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  • RESEARCH BRIEFINGS

Cage-like complexes that protect folding proteins visualized in cells

The bacterial chaperonin complex — consisting of the proteins GroEL and GroES — assists the folding of newly synthesized proteins by transiently encapsulating them in a nanometre-scale cage. Visualizing this process using cryo-electron tomography in the intact cellular environment provides insights into the chaperonin reaction cycle in vivo.

This is a summary of: Wagner, J. et al. Visualizing chaperonin function in situ by cryo-electron tomography. Nature 633, 459–464 (2024).

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doi: https://doi.org/10.1038/d41586-024-02926-0

‘Expert opinion’ and the figure are published under a CC BY 4.0 licence.

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