Volume 134, Issue 7 p. 3310-3315

Original Report

An Update on the Epidemiology and Clinicodemographic Features of Meniere's Disease

Emma De Ravin BS,

Emma De Ravin BS

Department of Otolaryngology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Alexandra E. Quimby MD, MPH,

Corresponding Author

Alexandra E. Quimby MD, MPH

alexandra.quimby@pennmedicine.upenn.edu

orcid.org/0000-0003-4864-8917

Department of Otolaryngology and Communication, SUNY Upstate Medical University, Syracuse, New York, USA

Send correspondence to Alexandra E. Quimby, Department of Otolaryngology and Communication Sciences SUNY Upstate Medical University, 750 E Adams St., Syracuse, NY 13210, USA. Email: alexandra.quimby@pennmedicine.upenn.edu; Michael J. Ruckenstein, Department of Otorhinolaryngology – Head and Neck Surgery 3400 Spruce Street – 5 Silverstein Pavilion, Philadelphia, PA 19104, USA. Email: michael.ruckenstein@pennmedicine.upenn.edu

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Michael Bartellas MD, MSc,

Michael Bartellas MD, MSc

orcid.org/0000-0003-2001-1404

Department of Otolarynology – Head & Neck Surgery, University of Ottawa, Ottawa, Ontario, USA

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Sydnie Swanson BS,

Sydnie Swanson BS

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Tiffany P. Hwa MD,

Tiffany P. Hwa MD

orcid.org/0000-0002-7274-9366

Department of Otorhinolarynoglogy – Head & Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Douglas C. Bigelow MD,

Douglas C. Bigelow MD

Department of Otorhinolarynoglogy – Head & Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Jason A. Brant MD,

Jason A. Brant MD

orcid.org/0000-0002-3492-0679

Department of Otorhinolarynoglogy – Head & Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA

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Michael J. Ruckenstein MD, MSc,

Corresponding Author

Michael J. Ruckenstein MD, MSc

michael.ruckenstein@pennmedicine.upenn.edu

Department of Otorhinolarynoglogy – Head & Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Emma De Ravin BS,

Emma De Ravin BS

Department of Otolaryngology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Alexandra E. Quimby MD, MPH,

Corresponding Author

Alexandra E. Quimby MD, MPH

alexandra.quimby@pennmedicine.upenn.edu

orcid.org/0000-0003-4864-8917

Department of Otolaryngology and Communication, SUNY Upstate Medical University, Syracuse, New York, USA

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Michael Bartellas MD, MSc,

Michael Bartellas MD, MSc

orcid.org/0000-0003-2001-1404

Department of Otolarynology – Head & Neck Surgery, University of Ottawa, Ottawa, Ontario, USA

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Sydnie Swanson BS,

Sydnie Swanson BS

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Tiffany P. Hwa MD,

Tiffany P. Hwa MD

orcid.org/0000-0002-7274-9366

Department of Otorhinolarynoglogy – Head & Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Douglas C. Bigelow MD,

Douglas C. Bigelow MD

Department of Otorhinolarynoglogy – Head & Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Jason A. Brant MD,

Jason A. Brant MD

orcid.org/0000-0002-3492-0679

Department of Otorhinolarynoglogy – Head & Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA

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Michael J. Ruckenstein MD, MSc,

Corresponding Author

Michael J. Ruckenstein MD, MSc

michael.ruckenstein@pennmedicine.upenn.edu

Department of Otorhinolarynoglogy – Head & Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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First published: 18 January 2024

https://doi.org/10.1002/lary.31282

Editor's Note: This Manuscript was accepted for publication on December 22, 2023.

Dr. Jason Brant's contribution to this work was supported in part by the Department of Veterans Affairs (BLR&D Career Development Award #IK2-BX004910).

The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objective

To characterize the estimated prevalence and clinicodemographic features of Ménière's disease (MD) using current diagnostic criteria.

Methods

A cross-sectional study was undertaken at our tertiary academic referral center. All patients seen in Otolaryngology clinic with ICD-10 diagnoses of MD, from January 1, 2013 to July 31, 2022 were identified. Chart review was undertaken to determine the estimated prevalence of MD meeting AAO-HNS diagnostic criteria. Clinicodemographic features were evaluated against a comparator group without MD seen in our health system.

Results

Of 806 ICD-10 diagnoses of MD, we identified 480 MD cases meeting diagnostic criteria (168 definite). Mean age at presentation for MD cases was 49 years. Forty-seven percent of cases were male. A significantly higher proportion of MD cases than comparators were white (76% vs. 66%, p < 0.001). Mean time since MD symptom onset was 6.7 years, with a mean attack duration of 4.6 h; 7.5% of MD cases reported a positive family history, and 7% had bilateral disease. The odds of reporting migraine were significantly greater among MD patients than comparators (OR 1.74 [1.26–2.42]); the odds of having autoimmune conditions were lower (OR 0.45 [0.28–0.74]); and the odds of reporting allergies were no different (OR 0.96 [0.74–1.25]) versus comparator patients after controlling for demographic characteristics.

Conclusions

Among MD diagnoses, there is a low estimated prevalence of MD meeting diagnostic criteria, and an even lower prevalence of definite MD. Compared to a comparator group of patients seen for any disorder, patients with MD are more likely to be white, male, and have a history of migraine.

Level of Evidence

4 Laryngoscope, 134:3310–3315, 2024

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Volume134, Issue7

July 2024

Pages 3310-3315

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Research funding

Department of Veterans Affairs. Grant Number: #IK2-BX004910

Keywords

Publication History

Issue Online:17 June 2024
Version of Record online:18 January 2024
Manuscript accepted:22 December 2023
Manuscript revised:27 November 2023
Manuscript received:07 August 2023

An Update on the Epidemiology and Clinicodemographic Features of Meniere's Disease

References

Information

Abstract

Objective

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

References

Information

Metrics

Details

Research funding

Keywords

Publication History

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An Update on the Epidemiology and Clinicodemographic Features of Meniere's Disease

References

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Information

Abstract

Objective

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

References

Related

Information

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