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Effects of glucose concentration on osteogenic differentiation of type Ⅱ diabetes mellitus rat bone marrow-derived mesenchymal stromal cells on a nano-scale modified titanium
https://osaka-dent.repo.nii.ac.jp/records/158
https://osaka-dent.repo.nii.ac.jp/records/1582b28231d-153a-4f7b-bc05-bbb2493c198e
| 名前 / ファイル | ライセンス | アクション |
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学位論文 (732.6 kB)
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論文内容要旨・審査結果要旨 (226.1 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2017-04-19 | |||||
| 本文言語 | ||||||
| 言語 | eng | |||||
| タイトル | ||||||
| タイトル | Effects of glucose concentration on osteogenic differentiation of type Ⅱ diabetes mellitus rat bone marrow-derived mesenchymal stromal cells on a nano-scale modified titanium | |||||
| 著者 |
山脇, 勲
× 山脇, 勲 |
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| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bone marrow cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hyperglycemia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | osseointegration | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | titanium dioxide | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND AND OBJECTIVE: Diabetes mellitus (DM) is a common disease worldwide. Patients with DM have an increased risk of losing their teeth compared with other individuals. Dental implants are a standard of care for treating partial or full edentulism, and various implant surface treatments have recently been developed to increase dental implant stability. However, some studies have reported that DM reduces osseointegration and the success rate of dental implants. The purpose of this study was to determine the effects of high glucose levels for hard tissue formation on a nano-scale modified titanium surface. MATERIAL AND METHODS: Titanium disks were heated at 600°C for 1 h after treatment with or without 10 m NaOH solution. All disks were incubated with type II DM rat bone marrow-derived mesenchymal stromal cells before exposure to one of four concentrations of glucose (5.5, 8.0, 12.0 or 24.0 mm). The effect of different glucose concentrations on bone marrow-derived mesenchymal stromal cell osteogenesis and inflammatory cytokines on the nano-scale modified titanium surface was evaluated. RESULTS: Alkaline phosphatase activity decreased with increasing glucose concentration. In contrast, osteocalcin production and calcium deposition were significantly decreased at 8.0 mm glucose, but increased with glucose concentrations over 8.0 mm. Differences in calcium/phosphate ratio associated with the various glucose concentrations were similar to osteocalcin production and calcium deposition. Inflammatory cytokines were expressed at high glucose concentrations, but the nano-scale modified titanium surface inhibited the effect of high glucose concentrations. CONCLUSION: High glucose concentration increased hard tissue formation, but the quality of the mineralized tissue decreased. Furthermore, the nano-scale modified titanium surface increased mineralized tissue formation and anti-inflammation, but the quality of hard tissue was dependent on glucose concentration. |
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| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 34408 | |||||
| 学位授与機関名 | 大阪歯科大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-03-10 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第800号 | |||||
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Cite as
山脇, 勲, n.d., Effects of glucose concentration on osteogenic differentiation of type Ⅱ diabetes mellitus rat bone marrow-derived mesenchymal stromal cells on a nano-scale modified titanium.
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