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ReviewVolume 22, Issue 3p255-267March 2023

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Carpal tunnel syndrome: updated evidence and new questions

Prof Luca Padua, MD PhD
Correspondence
Correspondence to: Prof Luca Padua, Fondazione Policlinico Universitario A Gemelli IRCCS, 00168 Rome, Italy
Affiliations
Department of Geriatrics and Orthopaedics, Università Cattolica del Sacro Cuore, Rome, Italy
UOC Neuroriabilitazione Alta Intensità, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
a,b luca.padua@unicatt.it
Cristina Cuccagna, MD
Affiliations
UOC Neuroriabilitazione Alta Intensità, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
b
Silvia Giovannini, MD PhD
Affiliations
Department of Geriatrics and Orthopaedics, Università Cattolica del Sacro Cuore, Rome, Italy
UOS Riabilitazione Post-Acuzie, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
a,c
Daniele Coraci, MD PhD
Affiliations
Department of Neuroscience, Section of Rehabilitation, University of Padova, Padua, Italy
e
Luciana Pelosi, MD PhD
Affiliations
Departments of Neurology and Neurophysiology, Bay of Plenty District Health Board, Tauranga Hospital, Tauranga, New Zealand
f
Claudia Loreti, PhD
Affiliations
Department of Aging, Neurological, Orthopaedic and Head-Neck Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
d
Roberto Bernabei, MD PhD
Affiliations
Department of Geriatrics and Orthopaedics, Università Cattolica del Sacro Cuore, Rome, Italy
Department of Aging, Neurological, Orthopaedic and Head-Neck Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
a,d
Prof Lisa D Hobson-Webb, MD
Affiliations
Department of Neurology, Neuromuscular Division, Duke University, Durham, NC, USA
g
∙ et al. Show more

Summary

Carpal tunnel syndrome is the most common entrapment neuropathy, affecting quality of life for many people. Although it is a well recognised condition, new insights into epidemiology, diagnosis, and treatment have emerged in the past 6 years. The availability of disease-modifying treatments for rare systemic disorders associated with carpal tunnel syndrome (eg, amyloidosis) should alert clinicians to these diagnostic possibilities. Besides clinical evaluation and electrophysiology, the role of ultrasonography as a diagnostic tool has been confirmed and new ultrasound techniques have been applied, the clinical use and feasibility of which require further investigation. Surgical and non-surgical interventions are beneficial for the treatment of carpal tunnel syndrome and several treatment options are now available, giving clinicians the possibility to choose the best approach for every patient. New diagnostic and therapeutic techniques require further validation.

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