The year is 19XX. Dr. Isaac Gilmore, a genius scientist who defected from the Black Ghost with the Zero Zero Number Cyborg he created and survived a deadly battle, once had a deep friendship with Dr. Hiro Midorikawa of Japan, who he exchanged technical knowledge about cyborgs (modified humans). While he was busy fighting the assassins sent one after another by the Black Ghost, he learned that Dr. Midorikawa had been killed by Shocker. He was a scientist who had been forced to join the evil secret society Shocker, who had valued his intelligence and technology. He could not agree with the organization's terrifying philosophy of "controlling the world with modified humans," and he attempted to escape with the cyborg he created, but the tragedy occurred after that. The pursuer of the organization that had taken his life was also a cyborg created by Midorikawa.

Gilmore managed to escape with the help of the nine cyborgs and avoided losing his life, but there is no guarantee that he will be able to survive the attacks of the Black Ghosts, which are intensifying their offensive every day. Gilmore compares Midorikawa's tragedy to his own situation and worries about the future. If there is a way to connect us to tomorrow, there is only one. Radical strengthening of the Zero Zero Number Cyborg. He combines the design concept of modified humans that Dr. Midorikawa once researched with his own cyborg design concept to plan the re-modification of the Zero Zero Number Cyborg. By further modifying the nine people who have been turned into inhuman monsters--------, are they going to walk even deeper on the path of the errant? However, it is all for the purpose of annihilating the Black Ghosts, which are the source of conflict in the world, from this world. And for the purpose of survival. No matter how rough it is, there is no other way than this. Gilmore was conflicted, but it was the nine warriors themselves who gave him a push. Only they have the power to face the crisis that is facing the world. From the day they escaped from X Island with Gilmore, the Zero Zero Numbers themselves have understood their fate better than anyone else. And they are also the ones who best understand Gilmore's heart, which is being crushed by the remorse for his sins. Gilmore and the cyborgs are not only a team, but also a family bound by a bond.

Shocker was annihilated by Dr. Midorikawa's masterpiece, the modified human "KAMEN RIDER", but the root of evil was not. Decepticons, the GOD Organization, Geddon, the Garanda Empire, Black Satan, the Delza Corps, Badan, Neo Shocker, the Dogma Kingdom, Jin Dogma. New evil organizations were destroyed and new KAMEN RIDER were born to fight them. Gilmore obtained the technical information of Kamen Rider through engineer Tobei Tachibana, who was the foster father of KAMEN RIDER, for the next 10 years. Then, in preparation for the coming battle, Gilmore started to develop the strongest cyborg by feeding back KAMEN RIDER Rider technology to the Zero Zero Number Cyborg. He used himself as a test subject and took on the form of a cyborg.