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Artificial Intelligence in Plain English

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Build Multi-Agent AI Systems with Agno: A Complete Guide

7 min readJun 9, 2025

Imagine you’re planning a dream vacation to Japan. You need someone to find the best flights, another to scout perfect accommodations, a food expert to recommend authentic restaurants, a local guide for must-see attractions, and a budget specialist to keep everything affordable. Each “agent” has their specialty, but they need to work together seamlessly to create your perfect trip.

This is exactly what multi-agent systems do in the AI world — and today, I’ll show you how to build them using Agno, a powerful framework that makes creating intelligent, collaborative AI agents surprisingly simple.

What Makes Agno Special?

Agno is a full-stack framework for building Multi-Agent Systems with memory, knowledge, and reasoning. Think of it as the orchestrator that helps different AI agents work together, remember past interactions, access specialized knowledge, and make intelligent decisions.

What sets Agno apart from other AI frameworks? Here are the key features that make it a game-changer:

  • Model Agnostic: Works with 23+ model providers — no vendor lock-in
  • Lightning Fast: Agents instantiate in ~3μs and use ~6.5KB memory on average
  • Reasoning First: Built-in reasoning capabilities for…

Artificial Intelligence in Plain English

Published in Artificial Intelligence in Plain English

New AI, ML and Data Science articles every day. Follow to join our 3.5M+ monthly readers.

Divyansh Bhatia

Written by Divyansh Bhatia

I turn AI and LLM research into action, connecting innovation with business goals for real-world success

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