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    Sisunknown
    Short for the word “sister” but also just an answer to any question ever.
    Susan: “how was your weekend?”
    Janet: “sis...”
    Susan: “omg sis what’s the tea sis—spill!”
    Janet: “sis!”
    Susan “sis”
    —and so on and so forth until Antichrist comes and the world is over
    #sis#sister#antichrist#help me
    by Theworldisflat.edu August 03, 2018
    22622
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    sisunknown
    Short for sister, commonly used as a term of endearment to friends in urban new york/jersey areas
    hey, sis, whats up
    #bro#homie#friend#bffl
    by Caroline Might Fine November 14, 2016
    496
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    3
    sisunknown
    Not meaning “sister”. Commonly used to refer to a close friend or bestfriend.
    “what’s up, sis”
    by kaitlyn pender January 24, 2019
    274
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    sisunknown
    the abbreviation of "sister";
    a genderless term much like "bro" or "dude"

    people can also say it like "sister" but that doesn't change the definition

    like when you say "brother" instead of "bro"
    -"How do you feel about celebrity drama?"
    -"It's the tea, sis."

    -"Hey sisters!" -James Charles

    -"How u doing?"
    -"I'm so fucking depressed, sister"
    #sis#sister
    by Bakuhoe Katsubitch January 09, 2019
    193
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    5
    sisunknown
    1) Short for sister
    2) In the song Fuck the Pain Away by Peaches, SIS seems to stand for Stay In School...
    My sis went to the movies with a scumball.

    "Stay in school... Cause it's the best..."
    by wxynot July 12, 2005
    399143
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    6
    SISunknown
    Abbreviation for: "Sisters, In, Spirit". Your Best Friend or Bae. Usually used to refer to someone really close to you, someone you spend a lot of time with, like your sister.
    Girl: OMG, squad on fleek!
    Girl 2: yas, we look #Fabulous
    Girl: Yas Sis Yas!
    #bae#boo#bff#fam#bestie
    by ChocolateWafflez April 15, 2015
    8425
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    7
    sisunknown
    Slang for sister
    Me and my sis went to the movies.
    by Thunderchild March 25, 2003
    19570
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