This will go down in history as one of science and medical research's greatest achievements. Perhaps the most impressive.
I put together a preliminary timeline of some key milestones to show how several years of work were compressed into months.
As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://medrxiv.org/content/10.1101/2022.11.19.22282525v1…
Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion.
https://erictopol.substack.com/p/the-bq11-variant-story…
However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability
My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe.
The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave.
Our work with the @CJohnstonLab1 lab out today @Nature demonstrating the intratumoral microbiota impacts spatial, cellular and transcriptional heterogeneity in human cancer. Monster tweetorial below from Chris. twitter.com/CJohnstonLab1/…
and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level
https://science.org/doi/10.1126/sciimmunol.add9947…
I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines
引用ツイート
Eric Topol
@EricTopol
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An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation
https://nytimes.com/2022/11/18/health/covid-nasal-vaccines-warp-speed.html… by @benjmueller
w/ @VirusesImmunity@florian_krammer