Comments for Fight Aging!

Comment on Is Most of the Detected Cellular Senescence in Tissue Actually Senescent Immune Cells? by jimofoz

jimofoz — Sun, 15 Dec 2024 00:18:23 +0000

All B cells have already been cleared in humans temporarily using CAR T cells that target them, and this seems to have cured Lupus (B cells producing auto antibodies) in 5 people.

It would be interesting to see the effects of the temporary removal of B and T cells in a mouse model. I don't know if shorter lived immune cells such as Neutrophils become long lived senescent cells.

Comment on Removing the Pressure of Impending Death by Lord BW

Lord BW — Sat, 14 Dec 2024 20:38:33 +0000

With each day closer to the new year, this horrifying "what have you accomplished this year?" voice grows louder, regardless of what one has accomplished They say "Your body will go through changes" - indeed, and none of those changes are positive.

Comment on Is Most of the Detected Cellular Senescence in Tissue Actually Senescent Immune Cells? by JLH

JLH — Fri, 13 Dec 2024 23:50:04 +0000

Senescence of the immune system is emerging as the most important variety of all senescence.

eg senescence of the autonomic nervous system coming into focus as the principal cause of hypertension - ie essential hypertension- 80% of all hypertension.

Comment on Better Understanding Why the Liver is a Highly Regenerative Organ by Elizabeth Thorne

Elizabeth Thorne — Wed, 11 Dec 2024 01:06:04 +0000

I agree with pretty much everything said, but there's a tone here that's implying that scarring is the end of the line. There is solid evidence for things like the bright streak of a recanalized hepatic artery on the ultrasound starting to break up and return to its normal aspect in cases of recovery without transplant. That is supported by histological examination of biopsies that show new growth breaking up scarred tissue. BUT...that's only been documented in cases of viral liver disease, not with Legere's cirrhosis (alcohol etiology). BUT...there are definitely cases that seem to fit that, and looking into the details, they're pretty much universally regarded as misdiagnoses, so prevalent is the belief that regeneration is impossible in those cases. I think this needs to be looked at in a more systematic controlled way. I think that there are routine violations of the model but by reclassifying them the discrepancy disappears. For eons we accepted that neural tissue does not regenerate, but now we know that if it gets cleared away there is a possibility of regeneration. That would mean the million dollar question is about the factors that encourage that pushing through scar tissue with new growth and why it's so much more likely in cases where the liver has not been damaged at a purely chemical contact level, like acetone, ether, chloroform, toluene, benzene, etc. compared to other etiologies. Which I mention because, as a statistician that has to look at control population variables vis a vis an experimental group, you really can't discriminate from liver disease caused by being vulnerable to it and drinking too much compared to not being vulnerable to it, making your own moonshine, and inadvertently drinking the heads on a regular basis. It presents the same. So, viral damage and chemical damage differentially affect whatever mechanism is driving regeneration in viral liver disease. But if it does happen and is just dismissed as an incorrect initial diagnosis, we all could really be missing a trick here. There is plenty of evidence that it does happen. Call me a philosophy student that had to get a real job, but I'm thinking we might need a paradigm change here in the way liver disease is conceptualized. That's not saying "everybody's wrong". The ancients followed the planets were intimately familiar with their movements, so were not ignorant of their "behavior", yet didn't even know they revolved around the sun. Point being, you can study a phenomenon and be convincingly familiar with it, and still not really grasp what is happening at all. I really think the liver and the immune system are the final frontiers. Medicine will advance so much if we can just bring those two areas in the fold, imho. OMGA- we know more about the brain than the liver and immune system! And we don't know squat about that. The importance of the gut biome could be added to that list, I guess. So, keep debating, throw out all kinds of contrary evidence, dispute loudly- that's how paradigms change. I'm more optimistic than Thomas Kuhn (who coined the term/concept). He thought they only changed when their proponents died. Quite possibly, but I'd like to think would could do better than than...occasionally?

Comment on Olympic Champions Exhibit Slowed Epigenetic Aging versus Other Athletes by nicholas

nicholas — Tue, 10 Dec 2024 02:20:40 +0000

Slower aging in Olympic athletes show only correlation [not causation]

Olympic athletes may have better nutrition, better inherited genome, regular exercise after retirement - all of these can correlate with slowed epigenetic aging

Comment on Preventing Enlargement of the Nucleolus Slows Aging in Yeast Cells by JLH

JLH — Sat, 07 Dec 2024 13:30:44 +0000

There is no lipid bilayer between the nucleolus and the remainder of the nucleus.
Nucleolar integrity is maintained by phase differentiation (think lava lamps). There is also an insoluble protein filament complex which is quite dense.

Sirtuins are involved eg a report of 2007:
https://portlandpress.com/biochemj/article/404/1/1/41874/Sirtuins-in-mammals-insights-into-their-biological

Sirtuin 7 is the only sirtuin located in the nucleolus, is involved in stress response and ribosome biogenesis :
https://www.mdpi.com/1422-0067/24/1/728

and
https://pubmed.ncbi.nlm.nih.gov/34573343/

Sirtuin 7 involved there somewhere.

Comment on Clonal Hematopoiesis of Indeterminate Potential Increases the Risk of Stroke by Reason

Reason — Thu, 05 Dec 2024 23:46:53 +0000

In reply to Kev. @Kev: Yes, still my opinion. The technology to make good use of them will also be the technology that makes them kind of pointless.

Comment on Clonal Hematopoiesis of Indeterminate Potential Increases the Risk of Stroke by Kev

Kev — Thu, 05 Dec 2024 21:53:36 +0000

Just curious, Reason, is your opinion still that banking/freezing your own stem cells at a younger age for potential use in future therapies is a waste of money?

Comment on A Signature of α-synuclein in Neural Exosomes from a Blood Samples by Karl Pfleger

Karl Pfleger — Mon, 02 Dec 2024 22:28:28 +0000

No, the criticism of Blue Zones is overdone in the media recently. 1 guy with a preprint has triggered way to many articles that themselves rest of shaky foundations.
See https://x.com/KarlPfleger/status/1837535246256165250

Comment on Critiquing the Blue Zones by Jan Omasta

Jan Omasta — Mon, 02 Dec 2024 20:51:47 +0000

Blue zones do not have to be the size of countries, but tens of kilometers. In our country, there is an area around the village of Scharatice, where the environment is very clean, no industry. Under the clay layer is a bedrock of dolomite and gypsum, which enriches the well water with a high content of MgSO4. People here live to be 90 to 95 years old. This is also due to the fact that it is a rich region, where a lot of meat is consumed, geese, ducks, turkeys, quails, pheasants, hares, rabbits, chickens and pork bacon.