は,怪しさ満載の歴史だった.
MBD2がDNAの脱メチル化酵素だとかいうのもあったし,MBD4が脱メチル化酵素だとかあったけれども,2009年のTETで落ち着いているけれども,それでもいろいろ疑問は残る.
Kmがかなり低い.1 μMってのは,CXXCなみのもの.
制限酵素なんかは1桁nMなので,1000倍.
あとKcatも in vitroだからというのがあっても非常に遅い.
(遅い酵素は結構できることが限られてしまう...
弱酸性で活性が高い.Ferrusを使うからとは言え,lower pHはDNAにとってあまり良くない.切れるから.なんとか刺激細胞とか笑っちゃうわ...
低pHではガン化が起こりにくいというのもおかしな話.切られるとNHEJが起こるわけで全く脈略のない子供騙しの話.かつ,化学を得意とされていたとか...
どっかのレビューにも書いたと思うのだけれども,
炭素原子についているメチル化と窒素原子についているメチル化とでは反応性が違って,ハイドロキシ化させると自然と窒素の方では脱メチル化が行われてしまう.
ヒストンライシンの脱メチル化酵素なんかはこっち.
もともとLSD1の件があって,,,というもの.
これらは全てDSBHをもつので,構造的にDSBHを持つということはオッズが低いのであまり面白くない.基質をどのように認識するか?の一択が構造解析に求められていた.ストーリー,リバトルの内容まで綺麗に中国のグループにぱくられた.彼らは僕らの原稿を不正に入手して論文を出した.かつ内部告発メールまで受け取った.ほんと呆れる...
DNAメチル化は1975年に発見されて,メチル化酵素が1992年ぐらいに発見されていたのだけれども,脱メチル化酵素は見つかっていなかったという歴史的な背景があった.
MBD4自体は1999年のNatureに発表されて,メチル化結合ドメインと,GT mismatch glycosylaseドメインを持つことが報告された.
MBD4が脱メチル化酵素と言われていたのはまさしくグライコシレースドメインを持つためで,ニワトリのMBD4で5mCの活性があると報告されたのが2000年のNAR.
不思議なことにTDGには5mCを切断するなんて噂すら聞いていない.し,加藤グループもそれに乗ってこなかった.
おそらく,MBD4の脱メチル化活性はプローブDNAの合成過程のimpurityを検出して騒いでいたのだろう.他にも1本,不思議なことに今となっては追試できるわけがないはずのものが,追試され再現されていた.
が,2002年のScienceでノックアウトマウスでは若干C->Tのmutationが増えているだけというあまり期待の薄い結果でそれで終わりかのように思われた.
ちなみにTDGはembryonic lethal
それでも,εCを切断するとか,もう詐欺的なもの?おそらくこれもimpurityを検出したりするものまで.
![Untitled](data:image/png;base64,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)
バンドらしきものが見えるけれども,それはほんとのほんとに,εC由来???ということに答えられないわけで,詐欺的だわな.
APE(AP endonuclease)を加えてなので,こんなのがイプシロンCに活性があるとは,平常心では言えない.よっぽど血迷っていたのか?という感じかつ,それが一人歩きしている.
レビューを書くときに論文を読んだか?そう書いてあるから,そう書いているだけ???というレベルの低い...一度書かれたことを訂正するのは相当難しい.あとは推して知るべしということになる...
Turn-overしない(つまりみかけのKoffが遅すぎるので,turn-overしない酵素にKcatなんて概念はない.)これらのDNA修復酵素にAPEを加えると,APEがAP siteに強く結合するので,glycosylase domainが乖離することで,見かけ上,turn-overする.
さらにcatalytic residueとしてAspを使っているので,lower pHで活性が下がるのに,彼らは下がっていなかったり,60℃でもまだまだ活性があるって本当かよ?ってな感じ...
Superdex 200 PC 3.2/30を使っているって,どんなけ微量???ってな感じ.
