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陳平


陳平
教授
化學館 B678室
電話: 02-3366-9789
傳真: 02-3366-8671
實驗室
學術典藏
研究興趣

  • 非自然界胺基酸之合成、對胜肽構形之影響與應用 

  • 含氟胺基酸、帶電荷之胺基酸

  • a螺旋、b摺板、核酸辨認、細胞穿膜與藥物輸送

簡歷

  • 1992 年臺灣大學化學系學士

  • 1998 年美國加州理工學院化學博士

  • 1998-2002 年賓州大學醫學院博士後研究

  • 2002-2008 年任紐約州立大學水牛城分校助理教授

  • 2008-2015 年任臺灣大學化學系副教授

  • 2015 年迄今任臺灣大學化學系教授 

榮譽事項

  • 2003 年NYSTAR James D. Watson 年輕學者獎

  • 2008-2013 年傑出人才發展基金會積極爭取國外優秀年輕學者獎

  • 2010 年亞洲尖端有機化學講座獎

  • 2010 年中國化學會傑出青年化學獎章

  • 2010、2012-2014 年國立臺灣大學教學優良獎

研究內容
代表著作

  1. Chang, J.-Y.; Pan, Y.-J.; Huang, P.-Y.; Sun, Y.-T.; Yu, C.-H.; Ning, Z.-J.; Huang, S.-L.; Huang, S.-J.; Cheng, R. P.* “Effect of charged amino acid side chain length on diagonal cross-strand interactions between carboxylate- and ammonium-containing residues in a beta-hairpin”  Molecules 2022,  27, in press.

  2. Chang, J.-Y.; Li, N.-Z.; Wang, W.-M.; Liu, C.-T.; Yu, C.-H.; Chen, Y.-C.; Lu, D.; Lin, P.-H.; Huang, C.-H.; Kono, O.; Yang, T.-Y.; Sun, Y.-T.; Huang, P.-Y.; Pan, Y.-J.; Chen, T.-H.; Liu, M.-C.; Huang, S.-L.; Huang, S.-J.; Cheng, R. P.* “Longer charged amino acids favor beta-strand formation in hairpin peptides”  J. Pept. Sci. 2021,  27, e3333.

  3. Huang, C.-H.; Wong, T. W.; Yu, C.-H.; Chang, J.-Y.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.* “Swapping the positions in a cross-strand lateral ion-pairing interaction between ammonium- and carboxylate-containing residues in a beta-hairpin”  Molecules 2021,  26, 1346.

  4. Wang, W.-M.; Yu, C.-H.; Chang, J.-Y.; Chen, T.-H.; Chen, Y.-C.; Sun, Y.-T.; Wang, S.-H.; Jao, S.-C.; Cheng, R. P.* “Insertion of Pro-Hyp-Gly provides 2 kcal/mol stability but attenuates the specific assembly of ABC heterotrimeric collagen triple helices”  Org. Biomol. Chem. 2021,  19, 1860–1866.

  5. Wu, P.-Y.; Chen, C.-Y.; Li, J.-H.; Lin, J.-K.; Chen, T.-H.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.* “Effect of arginine deimination and citrulline side chain length on secondary structure formation”  ChemBioChem 2019,  20, 2118–2124.

  6. Liu, M.-C.; Chen, C.-Y.; Chiang, C.-H.; Wang, W.-M.; Cheng, R. P.* “Effect of lysine methylation and acetylation on the RNA recognition and cellular uptake of Tat-derived peptides”  Bioorg. Med. Chem. 2016,  24, 5047–5051.

  7. Wu, C.-H.; Chen, Y.-P.; Liu, S.-L.; Chien, F.-C.; Mou, C.-Y.; Cheng, R. P.* “Attenuating HIV Tat/TAR-mediated protein expression by exploring the side chain length of positively charged residues”  Org. Biomol. Chem. 2015,  13, 11096–11104.

  8. Kuo, H.-T.; Liu, S.-L.; Chiu, W.-C.; Fang, C.-J.; Chang, H.-C.; Wang, W.-R.; Yang, P.-A.; Li, J.-H.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.* “Effect of charged amino acid side chain length on lateral cross-strand interactions between carboxylate- and guanidinium-containing residues in a beta-hairpin”  Amino Acids 2015,  47, 885–898.

