It takes weeks to switch from original spike to e.g. Delta spike in vaccines.
Variant boosters won’t work (OAS) and that’s why you don’t even see animal studies that test 2-3 original Wuhan doses + a ‘variant’ booster. It seems everyone knows this except for the general public.
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It’s the same in breakthrough infections: only a small fraction of vaccinated people seem to develop nucleocapsid (N) antibodies after being infected, and some of them may even had undetected, low N Ab in a prior infection. Original antigenic sin at work.
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J Sato
@j_sato
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英国報告assets.publishing.service.gov.uk/government/upl で気になった点
自然感染率を示すN蛋白抗体保有率が、陽性者数増加のようには増えない
モデルナ第3相論文Supplementary奥
nejm.org/doi/full/10.10
N蛋白抗体保有
・自然感染：50-66%
・
2回後感染：23％
2回後感染は自然感染とは獲得する免疫が大きく異なる
2回後感染：23％
2回後感染は自然感染とは獲得する免疫が大きく異なるShow this thread
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Profound OAS in Beta boosting primates.
“primary immunization plays a key role in shaping the overall serum antibody epitope repertoire.”
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…and profound OAS in Omicron boosting of primates.
“an Omicron boost may not provide greater immunity or protection compared to a boost with the current mRNA-1273 vaccine.”
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Is there a way to "un-vax" people in order to clean up the slate and start over with updated code ?
That would be a welcome "great reset" 
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I’m afraid not. The only solution is to let affinity maturation occur. Which means months, not weeks, between vaccine doses and a smaller priming dose. Too late
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Gabor Erdosi 
@gerdosi
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Replying to @andreeeee95
OAS = original antigenic sin
Despite introducing altered antigens, the immune response to the old ones will be boosted.
twitter.com/gerdosi/status
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So can you spell out what this means immunity wise for vaccinated people who subsequently get infected by Delta?
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I think that not much so far. The distance between the Wuhan spike and the Delta spike is not that far away so that their immunity can make good use of the vaccine priming.
What happens later will turn out in half a year or so…
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That’s what I really miss from the literature. Testing the developments in Ab responses when boosting on top of 2 and 3 precious injections with the ‘ancestral’ spike. I.e. real life scenarios.
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And of course, there's the great chance the mRNA vaccine did not take in you to begin with. So few individuals are post vax testing for antibodies, and we still don't even know as yet the amount of antibodies needed for protection from covid.
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That’s incorrect. And it takes a week or less to develop the variant vaccine. It’s a cost/benefit analysis of added efficacy.
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This is so basic, but so basic, that it is incredible that it is not public knowledge.
But obviously big pharma knows it.
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When you say it takes weeks, are you saying it could easily have been done by now, and are you saying there is a reason such as OAS that they have not? Just trying to understand as layman.
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It can take 5 days even, once they know which strain they are targeting. Testing is another issue, true efficacy is another, and long term with mRNA is a third factor unknown.
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I think a majority of vaxxed and non vaxxed are experiencing this. Fatigue and frustration from the pandemic, lockdowns, and volatile divisive politics :(
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I don’t know how this fits in, if it does at all.
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Based on what I know, I think this is probably correct. There's a huge financial incentive to launch a Delta-booster — why haven't they?
For this reason I've included this tweet in Weekly Crystallizations #060.
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jessems.eth
@jessems
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The latest Weekly Crystallizations - Highlights of sensemaking on Twitter is out!
• Vaccine-effectiveness goes negative for age groups >30
• Mounting evidence natural immunity is the better deal
• Updates out of police state Australia
• And more...
jessems.substack.com/p/weekly-cryst
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