鶏痘ウイルスの飲水投与による免疫 Vaccination against Fowlpox Virus Via Drinking Water

鶏痘ウイルスF132-c株を用いて飲水投与による免疫を試みたところ,10^<4〜5>TCID_<50>/doseのF132-c株を1回飲水投与した場合攻撃に対し防御できなかったが,同量を2回飲水投与したところ防御した.1回目投与により弱い免疫反応が起こり,2回投与によりブースターが起きたと推測される.今回の結果は,飲水投与型ワクチンの実用化への可能性を示し,それにより鶏痘ワクチンの省力化が期待できる.

The oral vaccination against Fowlpox was investigated via drinking water containing the F132-c strain of Fowlpox virus to be effective even though the vaccine virus-titer was 10⁴ TCID ₅₀/dose each time. When the virus-titer of the F132-c strain was 10^4-5TCID₅₀/dose per single drinking water vaccination, 90% or more of chickens were not protected, however, they were protected when vaccinated twice via drinking water. A weak immune response occurred by a slight infection after the first vaccination, and due to memory cells, a booster could work well after the second vaccination. These results suggest the possibility of reducing both the amount of virus required for a vaccine via drinking water and the labor cost in the field.<br>