国際誌

原著論文（*責任著者）

  1. Araki, T., Ikegaya, Y., *Koyama, R.
    Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures.
    Neuropsychopharmacol. Rep., in press.
  2. Kono R, Kim GL, Nagata H, Ikegaya Y, *Koyama R.
    Induced neuronal activity does not attenuate amyloid beta-induced synaptic loss in vitro.
    Neuropsychopharmacology Reports, in press.
  3. Orita K, Sawada K, Koyama R, *Ikegaya Y.
    Deep learning-based quality control of cultured human-induced pluripotent stem cell-derived cardiomyocytes.
    Journal of Pharmacological Sciences, in press.
  4. Andoh M, Shibata K, Okamoto K, Onodera J, Morishita K, Miura Y, Ikegaya Y, *Koyama R.
    Exercise reverses behavioral and synaptic abnormalities after maternal inflammation.
    Cell Reports, 27:2817-2825, 2019.
  5. Kasahara Y, Igata H, Sasaki T, Ikegaya Y, *Koyama R.
     The pharmacological assessment of GABAA receptor activation in experimental febrile seizures in mice.
    eNeuro, 6:1, 2019.
  6. Hoshi Y, Okabe K, Shibasaki K, Funatsu T, Matsuki N, Ikegaya Y, *Koyama R.
    Ischemic brain injury leads to brain edema via hyperthermia-induced TRPV4 activation. 
    Journal of Neuroscience, 38:5700-5709, 2018.
  7. Hiragi T, Andoh M, Araki T, Shirakawa T, Ono T, *Koyama R, Ikegaya Y.
    Differentiation of human induced pluripotent stem cell (hiPSC)-derived neurons in mouse hippocampal slice cultures.
    Frontiers in Cellular Neuroscience, 11:143, 2017.
  8. Luo C, *Koyama R (Co-first), Ikegaya Y.
    Microglia engulf viable newborn cells in the epileptic dentate gyrus.

    Glia, 64:1508-1517, 2016.

  9. Andoh M, *Koyama R (Co-first), Ikegaya Y.
    Severity of kainic acid-induced seizures is not aggravated in the maternal immune activation mouse model of gestational poly(I:C) exposure.

    Journal of Autism and Epilepsy, 1:1013, 2016.

  10. Kasahara Y, *Koyama R(Co-first), Ikegaya Y.
    Depth and time-dependent heterogeneity of microglia in mouse hippocampal slice cultures.
    Neuroscience Research, 111:64-69, 2016.

  11. Mikami Y, Kanemaru K, Okubo Y, Nakaune T, Suzuki J, Shibata K, Sugiyama H, Koyama R, Murayama T, Ito A, Yamazawa T, Ikegaya Y, Sakurai T, Saito N, Kakizawa S, *Iino M.

    Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death.

    EBioMedicine, 16:30369-30373, 2016. 

  12. Ohki M, Sugiyama K, Kawaia F, Tanaka H, Nihei Y, Unzai S, Takebe M, Matsunaga S, Adachi S, Shibayama N, Zhou Z, Koyama R, Ikegaya Y, Takahashi T, Jeremy R.H. Tame RH J, Iseki M, *Park S.
    Structural basis for photoactivation of a light-regulated adenylate cyclase from the photosynthetic cyanobacterium Oscillatoria acuminatea.
    Proc Natl Acad Sci U S A., 113:6659-6664, 2016.

  13. Tao K, Ichikawa J, Matsuki N, Ikegaya Y, *Koyama R.
    Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice.
    Neuroscience, 318:34-44, 2016.

  14. Zhou Z, Tanaka KF, Matsunaga S, Iseki M, Watanabe M, Matsuki N, Ikegaya Y, *Koyama R.
    Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis.
    Scientific Reports, 5:19679, 2016

  15. Sajo M, Sugiyama H, Yamamoto H, Tanii T, Matsuki N, Ikegaya Y, *Koyama R.
    Neuraminidase-Dependent Degradation of Polysialic Acid Is Required for the Lamination of Newly Generated Neurons.
    PLoS One, 11:e0146398, 2016

  16. Tao K, Matsuki N, and *Koyama R.
    AMP-Activated Protein Kinase (AMPK) mediates activity-dependent axon branching by recruiting mitochondria to axon.
    Developmental Neurobiology, 74: 557-573, 2014.

