For more information and free PDF
〇Natural history of thyroid cancers. Endocr J 64:237-244, 2017
https://www.jstage.jst.go.jp/article/endocrj/64/3/64_EJ17-0026/_article
Our group first presented gene expression profile in thyroid carcinoma and proposed a novel theory of carcinogenesis, fetal cell carcinogenesis in 2000. Now many researchers regard this theory as a pioneer in fetal cell research in the next generation. We establised Aspiration Biopsy Nucleic Acid Dianosis (ABND) using TFF3-based analysis and FACS-mQ in which stem cells or cancer initiating cells are analyzed efficiently and easily.
Recent evidences that support fetal cell carcinogenesis
１．Korean's thyroid cancer "Epidemic"
Preventive surgical resection of small carcinomas did not decrease cancer mortality, which suggested that small carcinomas do not progress to cause cancer death.
２．Fukushima Health Management Survey
Thyroid cancer was found in 1/2700 children, which suggested that the prevalence of juvenile thyroid cancer is high.
３．Observation trials of papillary thyroid microcarcinoma (PTM)
1) It takes decades for PMCs to grow. 2 ) PMCs in younger patients grow faster. 3) No patient died from thyroid cancer during the trails. These data suggested that initiation of thyroid cancer is during the infantile period, and PMCs do not progress to cause cancer death.
４．Whole exome sequencing using samples in which both differentiated and anaplastic thyroid carcinomas co-exist
Two carcinomas shared only a limited number of genetic alternation. There were many mutation found only in “differentiated” carcinomas. These results suggested these two may share a common origin, but developed independently.
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For more information and free PDF
〇Natural history of thyroid cancers. Endocr J 64:237-244, 2017
https://www.jstage.jst.go.jp/article/endocrj/64/3/64_EJ17-0026/_article
Overdiagnosis of Juvenile Thyroid Cancer
Early diagnosis of self-limiting cancner results in overdiagnosis
Fetal cell carcinogenesis theory suggested the existence of self-limiting cancer, which acts as cancer showing the ability of invasion and metastasis, but shows limitation in proliferation. Early diagnosis of such cancer results in overdiagnosis. Recent clinical data showed that juvenile thyroid cancer acts like self-limiting caner. As a member of the Oversight Committee of the Fukushima Management Survey and the Task Force for Thyroid Examination in Fukushima, Japan (2017-2019), Dr. Takano advocated the risk of thyroid US screening for children which is now ongoing in Fukushima.
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For more information and free PDF
1. Overdiagnosis of thyroid cancer in Fukushima. J Soc Risk Analysis, Japan 28:67-76, 2019
https://doi.org/10.11447/sraj.28.67 (In Japanese、abstract in English) Free PDF
2. Overdiagnosis of thyroid cancer: The children in Fukushima are in a danger.
Arch Pathol Lab Med 143:660-661, 2019
ttakano@labo.med.osaka-u.ac.jp [Past presentations in international conferences]
1) Toru Takano: Preoperative molecular diagnosis of thyroid nodule: How does it help? (Lecture)
The 3rd Asian Masterclass of Thyroid Cancer, Taipei, Taiwan, 2014
2) Toru Takano: Fetal cell carcinogenesis: present status and future prospect (Symposium)
The 21st International Symposium on Molecular Thyroidology, Osaka Japan, 2014
3) Toru Takano: Molecular-based classification of thyroid tumor for the use of pre-and post operative diagnoses (Lecture)
The 4th Asian master class of Thyroid Cancer, Hong Kong, China, 2015
4) Toru Takano: Fetal cell carcinogenesis of the thyroid (Symposium)
2015Annual Autumn Meeting of Korean Endocrine Society, Busan, Korea, 2015