrating decreased angiogenesis capacity, increased apoptosis, and
oxidative stress."
"This confirms persistent endothelial damage after recovery and may help explain certain pathological events observed in these individuals’ months or even years after infection."
As we’ve said this many times before, the acute C19 phase isn’t your big problem anymore, it’s the post-infectious period, the bodily scars C19 leaves that you need to worry about!
AVOID SARSCOV2/REINFECTIONS!
sciencedirect.com/science/articl
SUSTAINED ENDOTHELIAL DAMAGE POST-C19
Very interesting follow-up Spanish study with the BAD news for today!
Highlights:
•Transcriptomic profiling reveals long-term endothelial dysfunction in post-COVID-19.
•Enrichment analyses highlight disrupted pathways of endothelial homeostasis.
•Minimal changes between 3 and 6 months suggest sustained endothelial damage.
•Post-COVID patients with PE display unique profiles with reduced thrombosis markers.
"Overall, our findings identify differential expression patterns associated with disrupted
endothelial cell functions in ECFCs derived from post-COVID-19 patients."
"Our findings corroborate and expand upon existing evidence of endothelial dysfunction in COVID-19 patients, demonstrating decreased angiogenesis capacity, increased apoptosis, and
oxidative stress."
"This confirms persistent endothelial damage after recovery and may help explain certain pathological events observed in these individuals’ months or even years after infection."
As we’ve said this many times before, the acute C19 phase isn’t your big problem anymore, it’s the post-infectious period, the bodily scars C19 leaves that you need to worry about!
AVOID SARSCOV2/REINFECTIONS!
sciencedirect.com/science/articl