AID/MBD4/Gaddの合わせ技であったり(Cell)まぁ,なんともどこまで信じたらいいのやら...
時期的にはTETの論文が6月ごろScienceに出て,という背景.
そして2009年にNatureに,加藤グループからリン酸化すると5mCの活性が上がるという捏造論文が出たけれども,あのメガコリゲはなんだったんだ?という感じ.
ご丁寧にTDGは5mCを塩基除去しないというデータまで...これはレビューアーが要求したものだろう.この実験の意味は非常に大きい.
これを機に,追試ができないという問題がいろいろ出ていた.し,僕も追試できないことを論文に出している2012a NAR
2012年に(実際にわかったのは2011年の10月),僕が構造をみて,メチル化を絶対に塩基除去しないというメカニズムを明らかにした.εCはやっていないけれども,あれも無理.
以前総括したと思うのだけれども,
これらの全てのbiochemistryがグダグダな点.
これは2000年の時点でturn overしない酵素.ということがわかっていた.
彼らは酵素活性速度も計算してこなかった.
最初から活性速度を調べていたらそんなことはならなかっただろう.
non-turn over enzymeの反応は酵素の量を基質の10倍以上加えることで,ほぼ完全に基質を反応させること.
1:1で混ぜれば,半分ぐらいは反応しない.
フリーの酵素の濃度が低くなるので,基質に結合できなくなるので.Kdは20 nMぐらいだったけれども.
なので[E]>>>[S]の状態でタイムコースを取ることが必要で,ある1点の時間のポイントで活性がある,ないというのを判断するのは間違いの元になる.
biochemistが乗り出して,この辺をきっちり抑えられていれば,それで終わりだったわけだわ.
なぜ,メチル化Cを塩基除去できないのか?という質問には答えられないけれども.その答えはmutantをつかった基質複合体の構造解析を見れば一瞬で答えが出た.
5%のimpurityがあったとしても,最初の2000年のNARで,コントロールとなるG:T, G:Uで90%以上切れるという結果を示せず,ちょろっとあればそれで活性とみなす,biochemistがやらない方式でOKとするから問題になるわけ.
最初の2000年のNARの論文で何が起こっていたはわからないけれども,
表面的なフェのタイプを追っているだけではダメで,因果関係をbiochemistryで明らかにしていくというのが必要なはずだけれども,
こういったbiochemistryは概して,評価が低い.
はやりの技術じゃないし.
本当に低い.
それはopen questionでしょ?ということになる.
アプローチの仕方も,なにをするわけでもないtraditionalなbiochemと結晶構造解析でしょ?
ということになるらしい.
とはいうもののほぼ完璧に15年間のアーギューを綺麗に答えることが出来た.
細かいことを言えば,そこに至る技術的な問題を克服する必要もあったわけで,2003年(jbc)には出来なかったことをやっている.
こういう技術はon-demandなので,問題点が理解できないとってことになる.
(ちなみにこのプロジェクトは2011年の8月から初めて12月までの4ヶ月での仕事で,いろいろあったのでpublishまでに時間がかかってしまった.)
個人的には面白いと思って色々やっているわけで,因果関係を明らかにしないまま,表面だけ追っていれば痛い目にあうよということ.
ケン先生もヴィクター先生もbiochemistとしていろいろ評価してくれている.
ま,それぐらいで十分と言えばそうかもな.
基本biochemistryは間違っている度はかなり低い.
CTCFがnucleosomeに結合するとかいうのもノンスペだろうし,ヌクレオソームがなんとかのenzymeだというのも何か(金属?)のコンタミだろう.
こういうのはCellによく出る.natureには出ない.が,加藤茂明氏のあの論文もnatureだったわけだったわけだし.
そのへんがくだらないってところになるし,そういうので賞を決めるのもな...ってことになる.
個人的な印象ではCellのエディターはあまり倫理観が高くないように思わせる論文が結構ある.
