Honors & Awards

  • Berry Fellowship, Berry Foundation (Sep 2024 - Aug 2027)
  • 25th Christoph-Schmelzer-Award for outstanding PhD theses related to tumor therapy with ion beams, GSI Helmholtz Centre for Heavy Ion Research (Nov 2023)
  • Best PhD award in Medical Physics 2023, German Society of Medical Physics (DGMP) (Sep 2023)
  • Best PhD award in Applied Physics 2023, Swiss Physical Society (Sep 2023)
  • Varian Recognition Award 2022 for best research paper in medical physics, Swiss Society of Radiation Biology and Medical Physics (SSRMP) (Oct 2022)
  • PTCOG 2022 Travel Fellowship, PTCOG (June 2022)
  • European Student Grant for IPAC 2022, European Physical Society (June 2022)
  • Best Poster Award, 4D treatment workshop on particle therapy, Delft, The Netherlands (Nov 2021)
  • European Student Grant for IPAC 2021, European Physical Society (June 2021)
  • Nuclear Innovation Scholarship, IMT foundation (July 2017)
  • IMT Challenge 2017 Airbus Award (for Best Start-up Idea), École Nationale Supérieure des Mines, France (June 2017)
  • Travel Grant to participate in ICTP/IAEA Nuclear Energy Management School, International Atomic Energy Agency (IAEA) (Oct 2016)
  • J. N. Tata Scholar (Scholarship for master studies), J. N. Tata Foundation (Sep 2016)
  • Excellence Scholarship, IMT Atlantique, Nantes, France (Sep 2016)
  • Nuclear Olympiad 2015, Third Rank, IAEA, Vienna, Austria, World Nuclear Association (Sep 2015)
  • Robert J. Sorenson Scholarship 2014 (Best Student Member of the Year 2014), Institute of Nuclear Materials Management, Atlanta, USA (July 2014)
  • Partnership for Nuclear Security Scholarship for an exchange program with Texas A&M University, USA, US Department of State (May 2014)
  • Travel Grant to participate in IAEA-ICTP School on Nuclear Security, International Atomic Energy Agency (IAEA) funding (April 2024)
  • Partnership for Nuclear Security Scholarship to participate in School on Radiation Technology, US Department of State (March 2014)
  • Travel Scholarship to participate in American Nuclear Society Winter Meeting, US Department of State (Nov 2013)
  • Travel Scholarship for PATRAM 2013 annual meeting, US Department of State (Sep 2013)
  • Young Scientist Scholarship, Science and Engineering Research Board (SERB), Government of India. (April 2013)
  • Graduate Aptitude Test in Engineering Scholarship, Government of India (July 2012)
All Honors & Awards (23)

Professional Education

  • Doctor of Science, ETH Zurich, Physics (2023)

Patents

  • Vivek Maradia. " Patent EP21173019 Compact beam transport system for multi-room particle therapy facility", May 12, 2022
  • Vivek Maradia. " Patent EP21163081 A particle beam transport system for the delivery of particle beam therapy", Mar 18, 2022
  • Vivek Maradia. " Patent EP21185726 Optimized matching of beam emittance and collimation system to maximize transmission through beamline", Jul 15, 2021

Contact

  • Academic
    maradia@stanford.edu
    University - Scholar Department: Radiation Oncology Position: Postdoctoral Scholar

Additional Info

Current Research and Scholarly Interests

My current focus lies in the simulation and experimental implementation of ultra-high dose rate delivery utilizing proton, x-ray, and electron beams for FLASH preclinical studies, with potential applications in clinical research.

Within this domain, I am deeply engaged in exploring the dynamic interplay between various parameters such as beam energy, dose rate, and biological response. Through a combination of computational modeling and hands-on experimentation, I endeavor to unravel the underlying mechanisms governing the efficacy and safety of ultra-high dose rate delivery systems.

By delving into the intricacies of FLASH preclinical studies, my efforts are directed towards unlocking transformative insights that could revolutionize the landscape of cancer therapy. These endeavors pave the way for the development of innovative treatment modalities with the potential to redefine standards of care and enhance patient outcomes in the realm of oncology.

Additionally, drawing upon the valuable insights garnered from the beamline upgrade at PSI's PROScan facility, I am spearheading the design of a compact cyclotron-based proton therapy infrastructure. This innovative design is envisioned to be versatile enough to accommodate conventional radiation therapy bunkers or multi-room facilities akin to tennis courts.

All Publications

  • Demonstration of momentum cooling to enhance the potential of cancer treatment with proton therapy (vol 19, pg 1437, 2023) NATURE PHYSICS Maradia, V., Meer, D., Dolling, R., Weber, D. C., Lomax, A. J., Psoroulas, S. 2024 More

    View details for DOI 10.1038/s41567-024-02555-4

    View details for Web of Science ID 001235060600001

  • New cyclotron-based proton therapy facility development to achieve conformal FLASH treatment plans Maradia, V., van de Water, S., Weber, D., Lomax, A. ELSEVIER IRELAND LTD. 2024: S4636-S4638 More

    View details for Web of Science ID 001331355605236

  • Demonstration of momentum cooling to enhance the potential of cancer treatment with proton therapy NATURE PHYSICS Maradia, V., Meer, D., Doelling, R., Weber, D. C., Lomax, A. J., Psoroulas, S. 2023 More

