How Alchemy Paved the Way for Chemistry

By: Nathan Chandler  | 
All those experiments trying to make gold from lead helped create the scientific method. aluxum/Getty Images

When you think of "alchemy" do you imagine wizards brewing up concoctions of bat wings and blood? Contemporary historians would have you reconsider. Some researchers see alchemy not as fodder for "Harry Potter" stories and Wiccan ceremonies, but as the forerunner of modern science, particularly chemistry. Some of these people might've been among the best scientific minds of their eras, blazing trails that led to scientific insights all over the world.

Alchemy was, at its core, a way for inquisitive minds to explore the way the world worked, attempting to decipher nature's functions and leverage them for various purposes. To achieve those ends, alchemists theorized, it was necessary to purify the spirit, body, and mind.

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Turning Lead Into Gold

People who practiced alchemy were searching for ways to (a) produce elixirs which would hopefully cure all kinds of diseases, and (b) turn base metals (like lead) into precious ones (like gold) via a yet-to-be-found substance called the philosopher's stone. "The Chinese were particularly interested in the first [search], the western Europeans in the second," emails Peter Maxwell-Stuart, who teaches history at the University of St. Andrews in Scotland.

From the first centuries C.E., China and India were practicing a form of alchemy, Maxwell-Stuart says. Europeans widely practiced alchemy during the Middle Ages (roughly 1000 C.E. until 1500) and even into the 18th century. "Its popularity waned during the 19th [century], but it survived even then and was still being practiced in the 20th century, too," he adds.

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Thanks in part to beliefs that ultimately went back to Aristotle and the Greek philosophers, alchemists thought that nature was always striving to perfect itself. And since gold was the "perfect metal," in part because it doesn't rust or tarnish, it was regarded as the end-all, be-all of metals. The thinking was that "all other metals would eventually turn into gold by natural processes over a very long period of time," says Maxwell-Stuart.

So, the alchemist was seeking to speed up this natural process in the laboratory. "Given the basic assumptions of their belief systems, the alchemist's endeavors were entirely rational," he says. "Theoretically, too, alchemical experimentation might give an insight into God's intentions in creating the universe the way he did."

With their boiling cauldrons and intricate crucibles, alchemists (who were predominately but not exclusively men) exhibited a willingness to experiment, a trial-and-error mentality that explored multiple disciplines in hopes of illuminating nature's intricacies through honest scholarship and research. Alchemists tinkered with chemical process, like dyes and perfumes, and of course, also found ways to change the properties of various alloys.

One didn't attend "Alchemy University" to learn these skills. Instead, the knowledge of master alchemists was transferred to apprentices under a shroud of secrecy; because that knowledge was so powerful, alchemists wrote in obscure symbols, codes and metaphors to protect their ideas and insights.

Despite all the mystery, not all the experiments were bogus. Lawrence Principe, a chemist and science historian at Johns Hopkins University, decided to recreate a medieval alchemy experiment, one that he hoped would conjure a "philosopher's tree" made from a tiny bit of gold. (The philosopher's tree was a precursor to the philospher's stone.) He blended gold and mercury into a flask, which he then placed under warm sand in his lab. Days later, he was astonished to see that the recipe had in fact worked, generating a golden tree-like structure that would've undoubtedly drawn even more awe centuries ago.

These kinds of wonders may not have been possible if not for the work of countless alchemists of yore, who often used techniques like sublimation and distillation that would be familiar to any modern chemist.

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From Alchemy to Chemistry

Swiss physician Paracelsus was one famous alchemist from the 16th century. Part prophet, part metallurgist, part doctor, he became known as the world's first toxicologist, because he realized the correlation between dosage and toxicity — that poisons in small doses might be helpful to humans, while larger doses could be fatal. In his work, Paracelsus gave rise to the concept of making clinical medical diagnoses and then treating conditions with specific medicines.

In the 17th century, British inventor, philosopher and scientist Robert Boyle wished to find the secret of the philosopher's stone, which in the alchemic tradition was the most powerful force in nature. That power, he thought, was a key to the secrets of the universe. Although Boyle is best-known today for pioneering the scientific method and for the law named after him (Boyle's Law says that the volume of a gas varies inversely with pressure), he was enamored with alchemy all his life.

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At the same time Boyle was hard at work, Isaac Newton, the genius who gave shape to the laws of gravity and optics, was actively involved in alchemy. For decades, he pursued alchemic secrets that he felt were perhaps even more fundamental than gravity: He hoped that in teasing out the chemical and mineral makeup of the world, scientists could perhaps find the one true essence of nature, thereby wielding immense power.

