Optogenetic Vision Restoration

  1. Jose-Alain Sahel4,5

+ Author Affiliations

  1. 1Degenerative Retinal Diseases, University Hospital Bonn, 53127 Bonn, Germany
  2. 2Institute of Molecular and Clinical Ophthalmology Basel, 4031 Basel, Switzerland
  3. 3Department of Ophthalmology, University of Basel, 4001 Basel, Switzerland
  4. 4Department of Ophthalmology, UPMC Vision Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
  5. 5Institut Hospitalo-Universitaire FOReSIGHT, Sorbonne Universite, Inserm, Quinze-Vingts Hopital de la Vision, 75012 Paris, France
  1. Correspondence: sahelja@upmc.edu

Abstract

Optogenetics has emerged over the past 20 years as a powerful tool to investigate the various circuits underlying numerous functions, especially in neuroscience. The ability to control by light the activity of neurons has enabled the development of therapeutic strategies aimed at restoring some level of vision in blinding retinal conditions. Promising preclinical and initial clinical data support such expectations. Numerous challenges remain to be tackled (e.g., confirmation of safety, cell and circuit specificity, patterns, intensity and mode of stimulation, rehabilitation programs) on the path toward useful vision restoration.

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  1. Published in Advance September 21, 2023, doi: 10.1101/cshperspect.a041660 Cold Spring Harb Perspect Med 14: Copyright © 2024 Cold Spring Harbor Laboratory Press; all rights reserved
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