Danish Memon

Thrilled to share our new Nature Genetics paper on immunogenomics of ovarian cancer! We show ubiquitous tumour-immune microenvironmental variability and we uncover an unanticipated immunogenic effect of chemotherapy. Fantastic collaboration with Weigelt, Snyder and

@EvisSala

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Pedro Beltrao

@pedrobeltrao

5月27日

New lab preprint - Deep mutational scanning can tell us about the function of individual protein positions.

@Ally_Dunham

normalised DMS data for 6291 positions in 30 proteins to ask how many amino acid functions are there and how frequently are they used

Exploring amino acid functions in a deep mutational landscape

Amino acids fulfil a diverse range of roles in proteins, each utilising its chemical properties in different ways in different contexts to create required functions. For example, cysteines form...

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A tiny contribution of our lab to this amazing effort to identify SARS CoV2 human protein interactions with a goal of finding new drugs. Achieved at an unprecedented speed for such a study.

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Krogan Lab

@KroganLab

· 3月23日

Our paper is out on @biorxivpreprint describing our SARS CoV2-human protein-protein interaction map and drug predictions from the data. It was a honor to work with so many fantastic scientists around the world. -Nevan biorxiv.org/content/10.110

Less than 5% of human phosphosites have a known function. Also published today -

@d0choa

et al. have set out to create a high quality catalog of human phosphosites and an integrated score than can rank phosphosites critical for the cell

@NatureBiotech

The functional landscape of the human phosphoproteome

Phosphorylation sites are ranked for functional relevance using a comprehensive, high-quality human phosphoproteome.

nature.com

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Danish Memonさんがリツイート

Victoria University of Wellington

@VicUniWgtn

2019年10月4日

#VicUniWgtn research by Professor Paul Atkinson,

@MunkacsiLab

, Dr Bede Busby from

@embl

and others on the role of #genetic networks in how people react to #cholesterol medication is a significant step towards more personalised medication bit.ly/2pJfi2N

Just out in

's PhD project studying why gene copy number changes are attenuated at the protein level and the implications this has on linking eQTLs to phenotypes. (w

)

Multi-omics characterization of interaction-mediated control of human protein abundance levels

Proteogenomic studies of cancer samples have shown that copy number variation can be attenuated at the protein level, for a large fraction of the proteome, likely due to the degradation of unassemb...

Very happy to see my first first-author research article published today in

@PLOSBiology

. Pedro and I worked on this during my PhD on kinase specificity. Good progress has been made already, but will be very exciting to see how this can be taken further in the years to come...

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Pedro Beltrao

@pedrobeltrao

· 2019年6月25日

Now published in @PLOSBiology - @dbradley534 's study of the evolution of kinase-substrate active site recognition. When during evolution did kinases learn to recognise different types of motifs ? (quick summary and future directions) journals.plos.org/plosbiology/ar

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Huge congrats to Zainab Hakim who joined my group to work on this paper which documents the most comprehensive analysis of ozone in models and observations across India. Ozone is a really important molecule in this region and there is more we need to understand about it.

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AtmosphericChemistry

@EGU_ACP

· 2019年5月16日

New research article: Evaluation of tropospheric ozone and ozone precursors in simulations from the HTAPII and CCMI model intercomparisons – a focus on the Indian subcontinent doi.org/10.5194/acp-19

Marta Strumillo's main PhD work now online - she used 530,000 phosphosites from 40 eukaryotic species to search for "ultra-conserved" phosphorylation within globular protein domains. Such hotspots of phosphorylation are enriched for functional regions nature.com/articles/s4146

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Join the

group! Awesome group, supervisor and science! And of course one of the most exciting research campuses in the world!

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EMBL-EBI Jobs

@EMBLEBIjobs

· 2019年4月3日

Two core funded #postdoc positions are available in the broad areas of evolutionary #systemsbiology; proteomic based study of phosphorylation/ubiquitin signalling or genotype-to-phenotype analysis. embl.de/jobs/searchjob #EMBLjobs #PhD #lifesciences

Blog post - Some thoughts on our research over the past 6 years on genotype-to-phenotype relationships and some discussion on alternatives to QTL everything. (Deep mutational scanning and hierarchical representations of cellular functions) evocellnet.com/2019/03/resear

Pre-computed effects of all possible variants on protein stability (both PDB and homology models), protein-protein interactions, TFBSs, PTMs, and more are now available via our FTP server: ftp://ftp.ebi.ac.uk/pub/databases/mutfunc See mutfunc.com for the web version

Our preprint using drug and CRISPR data to identify functional fusions in cancer is now out (biorxiv.org/content/10.110). New rare actionable fusions in RAF, BRD4, ROS, and recurrent fusions in YAP1.

#CRISPR

An interesting work on functional annotation, prioritisation and scoring of human phosphosites #phosphoproteomics

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Pedro Beltrao

@pedrobeltrao

· 2019年2月6日

Thousands of phosphosites have been discovered with <5% having a known function. In our new preprint @d0choa uses a machine learning approach to address this gap If you care what phosphosites may regulate your protein/process of interest read on biorxiv.org/content/10.110

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