NMReady-60

‘The spectra were analyzed according to first order’. Does this sound familiar to you? Most of the supporting information documents out there contain this sentence. You find yourself asking ‘why does nobody care about second order effects?’, then check out this high-order blog entry on the topic.

The ability to monitor and follow a chemical reaction allows chemists to study and understand the underlying factors that govern the outcome of a reaction. NMR spectroscopy is well suited for this application due to the quantitative nature of the technique as well as its superior structural elucidation capabilities. With the rise of benchtop NMR spectroscopy leading to greater access to this technique, we have previously demonstrated the use of our instrument for such purposes. In this example, adapted from a J. Chem. Ed. article recently published by Thananatthanachon and Lecklider,1 the nickel catalyzed Suzuki cross-coupling reaction of 1-bromo-4-(trifluoromethyl)benzene (1) and phenylboronic acid (2) to form 4-(trifluoromethyl)biphenyl (3) was monitored by 19F NMR spectroscopy with the NMReady-60PRO instrument.