    View details for DOI 10.1038/s41567-023-02115-2

    View details for Web of Science ID 001021384800002

  • Momentum cooling can improve transmission rates for proton therapy NATURE PHYSICS Maradia, V., Psoroulas, S. 2023 More

    View details for DOI 10.1038/s41567-023-02116-1

    View details for Web of Science ID 001021384800001

  • Ultra-compact and highly efficient proton therapy: Design considerations and clinical simulations Maradia, V., Meer, D., van de Water, S., Verbakel, W., Weber, D. C., Lomax, A. J., Psoroulas, S. ELSEVIER IRELAND LTD. 2023: S189-S190 More

    View details for Web of Science ID 001043659000216

  • A novel method of emittance matching to increase beam transmission for cyclotron-based proton therapy facilities: simulation study Journal of Physics: Conference Series Maradia, V., Meer, D., Lomax, A. J., Schippers, J. M., Psoroulas, S. 2023 More

    View details for DOI 10.1088/1742-6596/2420/1/012107

  • A novel intensity compensation method to achieve energy independent beam intensity at the patient location for cyclotron based proton therapy facilities Journal of Physics: Conference Series Maradia, V., Meer, D., Lomax, A. J., Psoroulas, S. 2023; 2420 (1) More

    View details for DOI 10.1088/1742-6596/2420/1/012106

  • Universal and dynamic ridge filter for pencil beam scanning particle therapy: a novel concept for ultra-fast treatment delivery. Physics in medicine and biology Maradia, V., Colizzi, I., Meer, D., Weber, D. C., Lomax, A. J., Actis, O., Psoroulas, S. 2022; 67 (22) More

    Abstract

    Objective.In pencil beam scanning particle therapy, a short treatment delivery time is paramount for the efficient treatment of moving targets with motion mitigation techniques (such as breath-hold, rescanning, and gating). Energy and spot position change time are limiting factors in reducing treatment time. In this study, we designed a universal and dynamic energy modulator (ridge filter, RF) to broaden the Bragg peak, to reduce the number of energies and spots required to cover the target volume, thus lowering the treatment time.Approach. Our RF unit comprises two identical RFs placed just before the isocenter. Both RFs move relative to each other, changing the Bragg peak's characteristics dynamically. We simulated different Bragg peak shapes with the RF in Monte Carlo simulation code (TOPAS) and validated them experimentally. We then delivered single-field plans with 1 Gy/fraction to different geometrical targets in water, to measure the dose delivery time using the RF and compare it with the clinical settings.Main results.Aligning the RFs in different positions produces different broadening in the Bragg peak; we achieved a maximum broadening of 2.5 cm. With RF we reduced the number of energies in a field by more than 60%, and the dose delivery time by 50%, for all geometrical targets investigated, without compromising the dose distribution transverse and distal fall-off.Significance. Our novel universal and dynamic RF allows for the adaptation of the Bragg peak broadening for a spot and/or energy layer based on the requirement of dose shaping in the target volume. It significantly reduces the number of energy layers and spots to cover the target volume, and thus the treatment time. This RF design is ideal for ultra-fast treatment delivery within a single breath-hold (5-10 s), efficient delivery of motion mitigation techniques, and small animal irradiation with ultra-high dose rates (FLASH).

    View details for DOI 10.1088/1361-6560/ac9d1f

    View details for PubMedID 36279860

  • Ultra-fast pencil beam scanning proton therapy for locally advanced non-small-cell lung cancers: Field delivery within a single breath-hold. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Maradia, V., van de Water, S., Meer, D., Weber, D. C., Lomax, A. J., Psoroulas, S. 2022; 174: 23-29 More

    Abstract

    The use of motion mitigation techniques such as breath-hold can reduce the dosimetric uncertainty of lung cancer proton therapy. We studied the feasibility of pencil beam scanning (PBS) proton therapy field delivery within a single breath-hold at PSI's Gantry 2.In PBS proton therapy, the delivery time for a field is determined by the beam-on time and the dead time between proton spots (the time required to change the energy and/or lateral position). We studied ways to reduce beam-on and lateral scanning time, without sacrificing dosimetric plan quality, aiming at a single field delivery time of 15 seconds at maximum. We tested this approach on 10 lung cases with varying target volumes. To reduce the beam-on time, we increased the beam current at the isocenter by developing new beam optics for PSI's PROSCAN beamline and Gantry 2. To reduce the dead time between the spots, we used spot-reduced plan optimization.We found that it is possible to achieve conventional fractionated (2 Gy(RBE)/fraction) and hypofractionated (6 Gy(RBE)/fraction) field delivery times within a single breath-hold (<15 sec) for a variety non-small-cell lung cancer cases.In summary, the combination of spot reduction and improved beam line transmission is a promising approach for the treatment of mobile tumours within clinically achievable breath-hold durations.

    View details for DOI 10.1016/j.radonc.2022.06.018

    View details for PubMedID 35788354

  • Application of a scattering foil to increase beam transmission for cyclotron based proton therapy facilities FRONTIERS IN PHYSICS Maradia, V., Meer, D., Weber, D., Lomax, A., Schippers, J., Psoroulas, S. 2022; 10 More

    View details for DOI 10.3389/fphy.2022.919787

    View details for Web of Science ID 000844346300001

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Publications (18)