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Treading on the Footsteps of Respiratory Virology Giants

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Treading on the Footsteps of Respiratory Virology Giants

An act of remembrance

Tom Jefferson
and
Carl Heneghan
Nov 08, 2024
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Treading on the Footsteps of Respiratory Virology Giants

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Over the course of our nearly 800 posts, we have tried to give credit where credit is due to those who dedicated their lives to investigating respiratory agents. We have done so for several reasons.

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First, it is their due as an act of remembrance and respect for what they achieved, which is topical this week.

Second, we were struck by the crass ignorance demonstrated by some of our “colleagues”, the media, governments, and all those who pretended that influenza was the only agent and partially still do by introducing the concept of the big “three”: RSV, SARS-CoV-2 and influenza  

Connecting the Dots

Tom Jefferson and Carl Heneghan
·
Oct 15

We have received many comments in the last few days, all of them adding something to the great puzzle of where all our money goes. We arbitrarily selected two comments on different posts that we think will give us some ideas of the cash's direction of travel and its value to the taxpayer.

Read full story

and using the f-word “flu” to confuse and justify fleecing the public.

Why we shouldn't use the "F Word": the long read

Tom Jefferson and Carl Heneghan
·
January 14, 2023

The colloquial “Flu,” the “F Word”, is synonymous with an acute respiratory infection, sometimes merging and overlapping with influenza. It is an ill-defined and sloppy concept which creates confusion about the burden of respiratory illness in the world around us.

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Of course, this distortion of microbiology and epidemiology has nothing to do with the fact that licensed products are only available for these three agents.

Never mind good old rhinoviruses, which are continuously circulating, and their numerous groups of colleagues, including adenovirus, parainfluenza, metapneumovirus, and so on, that accompany its general circulation. They count for nothing. There's no money in them with no antivirals or vaccines to peddle.

Third, only when academics and public health bodies stop distorting messages will we make research programmes that matter and try to understand the interplay between agents. We could even find something that works in serious cases and effective interventions that prevent transmission. Of course, this is also premised on proper investigative work on the ecology and transmission of these agents, using molecular methods at our disposal.

Our esteemed predecessors did that with the means at their disposal. Their professionalism and serious curiosity led them to develop new methods for identifying agents and culturing them, starting with influenza.

So we intended to make Smith, Laidlaw, Andrewes, Tyrrel, Bynoe, Almeida, Shope, Chanok, Dochez, Gwaltney, Handley, D’Alessio, Dick, Hope-Simpson, Allen, Callow, Reed, and so many others immortal, their work cited by us over and over again. Who? You may ask. Fair enough: for example, when Tyrrel and Bynoe first isolated coronas, June Almeida gave them their name. Got it?

Apart from citing them in Trust the Evidence and in the books we are working on, there is one more strand that we can explore. In the Riddles series, we reported on the work of the MRC Common Cold Unit.

The SARS-CoV-2 transmission riddle - Part 6

Tom Jefferson and Carl Heneghan
·
September 28, 2022

In the first five parts of the Riddle series, we have discussed how poor quality and superficial science has led to research waste and misled the globe as to the number of active covid cases, the incidence of hospital-acquired covid and the number of deaths directly attributable to SARS-CoV-2, We have also remarked on the apparent unwillingness of decis…

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The University of Wisconsin

The SARS-CoV-2 transmission riddle - Part 7

Carl Heneghan and Tom Jefferson
·
October 5, 2022

As we have seen in Riddle 6, respiratory viruses have been the source of investigation for at least a century. Shope, the discoverer of swine influenza and Smith, Laidlaw and Andrewes, discoverers of the human variety, could not visualise the agent, although they could filter it from human washouts. They knew the agent was there, but visualisation had t…

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The University of Virginia

The SARS-CoV-2 transmission riddle - Part 8

Tom Jefferson and Carl Heneghan
·
October 12, 2022

Head of the University of Virginia (UVA) group, Dr Jack Gwaltney Jr’s research on acute respiratory infections was prodigious, meticulous in its methods and manifestly helped our understanding of SARs-COV-2. Although it is difficult to determine the most important publications, we selected four that inform the transmission riddle.

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Because of our limited means, we intend to concentrate on making the MRC Common Cold Unit’s 1,006 studies publicly available and some personal correspondence between Tom and the late Dr David Tyrrel as background. 

In 2014, Tom sent Tyrrell’s personal filing cabinet to the Welcome Foundation so that anyone researching these giants could get a good background “fix” on how they collaborated.  They collaborated across the pond without censorship, wokery or “I was there first” syndrome. 

We’re starting by unearthing several documents that haven’t yet seen the light of day.  Wish us luck in our endeavours.

This post was written by two old geezers who believe in giving merit where it’s due.

Trust the Evidence is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.











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Treading on the Footsteps of Respiratory Virology Giants

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Discussion about this post

James Jones
Nov 9

thanks for this; marvellous and very constructive work; well done

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The Lockdown files message is clear: we must never again suppress democracy by giving power to power-hungry people.
Read the piece on the Sunday Express and Sir Graham Brady MP’s comment
Mar 5, 2023 • 
Carl Heneghan
 and 
Tom Jefferson
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The Lockdown files message is clear: we must never again suppress democracy by giving power to power-hungry people.

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HRH The Princess of Wales
We offer our support.
Mar 24 • 
Tom Jefferson
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HRH The Princess of Wales

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Connecting yet more Dots
Exaggerating the Influenza Threat - Reflections of a long-time Cochrane reviewer.
Oct 24 • 
Tom Jefferson
208
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Connecting yet more Dots

trusttheevidence.substack.com
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