Safe and Ethical Use: Technologies that intervene with human physiology for curing disease and repairing injury have accelerated to a point in which they also can increase human performance outside the realms of what is considered to be “normal” for humans. These technologies are referred to as emerging and speculative and include nanotechnology, nanomedicine, biotechnology, genetic engineering, stem cell cloning, and transgenesis, for example. Other technologies that could extend and expand human capabilities outside physiology include artificial intelligence, artificial general intelligence, robotics, and brain-computer integration, which form the domain of bionics, uploading, and could be used for developing whole body prosthetics. Because these technologies, and their respective sciences, would take the human beyond the normal state of existence, society, including bioethicists and others who advocate the safe use of technology, have shown concern and uncertainties about the downside of these technologies and possible problematic and dangerous outcomes for our species.