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RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus
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1
AMALNA Consulting, Black Rock, Melbourne, VIC 3193, Australia
2
College of Science, Engineering and Health, RMIT University, Melbourne, VIC 3000, Australia
3
QuantBioRes A/S - QBR A/S, 2860 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(11), 4053; https://doi.org/10.3390/app10114053
Received: 10 May 2020
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Revised: 5 June 2020
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Accepted: 10 June 2020
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Published: 11 June 2020
(This article belongs to the Special Issue Spreading of Infection Diseases like COVID-19 and Influenza: Modelling and Propagation Control)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus causing a worldwide pandemic. It is infecting respiratory organs and, in more severe cases, the lungs, where it is infecting the human cells through the angiotensin-converting enzyme 2 (ACE2) receptor. In severe cases, it is characterized not only by difficulties in breathing through infected lungs, but also with disproportionally and, thus far, unexplained low levels of oxygen in the blood. Here, we propose that, besides the infection of respiratory organs through ACE2 receptors, there is an additional infection in the red blood cells (erythrocytes). There could be a possible for SARS-CoV-2 to pass through the alveoli membrane in the lungs and infect the red blood cells through another receptor. Using our own biophysical model, the Resonant Recognition Model, we propose that the red blood cell (RBC) Band3 protein on the surface of red blood cells is a possible entry point for the SARS-CoV-2 virus into red blood cells.
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Keywords:
COVID-19; SARS-CoV-2; coronavirus; ACE2; blood cells; protein–receptor interaction; resonant recognition model
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MDPI and ACS Style
Cosic, I.; Cosic, D.; Loncarevic, I. RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus. Appl. Sci. 2020, 10, 4053. https://doi.org/10.3390/app10114053
AMA Style
Cosic I, Cosic D, Loncarevic I. RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus. Applied Sciences. 2020; 10(11):4053. https://doi.org/10.3390/app10114053
Chicago/Turabian StyleCosic, Irena, Drasko Cosic, and Ivan Loncarevic. 2020. "RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus" Applied Sciences 10, no. 11: 4053. https://doi.org/10.3390/app10114053
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