  9. Li, J.-H.; Chiu, W.-C.; Yao, Y.-C.; Cheng, R. P.* “Effect of arginine methylation on the RNA recognition and cellular uptake of Tat-derived peptides”  Biorg. Med. Chem. 2015,  23, 2281–2286.

  10. Kuo, H.-T.; Yang, P.-A.; Wang, W.-R.; Hsu, H.-C.; Wu, C.-H.; Ting, Y.-T.; Weng, M.-H.; Kuo, L.-H.; Cheng, R. P.* “Effect of side chain length on intrahelical interactions between carboxylate- and guanidinium-containing amino acids”  Amino Acids 2014,  46, 1867–1883.

  11. Wu, C.-H.; Weng, M.-H.; Chang, H.-C.; Li, J.-H.; Cheng, R. P.* “Effect of each guanidinium group on the RNA recognition and cellular uptake of Tat-derived peptides”  Bioorg. Med. Chem. 2014,  22, 3016–3020.

  12. Kuo, H.-T.; Fang, C.-J.; Tsai, H.-Y.; Yang, M.-F.; Chang, H.-C.; Liu, S.-L.; Kuo, L.-H.; Wang, W.-R.; Yang, P.-A.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.* “Effect of charged amino acid side chain length on lateral cross-strand interactions between carboxylate-containing residues and lysine analogs in a beta-hairpin”  Biochemistry 2013,  52, 9212–9222.

  13. Wu, C.-H.; Chen, Y.-P.; Wu, S.-H.; Hung, Y.; Mou, C.-Y.*; Cheng, R. P.* “Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side chain”  ACS Appl. Mat. Inter. 2013,  5, 12244–12248

  14. Kuo, L.-H.; Li, J.-H.; Kuo, H.-T.; Hung, C.-Y.; Tsai, H.-Y.; Chiu, W.-C.; Wu, C.-H.; Wang, W.-R.; Yang, P.-A.; Yao, Y.-C.; Wong, T. W.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.* “Effect of charged amino acid side chain length at non-hydrogen bonded strand positions on beta-hairpin stability”  Biochemistry 2013,  52, 7785–7797.

  15. Wu, C.-H.; Chen, Y.-P.; Mou, C.-Y.; Cheng, R. P.* “Altering the Tat-derived peptide bioactivity landscape by changing the arginine side chain length”  Amino Acids 2013,  44, 473–480.

  16. Cheng, R. P.*; Wang, W.-R.; Girinath, P.; Yang, P.-A.; Ahmad, R.; Li, J.-H.; Hart, P.; Kokona, B.; Fairman, R.; Kilpatrick, C.; Argiros, A. “Effect of glutamate side chain length on intrahelical glutamate-lysine ion pairing interactions”  Biochemistry 2012,  51, 7157–7172.

  17. Cheng, R. P.*; Weng, Y.-J.; Wang, W.-R.; Koyack, M. J.; Suzuki, Y.; Wu, C.-H.; Yang, P.-A.; Hsu, H.-C.; Kuo, H.-T.; Girinath, P.; Fang, C.-J “Helix formation and capping energetics of arginine analogs with varying side chain length”  Amino Acids 2012,  43, 195–206.

  18. Cheng, R. P.*; Girinath, P.; Suzuki, Y.; Kuo, H.-T.; Hsu, H.-C.; Wang, W.-R.; Yang, P.-A. Gullickson, D.; Wu, C.-H.; Koyack, M. J.; Chiu, H.-P.; Weng, Y.-J.; Hart, P.; Kokona, B.; Fairman, R.; Lin, T.-E.; Barrett, O. “Positional effects on helical Ala-based peptides”  Biochemistry 2010,  49, 9372–9384.

  19. Chiu, H.-P.; Kokona, B.; Fairman, R.; Cheng, R. P.* “Effect of highly fluorinated amino acids on protein stability at a solvent-exposed position on an internal strand of protein G B1 domain”  J. Am. Chem. Soc. 2009,  131, 13192–13193.

更新日期: 2022-03-23

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2023-02-22

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