With its roots divided between philosophical, religious, mystical and scientific pursuits, alchemy eventually ran into the buzz saw of rational thinking that developed during the Age of Enlightenment. Its secretive tendencies drew suspicions from the government and the church, and its associations with the occult didn't help, either.

As such, alchemy faded into obscurity, leaving behind a reputation colored by charlatanism and quackery. It's no wonder that ancient peoples first gawped at the perceived power of alchemists, and later, as more refined scientific methods took hold, began to mock them.

But with their legitimate chemical experimentations and applications, alchemists had already made their mark, paving the way for modern chemistry.

"Experimentation almost inevitably resulted in the discovery of various substances hitherto either unknown or not understood — phosphorus is an obvious example — and so that aspect of alchemy leads into modern chemistry," says Maxwell-Stuart.

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Frequently Answered Questions

What alchemical means?
The definition of alchemical is relating to the science of chemistry, or relating to the transformation of matter.

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How Isaac Newton Worked

By: Jacob Silverman

Without these three -- (L to R) Isaac Newton, Johannes Kepler and Galileo on the Astronomers Monument at the Griffith Observatory in Los Angeles -- where would science be?
Stephen Dunn/­Getty Images

­Sir Isaac Newton is considered one of history's great polymaths, having contributed to the fields of mathematics, physics, astronomy, theology, chemistry and biblical history. In some ways, he was a stereotypical genius -- deeply absorbed in his work, sometimes forgetting to eat or teach his classes, disheveled in appearance, hardly sleeping. But Newton was also highly competitive, temperamental and sometimes ruthless. And despite the popular image of him as rationalism personified, Newton was also highly religious and deeply immersed in the studies of myth and alchemy.

Born in 1643, Newton came from a family of moderately successful farmers, although his father, also named Isaac, was illiterate and died before the younger Isaac was born. Consequently, the future scientist had a difficult childhood. Unappreciated by his stepfather, Newton was forced to live with his grandmother until his stepfather died, when he was reunited with his mother.

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­Newton never married and had few close friends in a relatively long life. (He died at age 84.) He suffered from his intense devotion to his studies, experiencing more than one nervous breakdown. It took him several years to recover from his first breakdown in 1675, which was followed by the subsequent shock of his mother's death. However, he did inherit a sizable estate from her, allowing him financial independence.

The legendary scientist held many notable positions in his lifetime, among them:

  • 1667 -- Fellow of Trinity College, Cambridge
  • 1669 -- Lucasian Professor of Mathematics at Cambridge (a position now held by Stephen Hawking)
  • 1689 -- Member of Parliament representing Cambridge
  • 1699 -- Master of the Mint
  • 1701 to 1702 -- Member of Parliament for the second time
  • 1703 -- President of the Royal Society of London, the United Kingdom's national academy of science
  • 1705 -- Knighted

His professional life, though, was not without challenges, and he had many critics and competitors throughout his career. Yet despite the controversy he sometimes engendered, by the time he died, Newton was a celebrated scientist and thinker throughout Europe. He died a wealthy man and had a lavish funeral ceremony at Westminster Abbey, where he's buried.

­In this article, we'll explore all sides of Isaac Newton -- from his search for the fabled philosophers' stone to his groundbreaking work on calculus and gravitation. We'll look at why he set out to ruin the reputation of one of his peers and how his work changed the very nature of scientific inquiry.

Newton as a Student and Scholar

After a mixed record as a high-school level student, Newton proved himself dreadful at farming and overseeing his family's affairs, though he may have failed intentionally so that he wouldn't have to carry that responsibility [source: The Newton Project]. His failure allowed him to continue his education. He eventually went on to study at Cambridge, paying his way through school by acting as a servant to wealthy students and starting a small loan business.

While at Cambridge, Newton paid scant attention to the required curriculum, instead following his own intellectual whims. Because of his lack of success there, the Cambridge faculty thought that he showed little promise. But Isaac Barrow, a noted scholar and mathematician, discovered Newton's talents and mentored him.

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From 1665 to 1667, Newton left Cambridge after an outbreak of the plague closed the university. Popular conception has it that he made many of his most important discoveries during one year in this period -- sometimes called his annus mirabilis, or "year of miracles." It's more likely that at least some of these major discoveries came later, over an extended period of time and with important subsequent breakthroughs and revisions of his original ideas [source: MathPages]. But the great man himself probably propagated this myth of the year of miracles. When Newton became involved in various conflicts with other scientists over claims of discoveries, it was to his advantage to claim that he had made these breakthroughs years before.

As a fellow at Cambridge's Trinity College, Newton was known as obsessively devoted to his work, rarely allowing himself any time for relaxation. His lack of sleep wore him down, but he wasn't a complete shut-in. He actively corresponded with other scientists and counted a select few among his friends.