MBD2がDNAの脱メチル化酵素だとかいうのもあったし,MBD4が脱メチル化酵素だとかあったけれども,2009年のTETで落ち着いているけれども,それでもいろいろ疑問は残る.
Kmがかなり低い.1 μMってのは,CXXCなみのもの.
制限酵素なんかは1桁nMなので,1000倍.
あとKcatも in vitroだからというのがあっても非常に遅い.
(遅い酵素は結構できることが限られてしまう...
弱酸性で活性が高い.Ferrusを使うからとは言え,lower pHはDNAにとってあまり良くない.切れるから.なんとか刺激細胞とか笑っちゃうわ...
低pHではガン化が起こりにくいというのもおかしな話.切られるとNHEJが起こるわけで全く脈略のない子供騙しの話.かつ,化学を得意とされていたとか...
どっかのレビューにも書いたと思うのだけれども,
炭素原子についているメチル化と窒素原子についているメチル化とでは反応性が違って,ハイドロキシ化させると自然と窒素の方では脱メチル化が行われてしまう.
ヒストンライシンの脱メチル化酵素なんかはこっち.
もともとLSD1の件があって,,,というもの.
これらは全てDSBHをもつので,構造的にDSBHを持つということはオッズが低いのであまり面白くない.基質をどのように認識するか?の一択が構造解析に求められていた.ストーリー,リバトルの内容まで綺麗に中国のグループにぱくられた.彼らは僕らの原稿を不正に入手して論文を出した.かつ内部告発メールまで受け取った.ほんと呆れる...
DNAメチル化は1975年に発見されて,メチル化酵素が1992年ぐらいに発見されていたのだけれども,脱メチル化酵素は見つかっていなかったという歴史的な背景があった.
MBD4自体は1999年のNatureに発表されて,メチル化結合ドメインと,GT mismatch glycosylaseドメインを持つことが報告された.
MBD4が脱メチル化酵素と言われていたのはまさしくグライコシレースドメインを持つためで,ニワトリのMBD4で5mCの活性があると報告されたのが2000年のNAR.
不思議なことにTDGには5mCを切断するなんて噂すら聞いていない.し,加藤グループもそれに乗ってこなかった.
おそらく,MBD4の脱メチル化活性はプローブDNAの合成過程のimpurityを検出して騒いでいたのだろう.他にも1本,不思議なことに今となっては追試できるわけがないはずのものが,追試され再現されていた.
が,2002年のScienceでノックアウトマウスでは若干C->Tのmutationが増えているだけというあまり期待の薄い結果でそれで終わりかのように思われた.
ちなみにTDGはembryonic lethal
それでも,εCを切断するとか,もう詐欺的なもの?おそらくこれもimpurityを検出したりするものまで.
バンドらしきものが見えるけれども,それはほんとのほんとに,εC由来???ということに答えられないわけで,詐欺的だわな.
APE(AP endonuclease)を加えてなので,こんなのがイプシロンCに活性があるとは,平常心では言えない.よっぽど血迷っていたのか?という感じかつ,それが一人歩きしている.
レビューを書くときに論文を読んだか?そう書いてあるから,そう書いているだけ???というレベルの低い...一度書かれたことを訂正するのは相当難しい.あとは推して知るべしということになる...
Turn-overしない(つまりみかけのKoffが遅すぎるので,turn-overしない酵素にKcatなんて概念はない.)これらのDNA修復酵素にAPEを加えると,APEがAP siteに強く結合するので,glycosylase domainが乖離することで,見かけ上,turn-overする.
さらにcatalytic residueとしてAspを使っているので,lower pHで活性が下がるのに,彼らは下がっていなかったり,60℃でもまだまだ活性があるって本当かよ?ってな感じ...
Superdex 200 PC 3.2/30を使っているって,どんなけ微量???ってな感じ.
