Isekai Yakkyoku

Both MCs are Reborn into another world with knowledge from the future. Both improve standard of living and have to deal with nobles and religious people who want them gone. Neither are about fighting, but rather about knowledge. 

MC has incredible amounts of magical powers with zero interest in greatness, Sainthood or Godlike. They care much more for their nerdy passions of medicinal mixtures and helping alleviate others' ailments. No unlikable characters, overall wholesome and chill shows to watch. 

Kid protagonists both worked too hard in their previous life. Open a shop/pharmacy as a business. Both MC are OP characters. 

The MC reincarnates into a new body in a family that has the same profession as the MC had in his previous life. In Sekai Saikou the MC is an expert assassin and in his new life, he gets the mission to assassinate the hero. In Isekai Yakkyoku, the MC is a doctor and an expert in the medical field, and he sets it upon himself to improve medicine in this fantasy world. Both shows give me similar vibes in how they introduce the characters, and how they react upon reaching the new world, living a life as the son of an aristocrat. 

In both animes you accompany the protagonists to manage a store that is focused on helping people. 

A pharmacist is reborn in another world.  

Protagonist finds himself in a primitive world, which he strives to improve with his great knowledge of modern science. 

MCs who are within the medical field die on Earth and are reincarnated to a world that isn't as technologically advanced, they use their knowledge from their past life to help people as a doctor/pharmacist. Main difference is that Isekai Yakkyoku has magic whereas Gekai Elise doesn't, plus in GE the MC used to be from that world too and is now mending her mistakes plus revolves around romance too which IY doesn't really have. 

Both MCs die from overworking and are transported into another world in a child's body. With their knowledge from their original world. Slow but steadily enhances the technology in their new world  

In both shows a guy gets reincarnated into a fantasy world who then uses his (extensive) scientific knowledge to improve his magical skill. 

Both MCs are reincarnated as a child in the royal family, use knowledge from other world to help themselves. Both over powered.  

just like in the anime Parallel World Pharmacy, the main character heals, creates and also has divine abilities, and she is just like him very friendly and tries to help everyone in every possible way, as well as cure. 

Main characters are pharmasists, who run their own pharmacy, with help of friends 

Both Mc are white head that will bring their previous life profession to another world. both anime follow the same naming scheme by doing pun with their names.  

Ambos são ISEKAI em que contam histórias simples e leves, e que possuem ali um pouco do cotidiano dos personagens, ou seja, slice of life, mas esse aqui tem uma dose de fofura incrível!!! Na minha opinião Isekai Yakkyoku (Parallel World Pharmacy) parece ter um pouquinho mais de investimento. Inclusive a segunda temporada é feita pelo mesmo estúdio. Também segue uma história leve e mais de cotidiano de fantasia, recomendo 

Both have unique main protagonists who are unusually skilled in medicine and are set in alternative universes with medieval flair. They both also have lots of wholesome vibes. 

Has a similar baseline of a medical protagonist and a loving female assistant  

Both wholesome stories about people trying their best to heal those around them. The protagonists both have abilities beyond their own complete understanding making the struggle to be their best healing selves an intriguing one. Isekai Yakkyoku is definitely more of the Shounen genre than Healer Girl but the overall feeling and vibes from the protagonists are very similar 

Both main character comes to new world an introduces the world to new earth items. Retirement has a focus on everyday things whereas Pharmacy focuses on medicine. They both deal a lot with royalty and noble society 

Similarities: Sasaki to Pii-chan and Parallel World Pharmacy both involve protagonists who are transported to fantasy worlds through isekai premises. They explore themes of adapting to new environments and utilizing modern knowledge or skills to thrive in their new settings. Additionally, both series incorporate elements of fantasy and exploration as the main characters navigate unfamiliar territories and interact with new cultures. Differences: While Sasaki to Pii-chan focuses on the protagonist's journey to build wealth through interdimensional trading and entrepreneurial endeavors, Parallel World Pharmacy centers on a pharmacologist reincarnated into a medieval fantasy world, applying modern pharmaceutical knowledge to heal others. The former emphasizes economic growth and strategic trading, while the latter delves into medical practices and societal dynamics within a fantastical setting. In my opinion, while both series explore isekai themes of adaptation and skill application in new worlds, Sasaki to Pii-chan offers a narrative focused on entrepreneurship and economic strategies, while Parallel World Pharmacy provides a unique perspective on medical practices and societal impact in a fantasy setting. read more 

Both MCs are experienced pharmasists who impress others with their knowledge and problem solving skills. They are both independent and positive characters who love the work they do. 

The vibe from character feel the same and also good for killing some time for this summer!