Review

Present and future of fecal microbiome transplantation in cirrhosis

Tafader, Asiya; Bajaj, Jasmohan S

Author Information

Virginia Commonwealth University and Richmond VA Medical Center, Richmond, Virginia

Abbreviations: ACLF, acute on chronic liver failure; AH, alcohol-associated hepatitis; ALD, alcohol related liver disease; AUD, alcohol use disorder; CDR, cirrhosis-dysbiosis ratio; FMT, fecal microbiota transplantation; HE, hepatic encephalopathy; ICU, intensive care unit; MASLD, metabolic dysfunction-associated steatotic liver disease; MELD, Model for End-Stage Liver Disease; NACSELD, North American Consortium for the Study of End-Stage Liver Disease; PAMPS, pathogen-associated molecular pattern molecules; rCDI, recurrent Clostridioides difficile infection; RCT, randomized controlled trial; SBP, spontaneous bacterial peritonitis; SCFA, short-chain fatty acids.

Correspondence Jasmohan S Bajaj, Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, 1201 Broad Rock Boulevard, Richmond Virginia 23249. Email: jasmohan.bajaj@vcuhealth.org

Liver Transplantation ():10.1097/LVT.0000000000000542, November 27, 2024. | DOI: 10.1097/LVT.0000000000000542
  • Buy
  • PAP
  • Infographic
  • ACCEPTED MS

Abstract

Over the last few decades, there have been tremendous advances in our understanding of the role of the gut microbiome in cirrhosis and the clinical sequelae that follows. Progressive dysbiosis and immune dysregulation occurs in patients with cirrhosis. In fact, alterations in the gut microbiome occur long before a diagnosis of cirrhosis is made. Understandably, our attention has recently been diverted towards potential modulators of the gut microbiome and the gut-liver axis as targets for treatment. The goal of this review is to highlight the utility of manipulating the gut microbiome with a focus on fecal microbiome transplantation (FMT) in patients with cirrhosis. In addition, we will provide an overview of disease-specific microbial alterations and the resultant impact this has on cirrhosis-related complications.

Abstract
Export
Copyright © 2024 American Association for the Study of Liver Diseases.

Full Text Access for Subscribers:

AASLD members log in here
AASLD members log in here
AASLD members log in here

Not a Subscriber?

Buy
Request Permissions

You can read the full text of this article if you:

Access through Ovid