Nobuhiro Ariyoshi MD

$The image features a clean, well-lit academic article titled "Why the Days Seem Shorter as We Get Older" by Adrian Bejan, published in the European Review, Vol. 27, No. 2, 2019. It includes the author\'s name, affiliation (Duke University, Department of Mechanical Engineering and Materials Science, Durham, North Carolina, USA), and email. The text discusses the scientific basis for why time feels faster with age, linking it to reduced noticeable events perceived by the brain. No platform watermarks like Instagram, TikTok, or Xiaohongshu are present, and the composition is straightforward, focusing on the article\'s title and abstract.$

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Nobuhiro Ariyoshi MD

@AriyoshiMd

Aug 4

大事なプレゼンや試験、面接など、心理的ストレスを感じる前には、「少しキツめ（やや汗ばむ程度）」の運動がおすすめ・強めの運動（約70％の運動強度で30分）をすると、その後のストレスによるコルチゾール分泌が抑えられ、精神的に落ち着く

$The image is a screenshot of a scientific journal article titled "Psychoneuroendocrinology" from Elsevier, featuring a study on exercise and stress. It includes the journal\'s logo, publication details, and abstract text discussing a 30-minute intense exercise (about 70% intensity) reducing cortisol secretion and stress responses. The layout is formal, with black text on a white background, and includes the Elsevier watermark. The post text by Nobuhiro Ariyoshi MD (@AriyoshiMd) recommends moderate, sweat-inducing exercise before stressful events like presentations or exams, aligning with the study\'s findings on stress management and mental calmness.$

【カフェインは“何時間前”までOK？

】（就寝22:00を想定）

紅茶1杯 (47 mg) → ほぼ影響なし＝直前でもOK

コーヒー1杯 (107 mg) → 9時間前まで（13:00がリミット）

プレワークアウト※ (217 mg) → 13時間前まで（09:00がリミット）

The image is a screenshot of a scientific journal article titled "The effect of caffeine on subsequent sleep: A systematic review and meta-analysis" published in Sleep Medicine Reviews. The article is authored by Carissa Cardinal, Jonathan Weakley, and others, with affiliations to various Australian research institutions. The abstract discusses the impact of caffeine on sleep, highlighting that caffeine intake close to bedtime can impair sleep quality. The post text by Nobuhiro Ariyoshi MD provides practical advice on when to consume caffeine before sleep, suggesting that a cup of tea is fine right before bed, while coffee should be consumed at least 9 hours prior, and pre-workout supplements with high caffeine content should be taken 13 hours before sleep. This context enhances the understanding of the image by linking the scientific findings to practical lifestyle advice.

大腸がん手術＋化学療法後に、早歩きなど中強度の運動を週3〜4回、3年続けると、再発・新規がん・死亡リスクが約30％下がり、8年生存率も＋7％↑。運動で薬並みの効果

The image is a screenshot of a scientific article from 'The New England Journal of Medicine' titled 'Structured Exercise after Adjuvant Chemotherapy for Colon Cancer'. The article discusses a study where patients who engaged in moderate-intensity exercise like brisk walking 3-4 times a week for 3 years after colon cancer surgery and chemotherapy showed a significant reduction in the risk of cancer recurrence, new cancers, and death by about 30%, with an increase in 8-year survival rate by 7%. The post by Nobuhiro Ariyoshi MD highlights these findings, emphasizing the substantial health benefits of regular exercise post-treatment. The image includes the abstract of the study, detailing the methodology and results, and is presented in a clear, professional layout typical of medical journal articles.

「大切な人を失った直後」に心筋梗塞リスクが急上昇・最愛の人を亡くした直後24時間以内の心筋梗塞リスクは、なんと21倍・リスクは日を追って低下「悲しみは心を壊す」だけでなく、文字通り“心臓”を壊す可能性がある

A bar graph showing incidence rate ratio on a log scale from 0.25 to 32. Bars represent different time periods after the death of a significant person: less than 1 day, 1-2 days, 2-3 days, 3-7 days, and 7-30 days. The highest bar, at around 16, corresponds to less than 1 day, with decreasing heights for subsequent periods.

【アルブミン製剤 2024 ICTMGガイドライン超要約：JAMA】推奨は実質この2シーンのみ・肝硬変＋大量腹水穿刺 >5 L ・肝硬変＋特発性細菌性腹膜炎（SBP）以下では「使わない」推奨・低Alb（<3 g/dL）を補う目的だけ・ICUで利尿を強める目的・一般的な低血圧／容量不足への補液

The image is a screenshot of a medical guideline summary from the JAMA Clinical Guidelines Synopsis titled "Use of Intravenous Albumin". It details the recommendations for the use of intravenous albumin in specific clinical scenarios, particularly in patients with liver cirrhosis and large volume paracentesis or spontaneous bacterial peritonitis (SBP). The text highlights that albumin should not be used for general purposes like correcting low albumin levels, enhancing diuresis in ICU, or treating general hypotension or volume depletion. The post by Nobuhiro Ariyoshi MD provides a concise summary in Japanese, emphasizing the limited recommended uses of albumin in 2024 ICTMG guidelines.

