About esc

Esc (Immune escape variants in SARS-CoV-2) is a comprehensive and manually curated compendium of genetic variants in SARS-CoV-2 associated with immune escape. The data on variants and associations have been compiled from published literature as well as preprints and includes a variety of antibodies ranging from monoclonal as well as oligoclonal and convalescent plasma panels.

The ESC resource provides a user friendly and searchable interface to query and understand the variants and their functional annotations in detail. This resource may not be used for clinical decision making or intervention.

search
Example Search :
Variant   A475V N440K E484K K417N
Gene   S ORF3a ORF1ab
Antibody name   REGN10933
Cite this Resource
Mercy Rophina, Kavita Pandhare, Afra Shamnath, Mohamed Imran, Bani Jolly, Vinod Scaria. Comprehensive resource for SARS-CoV-2 immune escape variants and their annotations (Web Resource: http://clingen.igib.res.in/esc/)
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Last Updated : 18/02/2021

Total number of entries compiled : 532

Number of unique variants : 146

Unique antibodies compiled : 75

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We sincerely acknowledge the availability of genome sequence data, authors from a range of originating and submitting labs on GISAID for collaborative efforts

Acknowledgement table can be downloaded here

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The genetic epidemiology of novel and emerging pathogens in India aims to use genomics technologies to provide insights into the genetic structure, evolution and use the information for translational research.
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The COVID-19 Open Research, Data and Resources initiative at the Vinod Scaria Lab at CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB) aims to provide a platform for Open Research on COVID-19 [read more]