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i, for one, don't see it as a singular tipping point upon which the cancer came into being, but rather a progressive influx of various social groups at various points since the inception of the internet.
the late 2000s brought autistic minecraft kids, who have since "matured" into redditfags. the early 2010s brought SJWs. instathots and facebook boomers are widespread and are considered mainstream. cancer is everywhere.
as for imageboards, the final nail in the coffin for me was variations of Pepe and Wojak being regarded as the highest form of OC. that, and having spent over a decade of my life on imageboards i can't expect them to still bring me the same amount of joy as they did in 2008.