Newton is highly regarded not only for his discoveries but also for the quality and rigor of his experiments. He was incredibly precise, took careful notes and paid close attention to evidence. He concocted theories from the information at hand and then created reasonable experiments with which to test them. He was also far ahead of his time in how he considered data, for example, by calculating averages when he had several different measurements for the same phenomenon. Believe it or not, this wasn't a common practice then. His scientific method became the standard from which future scientists would draw.

­Now that we've laid some of the groundwork for who Newton was as a person and as a scholar, let's consider some of his major accomplishments.

Newton's Discoveries and Inventions

The reflecting telescope invented by Sir Isaac Newton in 1671. By using a curved mirror to reflect and focus the light, the length of the telescope was dramatically reduced.
Hulton Archive/­Getty Images

Newton didn't attempt to publish some of his early discoveries, such as his work on the shape of orbits. Modesty and controversy made him hesitant to share his theories. His claim that all of natural philosophy -- the forebear to the natural sciences -- could be explained through mathematics was both groundbreaking and highly controversial when introduced in 1670 [source: The Newton Project]. That same idea formed the basis of his first masterwork, the Principia.

­Eventually Newton's genius came to be widely known. His three laws of motion -- inertia, acceleration, and action and reaction -- remain a cornerstone of modern physics. His law of universal gravitation laid forth the theory that all particles in the universe exerted some gravitational force. In Newton's view, gravitational force was everywhere, from an apple falling from a tree to the moon being kept in orbit by its mutual attraction with Earth. While imperfect -- his law was later altered significantly by Einstein's theory of relativity -- Newton's conception of universal gravitation dominated physics for more than two centuries.

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In his student years, Newton performed experiments in optics examining the nature of light. He found that normal, or "white," light is actually made up of a spectrum of colors. He used prisms to break apart white light into a rainbow of colors and recombine the disparate colors into white light. Despite his breakthroughs in optics, Newton didn't publish his conclusions until 1704, in "Opticks," which was considered his second great scientific treatise [source: The Newton Project].

Isaac Barrow, Newton's mentor, was instrumental in presenting one of Newton's major inventions to the scientific community. The refracting telescope commonly used during the period often couldn't produce clearly focused images. Newton replaced the mirrors of the refracting telescope with lenses. His new telescope, the reflecting telescope, was one-twelfth the size of conventional refracting telescopes and had more powerful magnification powers. Barrow's presentation of it to the Royal Academy earned Newton membership.

­Newton also created calculus as a response to the insufficiencies in mathematics of the time. Originally called the fluxions or the "method of series and fluxions," calculus provided methods for solving complex problems about orbits, curves and other issues that classical geometry couldn't solve [source: The Newton Project]. Calculus is particularly suited to these challenges because it produces information about things that are continually changing -- like the speed of a falling object. In calculus, Newton laid the basic framework for understanding these problems and for making the calculations described by his laws of motion and gravitation.

Newton and Alchemy

The alchemy symbol for fire
Stephanie Dalton Cowan/­Getty Images

­Newton wasn't always good at accepting criticism, and intense clashes with the British physicist Robert Hooke and others spurred him to retreat from the scientific community for much of the 1670s. These traumas, combined with the death of his mother, caused Newton to isolate himself during this period. He published little and devoted himself to religious and alchemical studies.

Alchemy was a popular subject back then. In some ways, it can be considered an early form of chemistry. While today there is much stigma against alchemy, many of Newton's contemporaries were involved in it. Practitioners of alchemy, Newton included, thought that common metals could be turned into gold. Other alchemists held similar mystical ideas, such as believing that immortality-granting elixirs could be created. But alchemy was a wide-ranging discipline, encompassing more legitimate practices, like creating paints.

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To Newton, alchemy represented a riddle, steeped in ancient Greek myths and the work of past alchemists, whom he studied closely. Deciphering this riddle could allow him to control nature. He even believed that he was potentially part of a line of great men chosen to receive hidden, ancient wisdom [source: NOVA]. Newton so devoted himself to alchemy and its mystical practices that he created a special name for himself: Jehovah Sanctus Unus. It translates, from the Latin, to Jehovah, the Holy One [source: NOVA].

Like many others before him, Newton attempted to produce the mythical philosophers' stone [source: NOVA]. The stone was thought to be a substance that could turn metal into gold, cure diseases and perform other powerful effects.

