Vitamin-Cノ實驗的動脈硬化症ニ及ス影響 : 第3編 Vitamin-CノVitamin-Dニヨル動脈硬化症ニ及ス影響 The Influence of Vitamin C on the experimental Arteriosclerosis : Part. III. The influence of vitamin C on the arteriosclerosis produced by vitamin D

In the previous reports, I have pointed out that vitamin C has both preventive and therapeutic effect on the adrenalin and cholesterin type arteriosclerosis. This time I have performed the experiments to determine the effect of vitamin C on the arteriosclerosis produced by feeding vitamin D. For the experimental animals I have used matured domestic rabbits weighing around 2 kilo grams. Vitacimin (vitamin C 1cc=50mg) prepared by Takeda and ovoral (vitamin D 1cc=5mg) prepared by Fujizawa were used for the experimental materials. 1) In order to determine the preventive effect of vitamin C on the arteriosclerosis caused by vitamin D, following procedure was used. (a) As a control group animals were fed 1.3cc of ovoral through the mouth every day for sixty days. (b) The other group of animals were given 1.3cc of ovoral every day and 0.5cc of vitacimin was injected intravenously through the ear veins of the animals for sixty days. 2) To ascertain therapeutic effect of vitamin C on the arteriosclerosis caused by vitamin D, one group of animals were fed 1.3cc of ovoral through the mouth for sixty days and left alone for another sixty days. The other group was fed 1.3cc of ovoral for sixty days and again 0.5cc of vitacimin was injected once a day for another sixty days. 3) The similar experiments were carried out on the castrated animals. The methods used to determine the sedimentation rate of the erythrocytes, viscosity of the serum, vitamin C content of the adrenal gland and the observations made on the large arteries were the same as the first report. Following are the results of the experiments. 1) Vitamin C has definite preventive action on the arteriosclerosis produced by feeding vitamin D in normal and castrated animals. 2) Vitamin C has definite therapeutic effect on the arteriosolerosis produced by feeding vitamin D. 3) Vitamin C inhibits the decreasing vitamin C content of adrenal gland caused by feeding vitamin D. 4) Vitamin C inhibits the slower sedimentation rate of the erythrocytes and rise of the viscosity of serum caused by feeding vitamin D in normal and castrated animais. 5) Abnormal sedimentation rate of the erythrocytes and viscosity of the serum caused by feeding vitamin D can be made to return to normal conditions by injecting vitamin C intrvenosly. 6) The degree of arteriosclerosis produced by feeding vitamin D is directly proportional to the slower sedimentation rate of the erythrocytes and rise of the viscosity of the serum.