  17. Shibata K, Nakahara S, Shimizu E, Yamashita T, Matsuki N, and *Koyama R.
    Repulsive guidance molecule a (RGMa) regulates hippocampal mossy fiber branching in vitro.
    Neuroreport, 24: 609-615, 2013.

  18. *Koyama R, Tao K, Sasaki T, Ichikawa J, Miyamoto D, Muramatsu R, Matsuki N, and Ikegaya Y.
    GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy.
    Nature Medicine, 18: 1271-1278, 2012.

  19. Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME, Barres BA, and *Stevens B.
    Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.
    Neuron, 74: 691-705, 2012.

  20. Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, *Tomita T, and Iwatsubo T.
    Activity-dependent proteolytic cleavage of Neuroligin-1.
    Neuron, 76: 410-422, 2012.

  21. Tamura M, Sajo M, Kakita A, Matsuki N, and *Koyama R.
    Prenatal stress inhibits neuronal maturation through downregullation of mineralocorticoid receptors.
    J. Neurosci., 31:11505–11514, 2011.

  22. Muramatsu R, Nakahara S, Ichikawa J, Watanabe K, Matsuki N, and *Koyama R.
    The ratio of 'deleted in colorectal cancer' to 'uncoordinated-5A' netrin-1 receptors on the growth cone regulates mossy fibre directionality.
    Brain, 133:60-75, 2010.

  23. Nakahara S, Tamura M, Matsuki N, and *Koyama R.
    Neuronal hyperactivity sustains the basal dendrites of immature dentate granule cells: Time-lapse confocal analysis using hippocampal slice cultures.
    Hippocampus, 19:379-391, 2009.

  24. Tamura M, Tamura N, Ikeda T, Koyama R, Ikegaya Y, Matsuki N, and *Yamada MK. Influence of brain-derived neurotrophic factor on pathfinding of dentate granule cell axons, the hipocampal mossy fibers.
    Mol Brain., 2:2, 2009.

  25. Ohshima Y, *Kubo T, Koyama R, Ueno M, Nakagawa M, and *Yamashita T.
    Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyrus in the hippocampus by the chemokine stromal cell-derived factor 1α.
    J. Neurosci., 28:8344-8353, 2008.

  26. Yamada RX, Sasaki T, Ichikawa J, Koyama R, Matsuki N, and *Ikegaya Y.
    Long-range axonal calcium sweep induces axon retraction.
    J. Neurosci., 28:4613-4618, 2008.

  27. Muramatsu R, Ikegaya Y, Matsuki N, and *Koyama R.
    Early-life status epilepticus induces ectopic granule cells in adult mice dentate gyrus.
    Exp. Neurol., 211:503-510, 2008

  28. Muramatsu R, Ikegaya Y, Matsuki N, and *Koyama R.
    Neonatally born granule cells numerically dominate adult mice dentate gyrus.
    Neuroscience, 148:593-598, 2007.

  29. Ichikawa J, Yamada RX, Muramatsu R, Ikegaya Y, Matsuki N, and *Koyama R.
    Cryopreservation of granule cells from postnatal rat hippocampus.
    J. Pharmacol. Sci., 104:387-391, 2007.

  30. Koyama R, Muramatsu R, Sasaki T, Kimura R, Ueyama C, Tamura M, Tamura N, Ichikawa J, Takahashi N, Usami A, Yamada MK, Matsuki N, and *Ikegaya Y.
    A Low-Cost Method for Brain Slice Cultures.
    J. Pharmacol. Sci.,104:191-194, 2007.

  31. Tamura M, Koyama R, Ikegaya Y, Matsuki N, and *Yamada MK.
    K252a, an inhibitor of Trk, disturbs pathfinding of hippocampal mossy fibers.
    Neuroreport,17:481-486, 2006.