Newton didn't publish his work on alchemy, in part because he was rather secretive about it. He thought that he made progress on some of alchemy's great challenges, like the philosophers' stone, so he wanted to keep his work to himself. Alchemy was also illegal until just before Newton's lifetime, and by the end of his life, with his reputation well-established and the Enlightenment in full swing, there was great stigma against the practice, particularly for someone as celebrated as Newton.

Some of Newton's texts on alchemy may have been destroyed.­ Others are so full of riddles, code names and vague details as to be difficult to decipher. But many of his texts are available for study and provide an interesting perspective of a complicated, mystically inclined, highly ambitious genius, who wanted to understand the universe in any way he could.

The Principia Mathematica

A very excited librarian holds a copy of one of the most important scientific works ever written, the Principia.
Daniel Berehulak/­Getty Images

­Early in his career, Newton was often reluctant to publish his work, despite encouragement from some of the preeminent minds of his day. His own modesty (which didn't last f­orever), combined with some of the criticism he received about his early discoveries, caused him to keep some ideas to himself. But eventually, with the support of Barrow and others, Newton began to write and publish widely.

No publication of Newton's is more important than "Principia Mathematica." In this document, the full name of which is "Philosophiae Naturalis Principia Mathematica," Newton defined his three laws of motion. He described how elliptical orbits work and how bodies in motion exert force upon on another. The work also contained his findings about fluids and mechanics.

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Begun during his intensely productive years at Cambridge in the mid-1660s, the Principia, as it's often called, was published in 1687. It represents a transformational work, one of the world's most important scientific treatises. It quickly vaulted him to the elite ranks of scientific theorists.

The Principia provided a physical and mathematical basis for how basic elements of the universe work and how celestial bodies move and interact with each other. No longer were vague stories or conjectures enough to explain the world. From then on, a scientist could not say that the sun revolved around the Earth or make some other declaration without using the mathematical processes (namely, calculus) and rigorous scientific method laid out by Newton.

The work did involve some contributions from Newton's contemporaries and forebears. For example, German scientist Johannes Kepler found that planets had elliptical orbits. He also made other observations about the radii of orbits and how long revolutions took. But he couldn't come up with a mathematical justification of why and how, which is what Newton accomplished, conceiving a universal theory of gravitation that could apply to all celestial bodies, from the smallest moon to the largest star.

­Despite its revolutionary content, scientists found the Principia very difficult to understand. Many of the era's scholars couldn't decipher it, including, for a time, Leibniz and Huygens­, two of Newton's great contemporaries. This gap in understanding existed in part because there were few people in the world studying mathematics at such a high level. And the work seemed very theoretical, difficult to apply in the real world.

The Genius in Private: Newton and Arianism

Circa 320 A.D., Lybian theologian Arius, the founder of Arianism, the theological idea that says that Jesus Christ isn't co-equal or co-eternal with God.
Hulton Archive/­Getty Images

­While studying in university, Newton found himself drawn to religion and began a lifelong study of religious history and theology. At that time, he wrote a list of all the sins he had committed, which seemed minor by most standards (such as breaking the Sabbath by baking pies). As a scientist, his religiosity informed his research and motivated his belief that rational forces dominated the world. Newton thought that the universe must abide by calculable rules and laws because a rational, logical force -- God -- had created them.

Newton also had some eccentric theological opinions that came to be shared by the devoted following that developed around him after the publication of the Principia. He thought, for example, that his scientific discoveries were actually recovered "ancient wisdom" from pre-Christian civilizations. In his view, these pre-Christian civilizations understood the laws of the universe, but they encoded these ideas in myths, monuments and religious sites.

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Newton also believed that mainstream Roman Catholicism, Anglicanism and Calvinism were heretical and corrupt. He thought that the Holy Trinity, one of the main doctrines of orthodox Christianity, wasn't in line with the beginnings of early Christianity. He was influenced in this regard by an obscure theological notion called Arianism.

Arianism states that Jesus, while created by God, was not divine. Believers in Arianism, Newton included, feel that the Holy Trinity actually represents a heresy that the Council of Nicaea, in the 4th century, mistakenly made part of Christian dogma. Critics of Arianism have said that it encourages polytheism, since it casts Jesus as less than divine but still deserving of worship [source: Britannica].

The Council of Nicaea attempted to do away with Arianism by proclaiming Jesus' divinity and the sanctity of the Holy Trinity. It didn't survive much beyond the 7th century, except in altered form and in the occasional adherent, such as Newton.

Despite his thorough research into theological matters, Newton did not publicize much of his religious inquiries. For him, it was largely a personal effort to get back to the true foundations of his religion [source: Snobelen]. His beliefs were also highly controversial at the time, only a few decades after heretics in England were burned at the stake. So Newton mostly kept his beliefs to himself, for fear of becoming an outcast or losing his university position.

