An Update on the Synthesis and Applications of Bis(Naphthoquinones): An Important Class of Molecules against Infectious Diseases and other Conditions

Title:An Update on the Synthesis and Applications of Bis(Naphthoquinones): An Important Class of Molecules against Infectious Diseases and other Conditions

Volume: 21 Issue: 22

Author(s): Luana da S.M. Forezi*, Acácio S. de Souza, Carolina G.S. Lima, Amanda A. Borges, Patricia G. Ferreira, Marcela C.P. Barros, Debora O. Futuro, Fernando de C. da Silva and Vitor F. Ferreira*

Affiliation:

• Departamento de Quimica Organica, Campus do Valonguinho, Instituto de Quimica, Universidade Federal Fluminense, 24020-150, Niteroi, RJ,Brazil

• Departamento de Tecnologia Farmaceutica, Faculdade de Farmacia, Universidade Federal Fluminense, Programa de Pos-Graduacao em Ciencia Aplicada a Produtos para Saude, R. Dr. Mario Vianna, 523, Santa Rosa, 24241-002, Niteroi-RJ,Brazil

Keywords: Naphthalenedione, Quinone, Synthetic methods, Biological activities, Medicinal chemistry, Infectious diseases.

Abstract: Naphthoquinones are important molecules belonging to the general class of quinones, and many of these compounds have become drugs that are in the pharmaceutical market for the treatment of several diseases. A special subclass of compounds is that of the bis(naphthoquinones), which have two linked naphthoquinone units. In the last few years, several synthetic approaches toward such valuable compounds have been described, as well as their evaluation against numerous important biological targets. In this review, we provide a thorough discussion on the various synthetic methods reported for the synthesis of bis(naphthoquinone) analogues, also highlighting the biological activities of these substances.

Cite this article as:

da S.M. Forezi Luana *, de Souza S. Acácio , Lima G.S. Carolina , Borges A. Amanda , Ferreira G. Patricia , Barros C.P. Marcela , Futuro O. Debora , de C. da Silva Fernando and Ferreira F. Vitor *, An Update on the Synthesis and Applications of Bis(Naphthoquinones): An Important Class of Molecules against Infectious Diseases and other Conditions, Current Topics in Medicinal Chemistry 2021; 21 (22) . https://dx.doi.org/10.2174/1568026621666210727165421