筋肉が“すい臓がん”を防ぐ？ UK Biobank（36万人超）を13.7年追跡した研究・筋肉量が多い人：すい臓がんリスク14％↓ ・握力が強い人：リスク10％↓ ・男性では筋肉量、女性では握力がより重要・糖尿病・肥満の人でも効果あり 5〜12％のすい臓がんが「筋肉づくり」で予防できる可能性あり

A research paper titled "Muscle strength and mass as predictors of pancreatic cancer: insights from the UK Biobank" with text detailing a study of over 360,000 participants followed for 13.7 years. The paper includes sections labeled "RESEARCH Open Access," "Abstract," and "Background" with scientific data on muscle mass, grip strength, and pancreatic cancer risk reduction. A watermark from BMC Cancer is visible.

米国の研修医にとって、「遅くまで残る＝熱心」ではなく、「定時で終わらせる＝仕事ができる」が評価基準。私が米国に来たての頃、カルテを丁寧に書こうとして夜10時までカルテを書いていたら「効率が悪い」と評価↓ ・残業は努力ではなく “システムの問題” ・限られた時間で結果を出すことが大事

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川北哲也

@TetsuyaKawakit

Jun 5

アメリカのレジデンシーは完全シフト制。定時で帰るのが当たり前。レジデント時代、日本の感覚で「勉強のために残ります！」と手術に入ってたら、上級医に「何してんの、早く帰れ！」と本気で怒られたのは今でも忘れられません。

体重より「どれだけ動けるか」が大事 1980〜2023年の20の研究、約40万人分のデータをまとめた結果：・たとえ太っていても、体力がある人は死亡リスクが高くない・逆に、体重に関係なく体力がない人は死亡リスクが2〜3倍に体重だけを気にするより、まず体力をつけることが健康への近道

The image is a screenshot of a scientific review article titled "Cardiorespiratory fitness, body mass index and mortality: a systematic review and meta-analysis" by Nathan R. Weelsdreyer, Jason C. De Guzman, Craig Paterson, and Jason D. Allen, published in Open Access. It features a structured layout with sections like "ABSTRACT," "WHAT IS ALREADY KNOWN," and "WHAT ARE THE NEW FINDINGS," discussing the relationship between fitness, body mass, and mortality risk. The post text by Nobuhiro Ariyoshi MD emphasizes that physical fitness is more critical than body weight for health, referencing data from 1980–2023 involving 400,000 people, showing lower mortality risks for fit individuals regardless of weight. No platform watermarks are visible.

ヒトの臓器を50年間追跡したタンパク質の地図・50歳前後に老化が一気に加速・特に血管は早く老化しやすい・老化が進むとタンパク質のバランスが崩れ、アミロイドが蓄積・血液中には臓器由来の老化タンパク質（例:GAS6）が流れ、全身の老化を促進

The image is a scientific article abstract from "Cell" titled "Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures." It features a graphical abstract with circular diagrams representing human organs and aging processes, including vasculature and systemic aging. The post text by Nobuhiro Ariyoshi MD (@AriyoshiMd) highlights a 50-year study tracking protein changes in human organs, noting accelerated aging around age 50, early vascular aging, protein imbalances, amyloid accumulation, and aging proteins like GAS6 in blood. No platform watermarks are present.

【大人になってからの運動量が寿命を左右】・成人後に運動習慣を維持・増加した人は、死亡リスクが最大30〜40%低下・運動不足だった人も、途中から運動を始めるだけで、死亡リスクは20〜25%減少・心血管系の死亡リスク低下は特に明確・がん死亡リスク低下の効果はやや弱め

本番前に「落ち着け」と言っても、心臓バクバクは止まらない。でも「ワクワクしてる！」と言うだけで、歌・スピーチ・計算テストの成績がアップする。不安と興奮はどちらも“覚醒状態”。ならば、無理に落ち着くより、興奮に乗っかる方がパフォーマンスを高めやすい。

A document page from the "Journal of Experimental Psychology: General" featuring the title "Get Excited: Reappraising Pre-Performance Anxiety as Excitement" by Allison Wood Brooks, Harvard Business School. The text includes keywords like anxiety, excitement, reappraisal, emotion regulation, and arousal congruency.

糖尿病治療薬であるメトホルミンは、脳に作用して血糖値を下げることが判明。脳の視床下部にある「Rap1」というタンパク質の働きを抑えることが、効果の重要なポイント。これまで肝臓や腸が主な作用場所とされていましたが、新たに脳の役割が注目されています

$The image is a screenshot of a research article from "Science Advances" focused on neuroscience, featuring a title about metformin\'s antidiabetic action via the brain\'s Rap1 protein. It includes author names like "Nobuhiro Ariyoshi" and affiliations, with a clean, academic layout in black text on a white background. The post text by Nobuhiro Ariyoshi MD (@AriyoshiMd) explains metformin\'s role in lowering blood sugar by targeting the hypothalamus\' Rap1 protein, highlighting the brain\'s new role in its effects. No platform watermarks are present, and the composition is professional, emphasizing scientific discovery.$

