The use of non-deterministic database languages is motivated using pragmatic and theoretical considerations. It is shown that non-determinism resolves some difficulties concerning the expressive power of deterministic languages: there are non-deterministic languages expressing low complexity classes of queries/updates, whereas no such deterministic languages exist. Various mechanisms yielding non-determinism are reviewed. The focus is on two closely related families of non-deterministic languages. The first consists of extensions of Datalog with negations in bodies and/or heads of rules, with non-deterministic fixpoint semantics. The second consists of non-deterministic extensions of first-order logic and fixpoint logics, using the witness operator. The ability of the various non-deterministic languages to express deterministic transformation is characterized. In particular, non-deterministic languages expressing exactly the queries/updates computable in polynomial time are exhibited, whereas it is conjectured that no analogous deterministic language exists. The connection between non-deterministic languages and determinism is also explored. Several problems of practical interest are examined, such as checking (statically or dynamically) if a given program is deterministic, detecting coincidence of deterministic and non-deterministic semantics, and verifying termination for non-deterministic programs.