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A brief history... The biggest change to our diet in the last 100 years has been these oils. Before 1900s everyone used animal fats to cook. However, since then animal fat consumption has cratered and vegetable oil consumption has increased 1000x.
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I will spare you the entire story, but heart disease ramped up in the early 1900s... Ancel Keys stepped in, posited that LDL contributed to heart disease and that saturated fat was the culprit for raising LDL. This was the "diet-heart hypothesis"
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The AHA signed off on polyunsaturated fats as heart healthy in the mid 1900s (oh and they were paid $1.7m by P&G who sold crisco, a vegetable oil product) And since then we've been completely indoctrinated into the view that saturated fat clogs your arteries and PUFAs clear them
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Meanwhile, despite Americans dutifully following this advice, diabetes, heart disease, alzheimers and cancer are skyrocketing. Modern medicine wants us to believe that these diseases are unrelated, but they all tend to occur together and are tied to mitochondrial dysfunction
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I believe one of the things that ties together all the mitochondrial dysfunction are these seed oils via three main mechanisms: First, they remodel the cardiolipin structure of mitochondria. This causes: - energy to leak from mitochondria - cellular death - leakage of potassium
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Second, these PUFAs are highly susceptible to damage from the unsaturated bonds and they break down into toxic byproducts like HNE, acrolein and MDA when oxidized. These byproducts are linked to cancer, obesity, diabetes and alzheimers disease, as I will describe below.
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When people consume seed oils, they accumulate them in their fat The average human today has over 20% of their fat as linoleic acid, vs just 7% 50 years ago Similar to letting a bottle of oil sit out in the sun, over time this causes your body to go rancid This is sickness
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#1 HEART DISEASE The reason we are in this mess is because some studies in the 1950s suggested that saturated fats raised LDL cholesterol and LDL causes heart disease.
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However, the cholesterol in the heart disease plaques first have to be OXIDIZED to be taken up into the arteries...something diet heart hypothesis proponents totally overlooked. And it is linoleic acid (from seed oils) that causes the LDL particles to oxidize.
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After being oxidized, immune cells take it up and form plaques in the arteries. And these studies confirm that -- looking into the actual plaque in human aortas, they are comprised of polyunsatrated omega 6 fatty acids
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The sad part is that we knew this 50 YEARS AGO. This trial done in the 1960s was kept unpublished... PUFA doubled heart attacks and increased death rates There was a "22% higher death rate for each 30 ng / dL reduction in cholesterol from linoleic acid."
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Another study, the sydney heart health study, showed that the group consuming more vegetable oil had a 62% higher rate of death compared to the group eating less. This would put it on par with the highest death risk factors there is.
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In the gold standard of RCTs, this shows that isolated omega 6 specific interventions increased heart disease and death. (The confusion today lies in that many of the studies that increase PUFA intake ALSO increase omega 3 consumption, which may decrease heart disease risk).
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