Genoset
A genoset refers to a defined set of genotypes; we have coined the term to represent the combination of alleles at 2 or more loci, especially when they are not contiguous along a chromosome. Typically, these are then related to a medical (or ancestral) consequence that arises only when a particular combination of SNPs is inherited.
Promethease understands this criteria syntax.
More information about genosets can be found in the related SNPedia blog post. Note that genosets themselves are boolean, not quantitative; each genoset is either true (present) or false (absent) in an individual, based on the genoset's criteria, in the same way that a genotype (or allele) is either present or absent. Note that if a DNA microarray platform lacks a given SNP, genosets that require it (that SNP) will not return a result during a Promethease evaluation.
Most Significant
| Repute | Magnitude | Summary | Modification date "Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki. | |
|---|---|---|---|---|
| Gs149 | 10 | testing for orientation issues | 17 August 2015 21:57:17 | |
| Gs303 | 7 | WeGene quality control issues. | 8 June 2016 05:40:37 | |
| Gs300 | 7 | Data Quality issue. Your data provider is reporting heterozygosity on the Y chromosome. | 23 October 2016 09:50:25 | |
| Gs228 | Bad | 6 | sickle cell affected | 25 October 2012 02:21:38 |
| Gs267 | 6 | APOE1/APOE1 | 5 November 2016 18:42:06 | |
| Gs216 | Bad | 6 | 2 copies of the APOE-ε4 allele | 25 January 2017 16:02:20 |
| Gs121 | Bad | 5 | DR3/4-DQ8 individual at high risk for type-1 diabetes | 21 October 2011 06:04:16 |
| Gs261 | 5 | Did you mix multiple people together? | 13 March 2017 17:50:25 | |
| Gs266 | 5 | Data Quality Warning | 21 September 2016 10:51:44 | |
| Gs305 | Bad | 5 | Likely carrier of one PiS and one PiZ Alpha-1 Antitrypsin (SERPINA1) alleles; A1AT deficiency | 29 April 2017 17:17:29 |
| …その他の結果 | ||||
Most Recently Active
| Repute | Magnitude | Summary | Modification date "Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki. | |
|---|---|---|---|---|
| Gs305 | Bad | 5 | Likely carrier of one PiS and one PiZ Alpha-1 Antitrypsin (SERPINA1) alleles; A1AT deficiency | 29 April 2017 17:17:29 |
| Gs232 | 1.7 | possible low pain sensitivity; LPS/LPS | 15 April 2017 02:33:34 | |
| Gs233 | 1.7 | normal pain sensitivity; APS/APS, LPS/APS, and APS/HPS diplotypes | 15 April 2017 02:33:03 | |
| Gs234 | Bad | 1.7 | possible high pain sensitivity; HPS/HPS or HPS/APS | 15 April 2017 02:29:50 |
| Gs278 | Good | 1.5 | Better episodic memory in older age | 31 March 2017 11:33:13 |
| Gs261 | 5 | Did you mix multiple people together? | 13 March 2017 17:50:25 | |
| Gs304 | Bad | Familial hypercholesterolemia is a genetic disorder characterized by very high levels of low-density lipoprotein in the blood. Individuals with FH are less responsive to cholesterol control methods which are usually effective for people without FH (such as dietary modification and statin). | 1 March 2017 15:56:09 | |
| Gs216 | Bad | 6 | 2 copies of the APOE-ε4 allele | 25 January 2017 16:02:20 |
| Gs193 | 3.1 | effects due to MTHFR polymorphisms affecting homocysteine? | 5 January 2017 17:22:56 | |
| Gs267 | 6 | APOE1/APOE1 | 5 November 2016 18:42:06 | |
| …その他の結果 | ||||
You can create a new genoset by clicking that link and filling in the form. But you'll still need to populate the criteria syntax.