なぜマンジャロはオゼンピックより効くのか？それは、GIPが“脳への道”を広げるから。 GLP-1薬は、視床下部の「バソプレシン神経」に届くことで体重減少を起こします。その“通り道”にあるオリゴデンドロサイト（グリア細胞）にGIPが作用すると、　① 髄鞘のリモデリング　② 血管の柔軟性↑ 　③

$The image is a scientific graphical abstract from a Cell Metabolism article, featuring a diagram of GLP-1R and GLP-1R/GIP co-agonism pathways in oligodendrocytes, illustrating weight loss mechanisms. It shows two pathways: GLP-1R alone and GLP-1R/GIP co-agonism, with arrows indicating effects like myelin remodeling, vascular flexibility, and enhanced GLP-1 access to the brain. The post text by Nobuhiro Ariyoshi MD explains how GIP in Mounjaro enhances Ozempic\'s weight loss by improving GLP-1 drug access to hypothalamic vasopressin neurons via oligodendrocyte action. No platform watermarks are present, and the composition is clear, well-organized, and technically sound.$

高齢になると免疫は弱くなるのに、自己免疫疾患（巨細胞性動脈炎など）は増える。その理由の一つは「免疫が若すぎること」。若いT細胞＋抑制の効かない免疫＋加齢によって生じる新たな自己抗原が自己免疫を引き起こす。

$The image is a screenshot of a webpage from the journal "Nature Aging," featuring an article titled "Sustained immune youth risks autoimmune disease in the aging host" by Cornelia M. Weyand & Jörg J. Goronzy, published on 14 August 2025. The layout includes the journal\'s logo, navigation options (Explore content, About the journal, Publish with us, Subscribe), and article details in blue and black text on a white background. The post text by Nobuhiro Ariyoshi MD explains that sustained youthful immunity in aging can increase autoimmune disease risk, like giant cell arteritis, due to young T cells, unchecked immunity, and new self-antigens from aging, suggesting moderate immune aging might protect against autoimmunity. No platform watermarks are present.$

夜勤は免疫の“体内時計”を乱す・看護師191人の研究で、夜勤者は睡眠5.4時間、睡眠負債+3.2時間、社会的時差（仕事時間と体内時計のズレ）6.7時間・結果、免疫（細胞や炎症マーカーなど）の1日リズムが昼夜逆転感染しやすく、ワクチン効果が下がるおそれあり

$The image is a screenshot of a scientific article from Frontiers in Immunology, featuring a clean, professional layout with the title "Immune disruptions and night shift work in hospital healthcare professionals: The intricate effects of sleep debt and social jet-lag." It includes author names like Brice Faraut, Emilie Cordier-Duverger, Catherine Drogou, and Damien Leger, listed with their affiliations. The text highlights a study on 191 nurses, showing night shift workers have 5.4 hours of sleep, a sleep debt of +3.2 hours, and a social jet lag of 6.7 hours, disrupting immune rhythms. The post by Nobuhiro Ariyoshi MD on X emphasizes that night shifts disrupt the immune system\'s "biological clock," potentially increasing infection risk and reducing vaccine efficacy. No platform watermarks are present.$

高齢者は入院をきっかけに、歩く・立ち上がるなどの日常動作を失いやすく、実際に3人に1人が退院後に自立を失うというデータも最新の研究によると、退院後に筋トレや有酸素運動を続けた人は、身体機能が大きく改善退院時には「運動処方」と継続できる支援体制（自宅・訪問・オンライン）が大切

$The image features a scientific article titled "Effectiveness of post-discharge exercise interventions in older adults following acute hospitalization: a systematic review" by Pablo Lomas-Vega et al., published in the journal "Age and Ageing." It includes a header with the article title, author names, and publication details, alongside a small icon or logo, possibly from the journal or platform. The post text by Nobuhiro Ariyoshi MD emphasizes the importance of exercise like muscle training and aerobic activities for elderly individuals post-hospitalization to maintain physical function and independence, aligning with the article\'s focus on rehabilitation and physical therapy for older adults. No platform watermarks like Instagram, TikTok, or Xiaohongshu are visible.$

【1日7,000歩が最も効果的？：大規模メタ解析】 1日7,000歩は2,000歩に比べて、・全死亡リスク：47%↓ ・心血管疾患の発症：25%↓ ・心血管疾患による死亡：47%↓ ・認知症リスク：38%↓ ・うつ症状のリスク：22%↓ ・転倒リスク：28%↓

$The image features a scientific article titled "Daily steps and health outcomes in adults: a systematic review and meta-analysis" from the journal "The Lancet Public Health," published in 2023. It includes a detailed table or graph summarizing health benefits of walking 7,000 steps daily, such as reduced risks of mortality, cardiovascular disease, dementia, depression, and falls, as highlighted in Nobuhiro Ariyoshi MD\'s post. The layout is academic, with small text, charts, and references to studies, set against a white background. No platform watermarks like Instagram, TikTok, or Xiaohongshu are present, and the post text integrates the image\'s data to emphasize 7,000 steps as an optimal, achievable health goal.$

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