AID/MBD4/Gaddの合わせ技であったり(Cell)まぁ,なんともどこまで信じたらいいのやら...
時期的にはTETの論文が6月ごろScienceに出て,という背景.
そして2009年にNatureに,加藤グループからリン酸化すると5mCの活性が上がるという捏造論文が出たけれども,あのメガコリゲはなんだったんだ?という感じ.
ご丁寧にTDGは5mCを塩基除去しないというデータまで...これはレビューアーが要求したものだろう.この実験の意味は非常に大きい.
これを機に,追試ができないという問題がいろいろ出ていた.し,僕も追試できないことを論文に出している2012a NAR
2012年に(実際にわかったのは2011年の10月),僕が構造をみて,メチル化を絶対に塩基除去しないというメカニズムを明らかにした.εCはやっていないけれども,あれも無理.
以前総括したと思うのだけれども,
これらの全てのbiochemistryがグダグダな点.
これは2000年の時点でturn overしない酵素.ということがわかっていた.
彼らは酵素活性速度も計算してこなかった.
最初から活性速度を調べていたらそんなことはならなかっただろう.
non-turn over enzymeの反応は酵素の量を基質の10倍以上加えることで,ほぼ完全に基質を反応させること.
1:1で混ぜれば,半分ぐらいは反応しない.
フリーの酵素の濃度が低くなるので,基質に結合できなくなるので.Kdは20 nMぐらいだったけれども.
なので[E]>>>[S]の状態でタイムコースを取ることが必要で,ある1点の時間のポイントで活性がある,ないというのを判断するのは間違いの元になる.
biochemistが乗り出して,この辺をきっちり抑えられていれば,それで終わりだったわけだわ.
なぜ,メチル化Cを塩基除去できないのか?という質問には答えられないけれども.その答えはmutantをつかった基質複合体の構造解析を見れば一瞬で答えが出た.
5%のimpurityがあったとしても,最初の2000年のNARで,コントロールとなるG:T, G:Uで90%以上切れるという結果を示せず,ちょろっとあればそれで活性とみなす,biochemistがやらない方式でOKとするから問題になるわけ.
最初の2000年のNARの論文で何が起こっていたはわからないけれども,
表面的なフェのタイプを追っているだけではダメで,因果関係をbiochemistryで明らかにしていくというのが必要なはずだけれども,
こういったbiochemistryは概して,評価が低い.
はやりの技術じゃないし.
本当に低い.
それはopen questionでしょ?ということになる.
アプローチの仕方も,なにをするわけでもないtraditionalなbiochemと結晶構造解析でしょ?
ということになるらしい.
とはいうもののほぼ完璧に15年間のアーギューを綺麗に答えることが出来た.
細かいことを言えば,そこに至る技術的な問題を克服する必要もあったわけで,2003年(jbc)には出来なかったことをやっている.
こういう技術はon-demandなので,問題点が理解できないとってことになる.
(ちなみにこのプロジェクトは2011年の8月から初めて12月までの4ヶ月での仕事で,いろいろあったのでpublishまでに時間がかかってしまった.)
個人的には面白いと思って色々やっているわけで,因果関係を明らかにしないまま,表面だけ追っていれば痛い目にあうよということ.
ケン先生もヴィクター先生もbiochemistとしていろいろ評価してくれている.
ま,それぐらいで十分と言えばそうかもな.
基本biochemistryは間違っている度はかなり低い.
CTCFがnucleosomeに結合するとかいうのもノンスペだろうし,ヌクレオソームがなんとかのenzymeだというのも何か(金属?)のコンタミだろう.
こういうのはCellによく出る.natureには出ない.が,加藤茂明氏のあの論文もnatureだったわけだったわけだし.
そのへんがくだらないってところになるし,そういうので賞を決めるのもな...ってことになる.
個人的な印象ではCellのエディターはあまり倫理観が高くないように思わせる論文が結構ある.
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