­After he died, Newton's relatives concealed most of his writings on religion and alchemy because they could have severely damaged his reputation. Most of these papers only became available to scholars when they were released on microfilm in 1991.

Newton Myths: Self-made and Otherwise

A notebook belonging to Isaac Newton describes an experiment he conducted on himself that involved placing a sharp instrument between his eye and the bone in order to induce the sensation of color.
­AP Photo/Mary Altaffer

­Although he was one of history's great geniuses, Newton certainly capitalized on the work of his predecessors. For example, Galileo had already figured out aspects of two of the basic laws of motion [source: Einstein]. He knew that an object would continue moving unless some outside force acted upon it. He also discovered that a free-falling object's velocity increases over time. But Newton added to these ideas by figuring out that the key to all of these phenomena is mass. Each mass, he determined, influences each other, based on the theory of universal gravitation. Consequently, even the smallest atoms exert gravitational force on one another.

Newton, however, may have wanted his contemporaries to believe that his genius was his alone. Take the well-known apple story. This popular tale finds Newton lying in a garden, considering how the moon orbits the Earth. Suddenly, he sees an apple fall to the ground and has an epiphany -- the same force that caused the apple to fall also kept the moon in orbit around the Earth. But many think that the story is a bit too convenient [source: NOVA]. After all, Newton didn't complete his theory of universal gravitation until 1686. Yet, he later helped to propagate the story as true [source: The Newton Project].

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Other stories have been inflated by historians or rumors. Much has been made of Newton predicting the second coming of Jesus in the year 2060, but the date was only Newton's idle speculation [source: Snobelen].

Similarly, it's often said that Newton was born the same year Galileo died, somehow implying a cosmic connection between the two. This claim is based on a mistake produced by using the old Julian calendar for Galileo's death and the modern Gregorian calendar for Newton's birth. In fact, when using the same calendar, Newton's birth and Galileo's death fall almost a year apart.

Newton's deliberate striving toward greatness took its toll on him. Newton once stared at the sun with one eye until he could hardly see anything besides reds and blues. His eyes later recovered.

­It wasn't just his eyes that were sensitive. Newton suffered two nervous breakdowns, and he subsequently gave up scientific research after the second one in 1693. Three years later, he accepted a position with the Mint. Most officers of the Mint had traditionally done little, instead enjoying the title and income that come with such positions, but Newton threw himself into the role and went after counterfeiters.

Newton's Rivals and Legacy

In his own time, Newton's ideas changed the world, and the publication of the Principia brought him into contact with most of the great minds of his age. He corresponded, debated and shared ideas with many of them.

Edmond Halley, he whom the famous comet is named after, was a vocal backer of Newton in the scientific community, but Newton also had many rivals. He had intense arguments with Robert Hooke, who accused Newton of stealing from his work. Even so, he corresponded and exchanged ideas with Hooke.

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Gottfried Leibniz, a German philosopher, mathematician and scholar of many fields, was also one of the pioneers of calculus. There was a tremendous rivalry between the two men as to who invented calculus. The two had corresponded about their work, and Newton claimed that Liebniz stole some of his calculation methods, even though Leibniz had conceived of some of the basic ideas of calculus on his own.

As old men, the two great thinkers frequently and publicly fought about their contributions to calculus. In scientific journals and letters, they rallied their supporters to their respective causes.

Newton was aggressive in trying to discredit his rival. By then well respected and quite powerful, Newton used his position as president of the Royal Society to anonymously draft a report claiming that he was the inventor of calculus. The rivalry continued until Leibniz's death.

Astronomer John Flamsteed's observations of comets contributed to some of Newton's breakthroughs about gravitation. But Flamsteed felt that Newton didn't adequately acknowledge his contributions to the Principia. He may have been justified: Newton removed all references to Flamsteed in the second edition of the Principia.

Albert Einstein revered Newton. He especially admired Newton's ability to create empirical methods that could verify the speculations of Descartes, Kepler and other thinkers, going back to the ancient Greeks. He also wrote about how Newton's innovations provided the basis for numerous subsequent discoveries: James Clerk Maxwell and Michael Faraday's work on optics and electrodynamics, electromagnetic fields, conservation of energy and thermodynamics.

It wasn't until the early 20th century and the development of quantum and theoretical physics that scientists began moving out of Newton's long shadow. Einstein's theory of general relativity dramatically departed from Newton's ideas, but they remain important and applicable to numerous aspects of science and the physical world. His legacy as the founder of the modern scientific method, as an inventor, innovator and brilliant scholar, remains assured.

­Keep reading for more information about Isaac Newton, scientific breakthroughs and other related topics.

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