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I took a peptide called bpc 157 and am now reading that it can mess with your serotonin and dopamine receptors including
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Customer: I took a peptide called bpc 157 and am now reading that it can mess with your serotonin and dopamine receptors including 5h2a receptor, very concerned as I accidentally took too much for a bit
Doctor's Assistant: The Neurologist can help. Just a couple quick questions before I transfer you. Do you have frequent headaches? Any issues with coordination or balance?
Customer: No
Doctor's Assistant: Have your parents or grandparents had any neurological conditions? If so, who and which ones?
Customer: No
Doctor's Assistant: OK. Thanks for the info. And, how would you like to connect with the Doctor - phone call or online chat?
Customer: Phone
Doctor's Assistant: The Neurologist can help. Just a couple quick questions before I transfer you. Do you have frequent headaches? Any issues with coordination or balance?
Customer: No
Doctor's Assistant: Have your parents or grandparents had any neurological conditions? If so, who and which ones?
Customer: No
Doctor's Assistant: OK. Thanks for the info. And, how would you like to connect with the Doctor - phone call or online chat?
Customer: Phone
Answered by Albert M.D. in 5 mins 1 year ago
Specialities include: Medical
Hi, I'm ******, a Neurologist, calling from JustAnswer. I'm here to help you today.
Customer
I think I lost you for a moment.
Sorry about that, I got disconnected. For short-term use, an increase in dosage wouldn't be a major concern. However, if you're experiencing longer-term effects that are legitimate and not just in your head, then I'd be more concerned. Are you experiencing any jitters or feeling more sensitive to things?
Customer
It's more like I have less body sensation than usual, and I'm experiencing some depersonalization. But who's to say that's not psychotic, right?
Right. Are you taking any other supplements or medications that might be causing this? It's important to know because supplements can interact with other things, even something as simple as aspirin.
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Customer
I wasn't taking anything else, maybe some antibiotics, but I can't remember. The higher dosage was recommended for a few weeks, but I only took it for a few days, maybe five at most.
Okay, so it was a short duration. I'm looking into the research, and I found an article about excretion and half-life. Half-life is how long it takes for a substance to reduce to 50% of its original concentration in the body. For example, in rats, the average elimination half-life is 15.2 minutes. This means that after 15 minutes, only 50% of the substance remains in the plasma. After another 15 minutes, it's down to 25%, and so on. So even if you took four times the recommended dose, it would be back to normal levels within about half an hour.
Customer
Right, so it's cleared from the body pretty quickly.
Yes, for most people, it would be cleared within four hours. The effects on the body shouldn't continue for a long time after it's out of the system. These studies were mainly done on rats and dogs, but pharmacokinetics generally wouldn't be drastically different in humans. It might vary a little, but not by a factor of a hundred.
Customer
Okay, so I shouldn't be too worried about long-term effects.
I wouldn't worry too much. I found this article on PubMed, a great resource for research articles. I can send it to you if you'd like. It's a bit wordy, but it explains the pharmacokinetics in more detail.
Customer
Oh yeah, that would be great. One thing that freaks me out is that I read something about the 5H2A receptor. This supplement does something to that receptor, and I'm worried because I know it can be involved with dementia and Alzheimer's.
Yes, it could potentially have an effect on that receptor. However, I'd be more concerned if you were taking it for years at high doses. Even with recreational drugs like MDMA, long-term use can cause anhedonia and loss of interest. But for a short duration like yours, I wouldn't worry about it.
Customer
Well, I definitely wasn't tripping on it. The only thing I noticed was some mood issues, not hallucinations or anything like that. So if it did something to that receptor, I would have noticed something significant happening, right?
Yes, you would have noticed. And not just you, your friends and family would have commented on any significant changes in your behavior. It's hard to say for sure because there isn't a lot of research on this supplement. Unfortunately, this is a problem with some supplements that make claims without sufficient evidence. But they have done legitimate pharmacokinetic analysis, so I'm not overly concerned.
Customer
Okay, yeah. Everything I saw was anecdotal. There was a period where I was super down, but that wasn't even when I was on the supplement. It was more like irritation.
Right. I'm not saying that if you had taken a lot more for a longer period of time, you wouldn't have experienced some short-term effects. But it should be cleared from your body within a day, even if you took a quadruple dose. It won't build up in your system. So I think you're okay. This might be a lesson learned about being careful with dosage and how you use supplements. It's like any medicine, if you accidentally take a handful of aspirin instead of one, it can be toxic. It's not just about supplements, it's about anything. I'm not that worried at all. I'll send you the link to the article I mentioned. It's a bit wordy, but it explains the pharmacokinetics.
Customer
Okay, I'm never taking any of these supplements again. On a different note, do you know what PFA is? PFA salsa, trifluoroacetate.
Trifluoride. I'm not familiar with that at all.
Customer
It seems like it's sometimes used for peptides in the salt form. Some sources say it's toxic, but it depends on whether it's the acid or the salt. They say it can burn your skin. This was an injectable, so I feel like I would have noticed something pretty messed up if it was toxic.
