Most of us work for a company with multiple AWS accounts. Perhaps there is one for Production and another one for everything else. Perhaps more. From a security perspective, this account-level isolation is great.
When it comes to running a reliable system, we've been trained to utilize services across multiple regions. An RDS master in N. Virginia and a read-replica in Oregon, for example.
We all know managing this type of infrastructure requires automation, so there's a little CloudFormation here, some custom scripts there, maybe even a little Terraform if you're into that kinda thing. It's ...