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Let me say right off: This does NOT mean people who have been infected can skip vaccines. But it does mean that those who were infected and then vaccinated have what one researcher called "bulletproof" protection against variants, and will probably never need boosters

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It's the combo of infection and vaccination that is powerful here. The results will most likely not apply to those who never had Covid and were vaccinated, because immune memory is not consolidated the same way after vaccination as it is after infection.

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One study analyzed bone marrow cells in people who recovered from Covid and showed that even a year after infection, most people have memory cells that can produce antibodies as needed, even if blood levels of the antibodies are low. (Most is not all, though, so get vaccinated!)

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And the second showed that memory B cells keep maturing and broadening their repertoire over at least a year. And when people who've recovered from Covid get vaccinated, their neutralizing ability goes through the roof. So they will essentially be set against any variants.

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Immunity to the Coronavirus May Last Years, New Data Hint

This is not altogether surprising given the study I covered in November, but the bone marrow analysis is cool, as is the evidence of continuing memory B cell maturation. The human body is a wondrous machine

Blood samples from recovered patients suggest a powerful, long-lasting immune response, researchers reported.

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Many thanks to

and

for this interesting work, and to

@JenGommerman

@SCOTTeHENSLEY

and

@PepperMarion

for their perspective

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Good thing this virus isn't changing or anything. Otherwise it might be able to reinfect people.

Ryan Hisner

@LongDesertTrain

Dr. Hilary Edelstein, PhD

Also worth noting that one study found genetically identical HCoV-229E was able to reinfect 2/3 of subject 12 months after the original infection. ncbi.nlm.nih.gov/pmc/articles/P

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Real fantastic piece — very clear distillation of the science. Thank you for all the great work you do.

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interesting

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Thanks Dr.

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What amount of time passage, post infection, is optimal to receive vaccine? Thanks

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this is super cool stuff. Does this mean that my nursing 1 yr old (who had covid when I did) who won’t be eligible for vaccination, is safer (I know my breast milk has antibodies bc I took part in a research study & they unblinded my results!)?

John-Peter G. Mall, PhD

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Tell us more...

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Immunity to viruses often tapers as antibodies break down without replacement. Long-term immunity to #COVID19 was found, but only to the original and its close mutations, such as B.1.1.7 from the UK. (It may not apply to future ones, or India's B.1.617.)

引用ツイート

Apoorva Mandavilli

@apoorva_nyc

· 5月26日

NEW: Immunity to the coronavirus lasts at least a year, possibly a lifetime, and improves over time especially after vaccination, according to two new studies.

nytimes.com/2021/05/26/hea

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That would be wonderful!

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Thank you!

Mitch "The Wałęsa Project" Berg, BA

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Karen hardest hit.

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Maintaining immunity, however attained, would seem a good thing. But if I need a booster like the Tetanus vaccine, or yearly like influenza, as recommended by the medical professionals from whom I seek guidance, I’m good.

Shanna dundas

@Sdhey19

Yep, I figured it would be a yearly booster, like my flu shot. No biggie. If not, that’s just fine too...

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This is an odd way of formulating this. Immunity to common coronaviruses that cause colds is long lasting — that’s *why* they only cause mild colds and don’t put us on a ventilator, right?

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This is good news!

Indeed!

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Interesting because B cell depleting therapies - which are used to treat certain inflammatory diseases - severely blunt even the initial reaction to the vaccine

Amazonia

@Jandal_It

Would you be able to detail those therapies here? I am in a group of people with inflammatory disease, and it would be really useful to have information on this to share. It would help inform people as regards the need to vaxx.

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@WasOnceLou

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The good news keeps coming in the Biden years

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This is only anecdotal, but two people I know very well who had COVID (with positive tests) caught it again more than 90 days after, had pretty bad cases again, and tested positive. One in 20s, one in early 70s.

Tom Fenn

@tomfenn8