I haven't heard of that much. I'm looking through PubMed, a great resource for medical research. I wouldn't recommend injecting things you don't know much about, especially if there's limited evidence. A lot of these things aren't regulated, so it's hard to know what you're getting. But, you know, you're not the only one who's been in this situation.
Customer
Oh yeah, I know. It was a stressful time for me. I'm particular about things like vegetable oils, but I have a friend who's a nurse who takes peptides, and other people I know have done it. They said I should try it. I tried TB 500 and another peptide together. There are endocrine doctors and experts talking about it, compounding pharmacies, and all that. So I thought, okay, it must be okay. But looking back, I'm like, what the heck was I doing? Injecting stuff I heard about on the internet?
I understand. It's not that some people in the medical profession are doing harmful things, it's just that there are claims made that can't be verified. If they were, the research would be out there for us to see. The FDA has its reasons for requiring verification of claims. The doctors and nurses you know may truly believe in some of this stuff, but as a doctor, I follow the evidence. I need to be able to read the evidence to support claims. Even with this article I found, it's great that it talks about rats and dogs, but I'd want to see human studies as well. We all want to find something that works, but then you realize you need more information. It's hard to find.
Customer
Yeah, you get into the comment rabbit hole. All the research articles I read were positive, saying it was modulatory and miraculous. It seemed like it fixed everything that was dysfunctional and didn't touch anything that didn't need to be touched.
Right. It's great that it shows promise, and maybe one day it will be a standard of care supplement for wound healing. But right now, it's not considered standard of care. It's a frontier we don't know much about. I'm sure they're studying it in humans. But based on what I know, if you took it orally, it should be cleared from your system. My guess is it's cleared renally, meaning through the kidneys. If it's cleared through the kidneys, you'll pee it out within a day.
Customer
It looks like they started human trials, but then they stopped them. People were worried it messed people up, but it could have been a funding issue.
Right. It could be as simple as it didn't work, and the people who wanted to do the studies didn't want that to come out. If it doesn't work, it's off the market. You never really know. I'm looking at the article, and it looks like it's excreted in urine and bile. So you'll poop and pee it out within a day.
Customer
Well, yeah. I tried the injectable one. Who's to say that if I ordered something online, they wouldn't give me something super insane that does the same thing? I'd rather have something that just... It's not like I shot myself up with arsenic or something, right?
Right, right. You learned a lesson. We all get to that point where we want something to happen faster, but these regulations exist for a reason. Western medicine might be a little behind the curve, but the body is still the body. As long as you're not putting something really toxic in, and you're getting what you think you're getting, it should be okay. The body has a remarkable ability to heal and get rid of stuff it doesn't need.
Customer
That's the way I like to think about it. Okay, because I'm very paranoid about, oh my god, did I know...
I understand. I wouldn't personally or professionally take something that I didn't have clear evidence of what it's supposed to do, especially long-term. The data isn't there about what could happen in 20 years if you take it every day.
Customer
Yeah, so if I did it for six weeks, it's not like I'm going to see something messed up happen 20 years down the line from something I did for that short of a time.
Right. Most things aren't that toxic that way. But that's the danger of the supplement world. You could be getting powdered sugar, or you could be getting something that doesn't do what it's supposed to do. This is the problem when you use stuff that doesn't have the backing of science, especially in vivo models, which are human studies. This is more in vitro or animal model stuff. If the human model isn't presented properly, I can't say anything about what it's supposed to do.
Customer
Yeah, I saw something saying it might be cancer-promoting, but that's because of the angiogels it does.
A lot of that is theoretical. I wouldn't take too much into consideration until you find a lot of data from legitimate sources. If you find a tremendous amount of data from, say, 50,000 dogs, then I'd be more worried. That's why things don't make it to phase one, phase two, phase three trials. If it does something in dogs, people don't want it to do the same thing in humans, even if it's just a possibility.
Customer
So the fact that it even got to human trials is pretty big at that point.
Yeah, I think the worst thing is that they'll find it does nothing.
Customer
Yeah, well, I appreciate your time. What was your background again?
I'm an internal medicine physician and a board-certified hospitalist. I treat a lot of general things, but I also see a lot of overdoses and those sorts of things in the ER.
Customer
Oh, wow. Well, I appreciate your time, man. Thank you.
No problem. Best of luck. I'll send you the link to the article right after this.
Customer
Appreciate it.
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Disclaimer: The customer and expert messages presented herein may have been altered or modified to enhance readability and safeguard the privacy of individuals. These modifications do not change the intent or substance of the original messages.
Concerns About BPC 157 and Neurotransmitter Effects
Worries about receptor impact and potential side effects from peptide misuse.
BPC 157 is a peptide under research for healing properties, but its effects on serotonin and dopamine receptors like 5-HT2A are not fully understood. Taking higher doses than recommended may increase risks of side effects or interactions. It is advisable to stop use and consult a healthcare provider for evaluation and guidance. Monitoring symptoms and avoiding self-adjusting doses can help ensure safety while more evidence emerges about this peptide’s neurological impact.
Disclaimer: This information is AI-generated and intended for general guidance only. For advice specific to your situation, please consult a verified expert on JustAnswer before making decisions.
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