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DRUG AND CHEMICAL INDUCED PARKINSON’S DISEASEThere are countless references in medical textbooks and papers to the many dopamine antagonist drugs and chemicals known to cause Parkinson’s disease and this short paper is just a short summary to add to my website until I have time to write a longer more detailed one. References to medical textbooks and papers are given in the text instead of being listed at the end as is usual with most medical papers. The British National Formulary written by the B.M.A. and The Royal Pharmaceutical Society of Great Britain and issued 6 monthly in March and September for the medical profession in the U.K. to use when prescribing, notes that the phenothiazine anti-psychotic drugs can cause Parkinson’s disease but that on onset of the symptoms of Parkinson’s if the drug is withdrawn the symptoms usually subside. Rachel Carson, the U.S. biologist in her internationally famous book “Silent Spring” 1962, notes on page 182 in the chapter “through a Narrow Window” that phenothiazines are used as pesticides and are like D.D.T., lindane and many other now banned pesticides uncouplers of ATP (adenosine triphosphate) causing effects on locking up the energy in the mitochondria and other serious health effects. Oxford University textbook on “Adverse Drug Reactions” edited by D.M. Davies gives a list of 15 commonly prescribed drugs which are documented to cause Parkinson’s disease, eight of which are the neuroleptics the phenothiazines. The Pharmaceutical Journal Vo. 251 dated 2nd October 1993 on pages 448 and 454 carried reports on the drugs and herbicides documented to cause Parkinson’s disease. From time to time the media has some reports of drugs and chemicals causing Parkinson’s disease and one I have to hand is from The Woman magazine dated 119th February, 2001 which states of Parkinson’s “What are the causes” and then says that there are several possible causes including “certain types of poisoning and various drugs”. These reports seem to go generally unnoticed by most of the media and the public could be forgiven if they thought there were no known causes as most T.V. and media reports and the Parkinson’s Society always say that the causes are unknown. A very technical book I have “Design of Enzyme Inhibitors as Drugs” by Oxford University Press dated 1989 notes of Parkinson’s disease that there are exposures to other agents, which can act as a catalysts making the effects of drugs and chemicals known to cause the condition irreversible. This includes some chemicals and ultra-violet light. David F. Horrobin, M.A., D.Phil., B.M.,B.Ch. (reader of physiology The Medical school, University of Newcastle-upon-Tyne, 1972) in his book “Prolactin: Physiology and Clinical Significance” has a chapter 29 on page 153 on “Natural and Drug Induced Parkinsonism” This gives some of the then known pathways in which drugs and chemicals which are dopamine antagonists cause Parkinson’s disease. On 13th February, 1993 The Observer newspaper carried a long article on Page 9 with the title ‘Mystery of harmless secrets the state dare not tell’. In this list is what the Observer newspaper thought was a stupid and harmless secret act put in place for 75 years by the UK Government in World War 2, so it is still in force today...! This Official Secrets Act is on the effects of ultra violet street lighting, which was not adopted in WW2. I wrote to the Observer pointing out that this Secrets Act was perhaps not as harmless and stupid as they said it was if you looked at the very harmful effects of ultra-violet street lighting and any on the countless 1000’s of people exposed to the herbicides and drugs documented to cause them!
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