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Psychiatric Genomics: An Update and an Agenda

View ORCID ProfilePatrick F Sullivan, View ORCID ProfileArpana Agrawal, View ORCID ProfileCynthia Bulik, View ORCID ProfileOle A. Andreassen, View ORCID ProfileAnders Borglum, View ORCID ProfileGerome Breen, View ORCID ProfileSven Cichon, View ORCID ProfileHoward Edenberg, Stephen V Faraone, View ORCID ProfileJoel Gelernter, View ORCID ProfileCarol A Mathews, Caroline M Nievergelt, View ORCID ProfileJordan Smoller, View ORCID ProfileMichael O'Donovan
doi: https://doi.org/10.1101/115600
Patrick F Sullivan
University of North Carolina;
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Arpana Agrawal
WUSTL;
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Cynthia Bulik
UNC;
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Ole A. Andreassen
U Oslo;
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Anders Borglum
Aarhus University;
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Gerome Breen
Kings College London;
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Sven Cichon
University of Basel;
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Howard Edenberg
Indiana University;
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Stephen V Faraone
SUNY;
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Joel Gelernter
Yale University;
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Carol A Mathews
University of Florida;
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Caroline M Nievergelt
UCSD;
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Jordan Smoller
Harvard University;
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Michael O'Donovan
Cardiff University
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Abstract

The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. In the past decade, this global effort has delivered a rapidly increasing flow of new knowledge about the fundamental basis of common psychiatric disorders, particularly given its dedication to rapid progress and open science. The PGC has recently commenced a program of research designed to deliver “actionable” findings - genomic results that (a) reveal the fundamental biology, (b) inform clinical practice, and (c) deliver new therapeutic targets. This is the central idea of the PGC: to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. The emerging findings suggest that we are entering into a phase of accelerated translation of genetic discoveries to impact psychiatric practice within a precision medicine framework.

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  • Posted March 10, 2017.

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Psychiatric Genomics: An Update and an Agenda
Patrick F Sullivan, Arpana Agrawal, Cynthia Bulik, Ole A. Andreassen, Anders Borglum, Gerome Breen, Sven Cichon, Howard Edenberg, Stephen V Faraone, Joel Gelernter, Carol A Mathews, Caroline M Nievergelt, Jordan Smoller, Michael O'Donovan
bioRxiv 115600; doi: https://doi.org/10.1101/115600
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Psychiatric Genomics: An Update and an Agenda
Patrick F Sullivan, Arpana Agrawal, Cynthia Bulik, Ole A. Andreassen, Anders Borglum, Gerome Breen, Sven Cichon, Howard Edenberg, Stephen V Faraone, Joel Gelernter, Carol A Mathews, Caroline M Nievergelt, Jordan Smoller, Michael O'Donovan
bioRxiv 115600; doi: https://doi.org/10.1101/115600

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