  32. Koyama R, Yamada MK, Fujisawa S, Katoh-Semba R, Matsuki N, and *Ikegaya Y.
    Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus.
    J. Neurosci., 24:7215-7224, 2004.

  33. Koyama R, Yamada MK, Nishiyama N, Matsuki N, and *Ikegaya Y.
    Developmental switch in axon guidance modes of hippocampal mossy fibers in vitro.
    Dev. Biol., 267:29-42, 2004.

  34. Kim JA, Koyama R, Yamada RX, Yamada MK, Nishiyama N, Matsuki N, and *Ikegaya Y.
    Environmental control of the survival and differentiation of dentate granule neurons.
    Cereb. Cortex, 14:1358-1364, 2004.

  35. Koyama R, Yamada MK, Nishiyama N, Matsuki N, and *Ikegaya Y.
    Group II metabotropic glutamate receptor activation is required for normal hippocampal mossy fibre development in the rat.
    J. Physiol. (Lond.), 539:157-162, 2002.

  36. *Ikegaya Y, Koyama R, Yamada MK, Nishiyama N, and Matsuki N.
    Rapid regrowth of hippocampal mossy fibres and preceding maturation of NMDA receptor-mediated neurotransmission.
    Eur. J. Neurosci., 15:1859-1862, 2002.

総説（*責任著者）

  1. Zhou Z, Ikegaya Y, and *Koyama R
    The astrocytic cAMP pathway in health and disease.
    Int J Mol Sci., 20:3, 2019.
  2. *Koyama R, and Ikegaya Y
    The molecular and cellular mechanisms of axon guidance in mossy fiber sprouting.
    Frontiers in Neurology, 9:382, 2018.
  3. Kasahara Y, Ikegaya Y, and *Koyama R
    Neonatal seizure models to study epileptogenesis.
    Frontiers in Pharmacology, 9:385, 2018.
  4. Hiragi T, Ikegaya Y, and *Koyama R
    Microglia after seizures and in epilepsy.
    Cells, 7(4). pii: E26, 2018.
  5. Luo C, Ikegaya Y, and *Koyama R
    Microglia and neurogenesis in the epileptic dentate gyrus.
    Neurogenesis, 3:e1235525, 2016.

  6. *Koyama R.
    Dentate circuitry as a model to study epileptogenesis.
    Biological and Pharmaceutical Bulletin, 39:1-6, 2016.

  7. *Koyama R, and Ikegaya Y.
    Microglia in the pathogenesis of autism spectrum disorders.
    Neuroscience Research, 100:1-5, 2015.

  8. *Koyama R.

    The use of organotypic slice cultures for the study of epileptogenesis.
    Neuropathology, 33:475-479, 2013.

  9. *Koyama R, and Matsuki N.
    Novel etiological and therapeutic strategies for neurodiseases: Mechanisms and consequences of febrile seizures: Lessons from animal models.
    J. Pharmacol. Sci., 113:14-22, 2010.

  10. *Koyama R, and Ikegaya Y.

    To BDNF or not to BDNF, that is the epileptic hippocampus.
    Neuroscientist, 11:282-287, 2005.

  11. Koyama R, and *Ikegaya Y.
    Mossy fiber sprouting as a potential therapeutic target for epilepsy.
    Curr. Neurovasc. Res., 1:3-10, 2004.

国内誌

総説

  1. 安藤めぐみ、池谷裕二、小山隆太
    自閉症におけるミクログリア依存的シナプス除去の不全とその回復
    実験医学、37(17):110-117, 2019.
  2. 星雄高、小山隆太
    脳疾患におけるTRPV4の関与
    医学のあゆみ、270(10):930-933, 2019.
  3. 安藤めぐみ、池谷裕二、小山隆太
    マイクログリアによるASD回路の再編
    児童青年精神医学とその近接領域、59:2-7, 2018.
  4. 平木俊光、池谷裕二、小山隆太
    てんかん脳におけるミクログリアの役割
    てんかん研究、36(3):678-682, 2019.
  5. 平木俊光、池谷裕二、小山隆太
    てんかん脳におけるマイクログリア動態とこれを標的にした創薬の可能性
    医薬品医療機器レギュラトリーサイエンス、49(9):617-626, 2018.
  6. 安藤めぐみ、池谷裕二、小山隆太
    マイクログリアによるASD回路の再編
    児童青年精神医学とその近接領域、59:2-7, 2018.
  7. 大柿安里、池谷裕二、小山隆太
    ショートレビュー、ミクログリアは記憶するか？
    実験医学、36:2222-2223, 2018.
  8. 笠原由佳、池谷裕二、小山隆太
    マウス熱性けいれんモデルの作製
    日本薬理学雑誌、150:263-267, 2017.
  9. 安藤めぐみ、池谷裕二、小山隆太
    ＡＳＤのモデル動物
    分子精神医学、17:41-48, 2017.

  10. 安藤めぐみ、池谷裕二、小山隆太

    自閉スペクトラム症とてんかん
    日本薬理学雑誌、    146:263-267, 2016.

  11. 周至文、羅聡、小山隆太
    胎生期および小児期におけるストレスと将来の精神神経疾患
    日本薬理学雑誌、146:263-267, 2015.

  12. 小山隆太

    抗てんかん薬の現在とこれから
    ファルマシア、    51:947-951, 2015.

  13. 周至文、小山隆太

    光活性化アデニル酸シクラーゼ：神経生物学の発展につがなる新たなツール
    日本薬理学雑誌、    146:119, 2015
  14. 小山隆太
    熱性けいれんの前方視的研究「FEBSTAT STUDY」への期待
    日本薬理学雑誌、    146:66, 2015.

  15. 小山隆太

    自閉スペクトラム症とマイクログリア
    細胞工学、34:472-475, 2015.

  16. 小山隆太

    てんかん脳における興奮性GABAシグナリングの役割
    生化学、    86:803-306, 2014.

  17. 小山隆太

    てんかん脳における異所性神経回路の形成メカニズムの解明
    薬学雑誌、    134:1171-1177, 2014.

  18. 小山隆太

    海馬の機能
    てんかんの総合学術誌『    Epilepsy』、16, 2014.

  19. 小山隆太、泉安彦

    若手薬理学者による脳疾患への挑戦ー分子から個体レベルに至る病態解明と創薬を目指してー
    薬学雑誌、    131:1-2, 2011.

  20. 市川淳也、松木則夫、小山隆太

    発達期の神経回路形成に与える熱性けいれんの影響－モデル動物の利用による細胞・分子レベルでの検証－
    日本薬理学雑誌、    136:219-224, 2010. 

その他

  1. 安藤めぐみ、小山隆太
    自閉症様マウスへの運動の効果とヒトへの応用の可能性
    発達教育、2019年11月号,2019.

  2. 小山隆太

    私の研究紹介、脳疾患の分子病態におけるニューロン-グリア相関の研究
    分子精神医学、    16:56-57, 2016.

  3. 小山隆太

    リレーエッセイ、てんかん発症メカニズムの解明を目指す研鑽の日々
    日本薬理学雑誌、    135:265, 2010.

  4. 小山隆太

    A Report on the 17th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN)  （「ISDN 第17回集会」に参加して）
    神経科学ニュース、    4:5-8, 2008.

  5. 小山隆太

    第81回年会開催記念 市民公開講座 「知っておきたいくすりの知識―知っているようで知らない薬のこと―」を開催して
    日本薬理学雑誌、    131:487, 2008.

  6. 小山隆太

    トラベルアワード受賞者　北米神経科学大会参加報告　「乳幼児期における歯状回顆粒細胞の移動機構の解明」
    神経科学ニュース、    1:17-18, 2008.

  7. 小山隆太

    研究集会レポート　「NIPS-JST 国際ワークショップ「-From photon to mind- Advanced Nonlinear Imaging and Fluorescence-based Biosensors」から」
    神経科学ニュース、    3:20-22, 2008.